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Veterans Affairs Medical Center, San Francisco

1 ARTICLES PUBLISHED IN JoVE

JoVE Core

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Hugh Alley^1,2,3, Christopher D. Owens^1,2,3, Warren J. Gasper^1,2,3, S. Marlene Grenon^1,2,3

¹Department of Surgery, University of California, San Francisco, ²Department of Surgery, Veterans Affairs Medical Center, San Francisco, ³VipeRx Lab, Veterans Affairs Medical Center, San Francisco

Endothelial dysfunction is associated with numerous disease states and is predictive of adverse cardiovascular events in humans. Flow-mediated vasodilation (FMD) is a non-invasive ultrasound method of evaluating endothelial function. Methodological choices and operator experience may affect results. A systematic approach to FMD in human studies is discussed here.