Bölüm 23
Kinaz Reseptörlerinin Sinyal Ağları
Reseptör Tirozin Kinazlar
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, ...
Küçük GTPazlar - Ras ve Rho
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases ...
MAPK Sinyalizasyon Kaskadları
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, ...
JAK-STAT Sinyalizasyon Yolu
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, ...
PI3K/mTOR/AKT Sinyalizasyon Yolu
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to ...
TGF - β Sinyalizasyon Yolu
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β ...
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