Chapter 8
Nonlinear Pharmacokinetics
Doğrusal Olmayan Farmakokinetik: Genel Bakış
Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...
Doğrusal Olmayan Farmakokinetik: Doğrusal Olmayanlığın Nedenleri
Various factors contribute to nonlinearity in drug pharmacokinetics.
Nonlinearity in drug absorption may result from rate-limited solubility, ...
Doğrusal Olmayan Farmakokinetik: Michaelis-Menten Denklemi
The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism.
It determines the rate of decline of drug concentration over time, ...
Michaelis Sabiti ve Maksimum Eliminasyon Oranının Belirlenmesi
The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration.
...
Doğrusal Olmayan Farmakokinetik: IV Bolus Enjeksiyonu için İlaç Eliminasyonu
In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM.
Following an IV bolus, Dt, the amount of drug in the body at any ...
Tek Bölmeli Model Olarak İlaç Dağılımı ve Doğrusal Olmayan Farmakokinetik ile Eliminasyon: Genel Bakış
Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes.
The metabolism of drugs ...
Doğrusal Olmayan Eliminasyonu Etkileyen Parametreler: Sıfır Mertebeden Giriş, Birinci Mertebeden Absorpsiyon ve İki Bölmeli Model
Drugs administered through different administration routes follow nonlinear elimination.
Consider a drug administered through a constant IV infusion, ...
Doğrusal Olmayan Farmakokinetik: Eliminasyon Yarılanma Ömrü ve Doz Klerensine Bağımlılık
Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics.
The elimination half-life is influenced by the ...
Kronofarmakokinetik: Sirkadiyen Ritimler ve İlaç Yanıtı Üzerine Etkisi
Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions.
Standard circadian ...
Kronofarmakokinetik: Zamana Bağlı Farmakokinetik
Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical.
Cyclic changes occur over constant ...
Doğrusal Olmayan Farmakokinetik: Biyoyararlanım ve Protein-İlaç Bağlanması
For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate.
A saturable pathway ...
Doğrusal Olmayan Farmakokinetik: Taşıyıcıların Rolü
Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution.
These cellular transporters in cells modulate ...
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