Decellularization for the Preparation of Highly Preserved Human Acellular Skin Matrix for Regenerative MedicineVeronica Romano *1, Immacolata Belviso *1, Domenico Cozzolino 1, Anna Maria Sacco 1, Fabrizio Schonauer 1, Daria Nurzynska 2, Franca Di Meglio 1, Clotilde Castaldo 1
1Department of Public Health, University of Naples Federico II, Naples, Italy, 2Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy
Decellularized human skin is suitable for tissue regeneration. A major issue of decellularization is the preservation of the native architecture, along with the appropriate content of structural proteins, glycosaminoglycans (GAGs), and growth factors. The method proposed allows fast and effective decellularization, producing decellularized skin with well-preserved native features.
