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University of Duesseldorf

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

Saleta Sierra¹, Rolf Kaiser¹, Nadine Lübke¹, Alexander Thielen², Eugen Schuelter¹, Eva Heger¹, Martin Däumer³, Stefan Reuter⁴, Stefan Esser⁵, Gerd Fätkenheuer⁶, Herbert Pfister¹, Mark Oette⁷, Thomas Lengauer²

¹Institute of Virology, University of Cologne, ²Max Planck Institute for Informatics, ³Institute for Immune genetics, ⁴Department of Gastroenterology, Hepatology and Infectiology, University of Duesseldorf, ⁵Department of Dermatology, University of Essen, ⁶Department of Internal Medicine, University of Cologne, ⁷Augustinerinnen Hospital

The prediction of the coreceptor usage of HIV-1 is required for the administration of a new class of antiretroviral drugs, i.e. coreceptor antagonists. It can be performed by sequence analysis of the env gene and subsequent interpretation through an internet based interpretation system (geno2pheno_[coreceptor]).

JoVE Journal

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using ¹⁸F-FDG PET

Alexander Grabner^*1, Dominik Kentrup^*1, Uta Schnöckel², Gert Gabriëls¹, Rita Schröter¹, Hermann Pavenstädt¹, Otmar Schober², Eberhard Schlatter¹, Michael Schäfers^*3, Stefan Reuter^*1

¹Department of Internal Medicine D, Experimental Nephrology, University of Münster, ²Department of Nuclear Medicine, University of Münster, ³European Institute for Molecular Imaging, University of Münster

We herein present a rat renal transplantation model to non-invasively assess acute allograft rejection using positron emission tomography with 18F-fluorodeoxyglucose.