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University of Medicine and Pharmacy

3 ARTICLES PUBLISHED IN JoVE

Medicine

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Sakine Simsekyilmaz¹, Fabian Schreiber², Stefan Weinandy³, Felix Gremse⁴, Tolga Taha Sönmez⁵, Elisa A. Liehn¹

¹Institute for Molecular Cardiovascular Research, RWTH Aachen University, ²Institute for Textile Technology and Mechanical Engineering, RWTH Aachen University, ³Institute for Applied Medical Engineering, Helmholtz-Institute of RWTH Aachen University, ⁴Department of Experimental Molecular Imaging, RWTH Aachen University, ⁵Department of Oral and Maxillofacila Surgery, RWTH Aachen University

A model of stent implantation in mouse carotid artery is described. Compared to other similar methods, this procedure is very rapid, simple and accessible, offering the possibility to study in a convenient way the vascular wall reaction to different drug-eluting stents and the molecular mechanisms of restenosis.

Medicine

Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model

Adelina Curaj¹, Wu Zhoujun¹, Mareike Staudt¹, Elisa A. Liehn^1,2

¹Institute for Molecular Cardiovascular Research, RWTH Aachen University, ²Human Genetic Laboratory, University of Medicine and Pharmacy

This study describes an invasive procedure for the induction of accelerated atherosclerosis in mice. In comparison to other methods using electric- or cryo-induced injury, mechanical-induced injury mimics the human condition of restenosis after revascularization therapies and is ideal for the study of the molecular mechanisms involved.

Medicine

Using the Sleeve Technique in a Mouse Model of Aortic Transplantation - An Instructional Video

Zuzanna Rowinska^1,2, Simone Gorressen³, Marc W. Merx⁴, Thomas A. Koeppel⁵, Alma Zernecke⁶, Elisa A. Liehn²

¹Department of Vascular Surgery and Interdisciplinary Vein Center, St. Josef-Hospital, Ruhr- University Bochum, ²Institute of Molecular Cardiovascular Research, University Hospital, RWTH Aachen University Department of Medicine, ³Institute of Pharmacology and Clinical Pharmacology, Düsseldorf University Hospital, ⁴Department of Cardiology, Vascular Medicine and Intensive Care Medicine, Hospital Robert Koch Gehrden, ⁵Division of Vascular Surgery, Asklepios Klinik St. Georg, ⁶Institute of Experimental Biomedicine, Würzburg University

We present an orthotopic aortic transplantation model using the sleeve technique in mice. It is a very rapid anastomosis method, which can be employed in studies of vascular disease.