Saveetha university
2 ARTICLES PUBLISHED IN JoVE
Bioengineering
Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Sougata Ghosh 1,2,3, Tanay Bhagwat 3, Rohini Kitture 4, Sirikanjana Thongmee 1, Thomas J. Webster 3,5,6,7
1Department of Physics, Faculty of Science, Kasetsart University, 2Department of Microbiology, School of Science, RK. University, 3Department of Chemical Engineering, Northeastern University, 4Defence Institute of Advanced Technology Campus, Navyukti Innovations Pvt. Ltd., 5Department of Biomedical Engineering, Hebei University of Technology, 6Department of Chemistry, Saveetha School of Engineering, Institute of Medical and Technical Science, Saveetha University, 7UFPI - Universidade Federal do Piauí
Novel nanocomposites of graphene nanoribbons and hydroxyapatite nanoparticles were prepared using solution-phase synthesis. These hybrids when employed in bioactive scaffolds can exhibit potential applications in tissue engineering and bone regeneration.
Medicine
Developing and Testing Methylated Nano-Structured Dipeptides that Inhibit Src Kinase Activity In Vitro for Anti-Cancer Applications
Alaa F. Nahhas 1, Alrayan F. Nahhas 2, Thomas J. Webster 3,4,5
1Biochemistry Department, College of Science, King Abdulaziz University, 2Independent Scholar, 3School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 4School of Engineering, Saveetha University, 5Programa de Pós-graduação em Ciência e Engenharia dos Materiais, UFPI
Presented here is a protocol for designing and testing dipeptides that can inhibit Src kinase enzyme activity using acellular and cellular assays for anti-cancer applications. The peptides formulated here (W-RCH3, WCH3-RCH3, and W-R(CH3)2) inhibited Src kinase with IC50 values of 510 nM, 916 nM, and 1 µM, respectively.
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