Zhuohua Zhang

[A simple and convenient method for construction of gene site-directed mutagenesis].

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.

Aggregate formation and synaptic abnormality induced by DSCR1.

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.

Differential distribution of KChIPs mRNAs in adult mouse brain.

beta-Catenin activates the growth factor endothelin-1 in colon cancer cells.

Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells.

Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.

Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules.

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons.

Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

KChIP1: a potential modulator to GABAergic system.

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.

Genetic screening for mutations in the Nrdp1 gene in Parkinson disease patients in a Chinese population.

Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety.

Trafficking abnormality and ER stress underlie functional deficiency of hearing impairment-associated connexin-31 mutants.

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

Critical role of PINK1 in regulating Parkin protein levels in vivo.

Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition.

Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein.