A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue RegenerationChao Xiong 1, Zhiquan Zhang 1, Gurpreet S. Baht 2,3, Niccolo Terrando 1,4
1Department of Anesthesiology, Duke University Medical Center, 2Department of Orthopaedic Surgery, Duke University Medical Center, 3Duke Molecular Physiology Institute, 4Center for Translational Pain Medicine, Duke University Medical Center
This protocol describes a mouse model of orthopedic surgery that has been used to study mechanisms of postoperative neuroinflammation and behavioral changes, and when combined with parabiosis, to study tissue regeneration during aging.
