roller microneedle procedure for treating melasma and efficacy evaluation of the procedure

Traneksamik Asit ve Mikroiğneleme Tedavisi ile Melazma Tedavisinin Geliştirilmesi

Melasma, also known as chloasma, is a chronic and acquired facial hyperpigmentation skin condition. Clinically, it presents as symmetrical, light to dark brown patches with unclear borders, distributed on the cheeks, forehead, and jawline. The incidence rate among Asian women of childbearing age can be as high as 30%1. The disease is easily diagnosed but difficult to cure. The pathogenesis of melasma is not yet fully understood, but three main factors contribute to its development: genetic susceptibility, exposure to sunlight, and hormonal changes. Increased melanin synthesis, vascular proliferation at the site of skin lesions, inflammatory reactions, and impaired skin barrier function all play a role in the occurrence of melasma2.
Currently, treatment options for melasma include laser therapy and medications, among which, transdermal administration is a widely used method. However, the main challenge lies in the barrier function of the stratum corneum, which hinders drug penetration. Microneedle therapy creates multiple micro-channels in the skin within a short period, disrupting the stratum corneum, inducing collagen production, and increasing skin permeability. This approach holds promise in allowing drugs to diffuse into the skin and then rapidly reseal, thus avoiding the introduction of toxic or irritating substances3.
Commonly used microneedle tools include the electronic water light injection microneedle, roller microneedle, electrically assisted nanocrystalline microneedle, plum blossom microneedle, and single needle microneedle4. The roller microneedle is characterized by less trauma, good curative effect, convenient operation, and can be combined with some other drugs to treat melasma. It has a good therapeutic prospect for melasma and is worth more promotion and use in clinical practice. This article introduces the operation and precautions of roller microneedles combined with tranexamic acid in the treatment of melasma and demonstrates the efficacy of roller microneedle combined with tranexamic acid in the treatment of melasma through clinical cases.

Yazar Spotlight: Melazmanın Ameliyatsız Tedavisi – Traneksamik Asit ile Mikroiğneleme

Melazma Tedavisinde Traneksamik Asit Çözeltisi ile Birleştirilmiş Rulo Mikroiğne

Our research focus on non-surgery therapy for pigmentated disease. We tested the efficacy of roller microneedling combined with tranexamic acid solution in treating melasma. We will investigate the effectiveness and the max easiness of using a combination of roller microneedles and tranexamic acid solution for treating melasma.

Melazma Tedavisinde Roller Mikroiğne Prosedürü ve İşlemin Etkinlik Değerlendirmesi

Prosedüre başlamak için, terapist uygun hijyeni sağlamak için ellerini yıkamalı, şapka, maske ve steril eldiven takmalıdır. Hastalara gözlerini kapatmalarını söyleyin. Traneksamik asit solüsyonunu cilde uygulamak için bir şırınga kullanın ve elle eşit olarak dağıtın.Silindir mikroiğneyi fizyolojik tuzlu su ile temizleyin ve mikroiğneyi tedavi alanı boyunca yatay, dikey ve çapraz desenlerde kısa mesafelerde yuvarlayın. Emilimi kolaylaştırmak için çözeltinin uygulanmasını haddeleme hareketiyle entegre ederek farklı alanları tedavi edin. Mikroiğneyi sürüklemeden eşit basınç uygularken işlemi üç ila beş kez tekrarlayın, cildin kızarmasını ancak kanamamasını sağlayın.Her seanstan önce ve sonra tedavi etkinliğini değerlendirmek için Multispektral DERMATOSKOP'u kullanın. UV sığ ve derin lekelerin yanı sıra melazma şimşeklerini gösteren kahverengi lekelerin azalmasını izleyerek tedavinin etkinliğini değerlendirin. Tedavi seanslarından önce ve sonra ultraviyole, sığ ve derin lekeler ve kahverengi lekelerdeki değişiklikleri karşılaştırmak için istatistiksel analiz yapın.

roller-microneedle-procedure-for-treating-melasma-efficacy-evaluation

Research

JoVE Journal

Medicine

Roller Microneedle Procedure for Treating Melasma and Efficacy Evaluation of the Procedure

39 Görüntüleme.  Chongqing Hospital of Traditional Chinese Medicine. Prosedüre başlamak için, terapist uygun hijyeni sağlamak için ellerini yıkamalı, şapka, maske ve steril eldiven takmalıdır. Hastalara gözlerini kapatmalarını söyleyin. Traneksamik asit solüsyonunu cilde uygulamak için bir şırınga kullanın ve elle eşit olarak dağıtın.Silindir mikroiğneyi fizyolojik tuzlu su ile temizleyin ve mikroiğneyi tedavi alanı boyunca yatay, dikey ve çapraz desenlerde kısa mesafelerde yuvarlayın. Emilimi kolaylaştırmak için çözel...

Video: Melazma Tedavisinde Roller Mikroiğne Prosedürü ve İşlemin Etkinlik Değerlendirmesi

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes of melasma remain elusive, and the current therapeutic approaches predominantly encompass pharmaceutical and laser interventions, with limited efficacy. Transdermal administration stands as a prevalent treatment method for melasma, often facilitated by the application of microneedles. Among these, tranexamic acid emerges as a frequently employed therapeutic agent. A subset of microneedles, known as roller microneedles, plays a significant role in this approach by delicately puncturing the epidermis with multiple fine needles, synergizing with drug delivery. This methodology not only enhances drug absorption but also augments treatment efficacy while minimizing tissue trauma. These attributes forecast promising avenues for the treatment of melasma. This article primarily introduces the combination of roller microneedle and tranexamic acid solution in the treatment of melasma and demonstrates the efficacy of roller microneedle and tranexamic acid solution in the treatment of melasma through clinical cases.

This article presents a protocol to conduct the treatment of melasma by using roller microneedles in combination with tranexamic acid solution and evaluate the efficacy.

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective ...