Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated NeurotoxicityQiangqiang Wang *1, Ju Zhang *2, Yiyi Jiang 1,3, Yue Xiao 1, Xiaomin Li 3, Xinliang Mao 3, Zebo Huang 1
1Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, 2School of Bioscience and Bioengineering, Hebei University of Economics and Business, 3Perfect Life & Health Institute
Here, we present a protocol to assess the neuroprotective activities of test compounds in Caenorhabditis elegans, including polyglutamine aggregation, neuronal death, and chemoavoidance behavior, as well as an exemplary integration of multiple phenotypes.
