Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation FailureLu Chen 1, Loucia Kit Ying Chan 1, Stacey Chui Yiu Wong 1, Joshua Jing Xi Li 2, Jacqueline Pui Wah Chung 1, Chi Chiu Wang 1,3,4,5, Mingqing Li 6,7,8, Tao Zhang 1
1Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, 2Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, 3Reproduction and Development Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, 4School of Biomedical Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, 5Chinese University of Hong Kong - Sichuan University Joint Laboratory in Reproductive Medicine, The Chinese University of Hong Kong, 6Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, 7NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 8Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University
This study presents a pioneering method for quantifying uterine natural killer cell subsets during the window of implantation using advanced multiplexed fluorescent immunohistochemical staining techniques.
