Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV InfectionAnna H. F. Andersen 1,2, Stine S. F. Nielsen 1,2, Rikke Olesen 1,2, Katharina Mack 1, Frederik Dagnæs-Hansen 3, Niels Uldbjerg 1,4, Lars Østergaard 1,2, Ole S. Søgaard 1,2, Paul W. Denton 1,2,5, Martin Tolstrup 1,2
1Department of Clinical Medicine, Aarhus University, 2Department of Infectious Diseases, Aarhus University Hospital, 3Department of Biomedicine, Aarhus University, 4Department of Gynecology and Obstetrics, Aarhus University Hospital, 5Department of Biology, University of Nebraska at Omaha
We have developed a protocol for the generation and evaluation of a humanized and human immunodeficiency virus-infected NOG mouse model based on stem cell transplant, intravaginal human immunodeficiency virus exposure, and droplet digital PCR RNA quantification.
