Lawrence Lum

Immune Modulation in Cancer Patients After Adoptive Transfer of Anti-CD3/Anti-CD28-Costimulated T Cells-Phase I Clinical Trial.

The new stem cell biology.

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

Potential role for ADAM15 in pathological neovascularization in mice.

Phase I/II study of treatment of stage IV breast cancer with OKT3 x trastuzumab-armed activated T cells.

Future prospects for patient care utilizing autologous lymphoid and hematopoietic stem cells.

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

Differentiation hotspots: the deterioration of hierarchy and stochasm.

Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium.

Redirected T-cell cytotoxicity to epithelial cell adhesion molecule-overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model.

How important is HER2/neu amplification and expression when selecting patients for HER2/neu-targeted therapies?

The Hedgehog response network: sensors, switches, and routers.

Anti-CD3 x anti-HER2 bispecific antibody effectively redirects armed T cells to inhibit tumor development and growth in hormone-refractory prostate cancer-bearing severe combined immunodeficient beige mice.

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.

T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B cells and bypass complement-mediated rituximab resistance in vitro.

Preclinical studies comparing different bispecific antibodies for redirecting T cell cytotoxicity to extracellular antigens on prostate carcinomas.

Virtual reality of stem cell transplantation to repair injured myocardium.

Retargeting T cells and immune effector cells with bispecific antibodies.

Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model.

The new face of bispecific antibodies: targeting cancer and much more.

Human T cells armed with Her2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation.

Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study.

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.

A genomewide screen for components of the RNAi pathway in Drosophila cultured cells.

Prevalence of off-target effects in Drosophila RNA interference screens.

Minimizing the risk of reporting false positives in large-scale RNAi screens.

Antibody targeting of stem cells to infarcted myocardium.

Tissue engineering and stem cell therapy for myocardial repair.

Deconstructing the hedgehog pathway in development and disease.

Hedgehog signaling pathway.

Hedgehog signaling pathway in Drosophila.

Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction.

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

Nonabsorbable corticosteroids use in the treatment of gastrointestinal graft-versus-host disease.

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Chemical and biological studies of nakiterpiosin and nakiterpiosinone.

Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited.

Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart.

Cancer therapy with bispecific antibodies: Clinical experience.

Tankyrase is necessary for canonical Wnt signaling during kidney development.

Detection of oseltamivir resistance during treatment of 2009 H1N1 influenza virus infection in immunocompromised patients: utility of cycle threshold values of qualitative real-time reverse transcriptase PCR.

Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways.

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells.

Induction of specific cellular and humoral responses against renal cell carcinoma after combination therapy with cryoablation and granulocyte-macrophage colony stimulating factor: a pilot study.

In vitro synthesis of primary specific anti-breast cancer antibodies by normal human peripheral blood mononuclear cells.

Activated T cells from umbilical cord blood armed with anti-CD3 × anti-CD20 bispecific antibody mediate specific cytotoxicity against CD20+ targets with minimal allogeneic reactivity: a strategy for providing antitumor effects after cord blood transplants.

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.

A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells.

Targeting T cells with bispecific antibodies for cancer therapy.

Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity.

The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent.

Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: a phase II trial.

Targeting cytomegalovirus-infected cells using T cells armed with anti-CD3 × anti-CMV bispecific antibody.

Melphalan 180 mg/m2 can be safely administered as conditioning regimen before an autologous stem cell transplantation (ASCT) in multiple myeloma patients with creatinine clearance 60 mL/min/1.73 m2 or lower with use of palifermin for cytoprotection: results of a phase I trial.

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains.

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Anti-CD3 × anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets.

Anti-thymocyte globulin (thymoglobulin), tacrolimus, and sirolimus as acute graft-versus-host disease prophylaxis for unrelated hematopoietic stem cell transplantation.

Generation and immunologic functions of Th17 cells in malignant gliomas.

Phase I trial of bortezomib during maintenance phase after high dose melphalan and autologous stem cell transplantation in patients with multiple myeloma.

A phase I dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal renal function.

Cell biology. The unusual case of Porcupine.

Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells.

The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids.

Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway.

Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies.

The development of highly potent inhibitors for porcupine.

A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.

Development and prospects for bispecific antibody-based therapeutics in cancer and other applications.

Signaling: Making a leaner Hedgehog.

CD20-Targeted T Cells after Stem Cell Transplantation for High Risk and Refractory Non-Hodgkin's Lymphoma.

Evaluating the effects of lenalidomide induction therapy on peripheral stem cells collection in patients undergoing autologous stem cell transplant for multiple myeloma.