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Veterans Affairs Boston Healthcare System

3 ARTICLES PUBLISHED IN JoVE

Medicine

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Gabriella Garcia^1,2, Catherine Norise^1,2, Olufunsho Faseyitan^1,2, Margaret A. Naeser^3,4,5, Roy H. Hamilton^1,2

¹Department of Neurology, Perelman School of Medicine, University of Pennsylvania , ²Center for Cognitive Neuroscience, University of Pennsylvania , ³Veterans Affairs Boston Healthcare System, ⁴Harold Goodglass Aphasia Research Center, Boston University School of Medicine, ⁵Department of Neurology, Boston University School of Medicine

We explore the use of repetitive transcranial magnetic stimulation (rTMS) to improve language abilities in patients with chronic stroke and non-fluent aphasia. After identifying a site in the right frontal gyrus for each patient that responds optimally to stimulation, we target this site during ten days of rTMS treatment.

Medicine

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Saran Lotfollahzadeh¹, Mengwei Zhang¹, Marc Arthur Napoleon¹, Wenqing Yin¹, Josephine Orrick¹, Nagla Elzind¹, Austin Morrissey¹, Isaac E. Sellinger¹, Lauren D. Stern¹, Mostafa Belghasem², Jean M. Francis¹, Vipul C. Chitalia^1,3,4

¹Renal Section, Department of Medicine, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, ²Department of Biomedical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, ³Veterans Affairs Boston Healthcare System, ⁴Institute of Medical Engineering and Sciences, Massachusetts Institute of Technology

This article describes modifications of a procedure to implant a peritoneal dialysis catheter in a murine model to avoid major technical issues observed with the conventional techniques.

Cancer Research

Venous Thrombosis Assay in a Mouse Model of Cancer

Saran Lotfollahzadeh¹, Xiaosheng Yang¹, David Jasen Wu Wong¹, Jingyan Han², Francesca Seta², Suvranu Ganguli³, Asha Jose¹, Katya Ravid^4,5, Vipul C. Chitalia^1,6,7,8

¹Renal Section, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, ²Vascular Biology Section, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University, ³Division of Interventional Radiology, Department of Radiology, Chobanian and Avedisian School of Medicine, Boston University, ⁴Department of Medicine, Whitaker Cardiovascular Institute, Chobanian and Avedisian School of Medicine, Boston University, ⁵Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University, ⁶Veterans Affairs Boston Healthcare System, ⁷Institute of Medical Engineering and Sciences, Massachusetts Institute of Technology, ⁸Center of Cross-Organ Vascular Pathology, Department of Medicine, Chobanian and Avedisian School of Medicine, Boston University

This article aims to present an optimized method for assessing venous thrombosis in a mouse cancer model, using vascular clips to achieve venous ligation. Optimization minimizes variability in thrombosis-related measurements and enhances relevance to human cancer-associated venous thrombosis.