Name: Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study
Uploaded: 2023-07-14T13:00:00
Description: Watch this Scientific Journal Video about Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study at JoVE.com

pre-test and bioelectrical impedance analysis measurement for participant classification in cachexia study

Utvikle et treningsprogram for pasienter med revmatoid artritt

Rheumatoid arthritis (RA) is a disabling disease that affects patients&#39; functionality and independence due to acute joint pain, reduced muscle strength, and impaired physical function, all of which are associated with the inflammatory process inherent to the disease1,2. In advanced stages, persistent inflammation causes structural alterations leading to deformity, joint dysfunction, and rheumatoid cachexia, which is a poor prognostic factor for these patients3,4.
Rheumatoid cachexia is characterized by alterations in body composition, such as muscle loss with stable weight and increased fat mass, which can significantly impact the quality of life for these patients3,5,6. Various techniques are available to assess body composition, with the most widely used being bioelectrical impedance analysis (BIA). However, when conventional BIA analysis is used in subjects with altered body compositions, the estimations may be limited as they are based on prediction equations formulated for a healthy or normally hydrated population7,8.
A different approach, called bioelectrical impedance vector analysis (BIVA), utilizes the impedance vector based on graphical RXc. It utilizes impedance, resistance (R), and reactance (Xc) data corrected for height, resulting in a vector that provides information about the hydration state and integrity of the cell mass. BIVA is capable of classifying patients into categories such as dehydration, overhydration, normal, athlete, lean, cachectic, and obese, making it a valuable tool for RA patients8,9,10. Vectors located above or below the main axis (the left or right halves of the ellipses) have been associated with higher and lower cell mass&#160;in soft tissues, respectively. Forward and backward displacements of vectors parallel to the major axis are linked to dehydration and fluid overload. Athletes are defined as individuals with higher cell mass, potentially accompanied by dehydration. The lean classification refers to those with lower cell mass, potentially accompanied by dehydration, and the obese classification applies to individuals with higher cell mass, which may be accompanied by fluid overload. The classification of cachexia by BIVA is determined by high resistance and low reactance values, represented by the movement of the vector to the right of the graph, indicating a decrease in cell mass, potentially accompanied by an alteration in hydration status11 (Figure 1).
Conventional pharmacological treatments for RA primarily focus on reducing pain, inflammation, and joint damage progression, with limited attention given to alterations in body composition12. Among the non-pharmacological therapies commonly used in this population, exercise-based interventions have shown positive outcomes in improving functionality, fatigue, pain, joint mobility, aerobic capacity, muscle strength, endurance, flexibility, and psychological well-being. Importantly, these interventions have been shown to achieve these benefits without exacerbating symptoms or causing joint damage in patients without extensive pre-existing damage13,14,15,16,17. However, there is limited knowledge on implementing and evaluating changes in hydration and body cell mass status following exercise interventions in this population. These patients often experience pain, inflammation, and structural joint changes, limiting the types of activities they can engage in and further complicating body composition assessments using traditional approaches. This protocol aims to demonstrate how to evaluate changes in hydration and body cell mass status using bioelectrical impedance vectorial analysis after implementing a dynamic exercise program for patients with rheumatoid arthritis. Additionally, the protocol provides details of the dynamic exercise program, including cardiovascular capacity, strength, and coordination components, as well as the steps, instruments, limitations, and general considerations.

Forfatter Spotlight: Implementering av BIVA for å analysere sykdomsrisikofaktorer hos pasienter med lav kroppscellemasse 

Evaluering av endringer i hydrering og kroppscellemasse med bioelektrisk impedansanalyse etter treningsprogram for pasienter med revmatoid artritt

The research aims to demonstrate the utility of the vector impedance analysis for assessing change in hydration in body cell mass in patients with rheumatoid arthritis, and to investigate the benefits of physical exercise for this population. Recent research has shown that patients classified with low body cell mass, using bioelectrical impedance vector analysis, have an increased risk of infections and service predictors for cardiovascular diseases. This findings indicate that patients with lower cellular mass as determined by vectorial bioelectrical impedance analysis have a high risk of infections.Additionally, we have observed that physical exercise improves strength and quality of life and reduces inflammation in patient with rheumatoid arthritis. Assessing body composition through vectorial analysis of bioelectrical impedance will enable informed decision in pharmacological treatment. Additionally, integrating physical exercise as part of the treatment aims to prevent or improve a specific alteration associated with changes in body composition.It is crucial to evaluate the long-term effects of body composition alterations in patients with rheumatoid arthritis and demonstrate the effectiveness of physical exercise in increasing cellular mass, which is the most metabolically active human body compartment, which provides a greater functional reserve associated with better prognosis.

Watch this Scientific Journal Video about Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study at JoVE.com

Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study  

Pre-test og bioelektrisk impedansanalyse måling for deltakerklassifisering i kakeksistudie

For å begynne, be pasienten om å fjerne begge skoene, den høyre sokken og eventuelle metallgjenstander som er i kontakt med hudposisjonen. Pasientens liggende i fem minutter med forlengede armer og ben. Rengjør baksiden av hånden og høyre fot med 70% alkohol.For å klassifisere kakeksi etter BIVA, last ned BIVA Tolerance Rxc Graph-programvaren og åpne den. Gå til det andre regnearket kalt Referansepopulasjoner, og velg en rad som tilsvarer referansepopulasjonen. Kopier og lim den deretter inn i den andre raden uthevet i gult.Deretter går du til det femte regnearket med tittelen Emner: og i kolonne A, skriv inn pasientens ID; Og i kolonne B, skriv inn nummer én. I kolonne E, ved bruk av M for menn og F for kvinner, skriv inn pasientens kjønn. I kolonne F og G, skriv inn de tidligere nevnte motstands- og reaktansverdiene ved 50 kilohertz.Skriv deretter inn høyde i centimeter og vekt i kilo i de neste to kolonnene. I kolonne J skriver du inn tallet som tilsvarer referansepopulasjonen som er valgt i det andre regnearket. Etter dette, i kolonne K, skriv inn et tall mellom en og 10 for punktgrafarket.Skriv inn pasientens alder i neste kolonne. Fra alternativlinjen øverst i programvaren, klikk på komplimenter, velg deretter beregnealternativet og klikk på det. Deretter navigerer du til ark tre punktgraf for å observere en BIVA-graf i henhold til den valgte referansepopulasjonen.Når du ser en dialogboks, velger du gruppekoden som er angitt i kolonne K, og klikker deretter OK. En BIVA-graf vises med pasientens vektor tegnet som en geometrisk figur. Deretter observerer du toleranseellipsene på 50, 75 og 95% i kvadrantene I, II, III og IV i BIVA-grafen.

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Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is a debilitating disease that can result in complications such as rheumatoid cachexia. While physical exercise has shown ...