Matthias Heinemann

New insights in the spatially resolved dynamic pH measurement in macroscopic large absorbent particles by confocal laser scanning microscopy.

Optimization of enzymatic gas-phase reactions by increasing the long-term stability of the catalyst.

Method for quantitative determination of spatial polymer distribution in alginate beads using Raman spectroscopy.

In silico genome-scale reconstruction and validation of the Staphylococcus aureus metabolic network.

Optimization of adsorptive immobilization of alcohol dehydrogenases.

Suitability of teicoplanin-aglycone bonded stationary phase for simulated moving bed enantioseparation of racemic amino acids employing composition-constrained eluents.

Integrated operation of continuous chromatography and biotransformations for the generic high yield production of fine chemicals.

Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data.

Characterization of the AlkS/P(alkB)-expression system as an efficient tool for the production of recombinant proteins in Escherichia coli fed-batch fermentations.

Synthetic biology--putting engineering into biology.

Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotype.

Systematic assignment of thermodynamic constraints in metabolic network models.

Genetics. Getting closer to the whole picture.

Living with an imperfect cell wall: compensation of femAB inactivation in Staphylococcus aureus.

anNET: a tool for network-embedded thermodynamic analysis of quantitative metabolome data.

Mass spectrometric method for analyzing metabolites in yeast with single cell sensitivity.

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.

A divide-and-conquer approach to analyze underdetermined biochemical models.

Physiology of mycobacteria.

Nutritional systems biology modeling: from molecular mechanisms to physiology.

Exploiting cell-free systems: Implementation and debugging of a system of biotransformations.

Differential glucose repression in common yeast strains in response to HXK2 deletion.

Bacterial adaptation through distributed sensing of metabolic fluxes.

Systems biology of microbial metabolism.

Single cell metabolomics.

Thermodynamic calculations for biochemical transport and reaction processes in metabolic networks.

From good old biochemical analyses to high-throughput omics measurements and back.

Comprehensive quantitative analysis of central carbon and amino-acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics.

Optimization of a blueprint for in vitro glycolysis by metabolic real-time analysis.

The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1.

Condition-dependent cell volume and concentration of Escherichia coli to facilitate data conversion for systems biology modeling.

Carbon-13 labelling strategy for studying the ATP metabolism in individual yeast cells by micro-arrays for mass spectrometry.

A flux-sensing mechanism could regulate the switch between respiration and fermentation.

System-level insights into yeast metabolism by thermodynamic analysis of elementary flux modes.

Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform.

Multidimensional optimality of microbial metabolism.

Prediction of microbial growth rate versus biomass yield by a metabolic network with kinetic parameters.

Functioning of a metabolic flux sensor in Escherichia coli.

Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast.

Dissecting specific and global transcriptional regulation of bacterial gene expression.

Construction and use of a microfluidic dissection platform for long-term imaging of cellular processes in budding yeast.

Mass spectrometry-based metabolomics of single yeast cells.