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Florida Atlantic University, John D MacArthur Campus

1 ARTICLES PUBLISHED IN JoVE

Behavior

Swimming Induced Paralysis to Assess Dopamine Signaling in Caenorhabditis elegans

Sirisha Kudumala¹, Serena Sossi², Lucia Carvelli^1,3,4

¹Harriet Wilkes Honors College, Florida Atlantic University, John D MacArthur Campus, ²Integrative Biology and Neuroscience program, College of Science, Florida Atlantic University, ³Brain Institute, Florida Atlantic University, ⁴Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University

Swimming induced paralysis (SWIP) is a well-established behavioral assay used to study the underlying mechanisms of dopamine signaling in Caenorhabditis elegans (C. elegans). However, a detailed method to perform the assay is lacking. Here, we describe a step-by-step protocol for SWIP.