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VA Puget Sound

1 ARTICLES PUBLISHED IN JoVE

Behavior

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Marcella M. Cline¹, Megan A. Ostlie², Chloe G. Cross³, Gregory G. Garwin², Satoshi Minoshima², Donna J. Cross²

¹Department of Radiology, University of Washington, ²Department of Radiology, University of Utah, ³Geriatric Research Education and Clinical Center (GRECC), VA Puget Sound

Here we present a protocol for a mouse-specific test of cognition that does not require swimming. This test can be used to successfully distinguish controlled cortical impact-induced traumatic brain injury mice from sham controls.