Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing ModelYuka Kato 1, Takanori Iwata 2, Kaoru Washio 2, Toshiyuki Yoshida 2, Hozue Kuroda 2, Shunichi Morikawa 3, Mariko Hamada 1, Kazuki Ikura 1, Nobuyuki Kaibuchi 2, Masayuki Yamato 2, Teruo Okano 2, Yasuko Uchigata 1
1Diabetic Center, Tokyo Women's Medical University School of Medicine, 2The Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 3The Department of Anatomy and Developmental Biology, Tokyo Women's Medical University School of Medicine
Adipose-derived stem cells (ASCs) are easily isolated and harvested from the fat of normal rats. ASC sheets can be created using cell-sheet engineering and can be transplanted into Zucker diabetic fatty rats exhibiting full-thickness skin defects with exposed bone and then covered with a bilayer of artificial skin.
