Name: Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study
Uploaded: 2023-07-14T13:00:00
Description: Watch this Scientific Journal Video about Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study at JoVE.com

pre-test and bioelectrical impedance analysis measurement for participant classification in cachexia study

Разработка программы физических упражнений для пациентов с ревматоидным артритом

Rheumatoid arthritis (RA) is a disabling disease that affects patients&#39; functionality and independence due to acute joint pain, reduced muscle strength, and impaired physical function, all of which are associated with the inflammatory process inherent to the disease1,2. In advanced stages, persistent inflammation causes structural alterations leading to deformity, joint dysfunction, and rheumatoid cachexia, which is a poor prognostic factor for these patients3,4.
Rheumatoid cachexia is characterized by alterations in body composition, such as muscle loss with stable weight and increased fat mass, which can significantly impact the quality of life for these patients3,5,6. Various techniques are available to assess body composition, with the most widely used being bioelectrical impedance analysis (BIA). However, when conventional BIA analysis is used in subjects with altered body compositions, the estimations may be limited as they are based on prediction equations formulated for a healthy or normally hydrated population7,8.
A different approach, called bioelectrical impedance vector analysis (BIVA), utilizes the impedance vector based on graphical RXc. It utilizes impedance, resistance (R), and reactance (Xc) data corrected for height, resulting in a vector that provides information about the hydration state and integrity of the cell mass. BIVA is capable of classifying patients into categories such as dehydration, overhydration, normal, athlete, lean, cachectic, and obese, making it a valuable tool for RA patients8,9,10. Vectors located above or below the main axis (the left or right halves of the ellipses) have been associated with higher and lower cell mass&#160;in soft tissues, respectively. Forward and backward displacements of vectors parallel to the major axis are linked to dehydration and fluid overload. Athletes are defined as individuals with higher cell mass, potentially accompanied by dehydration. The lean classification refers to those with lower cell mass, potentially accompanied by dehydration, and the obese classification applies to individuals with higher cell mass, which may be accompanied by fluid overload. The classification of cachexia by BIVA is determined by high resistance and low reactance values, represented by the movement of the vector to the right of the graph, indicating a decrease in cell mass, potentially accompanied by an alteration in hydration status11 (Figure 1).
Conventional pharmacological treatments for RA primarily focus on reducing pain, inflammation, and joint damage progression, with limited attention given to alterations in body composition12. Among the non-pharmacological therapies commonly used in this population, exercise-based interventions have shown positive outcomes in improving functionality, fatigue, pain, joint mobility, aerobic capacity, muscle strength, endurance, flexibility, and psychological well-being. Importantly, these interventions have been shown to achieve these benefits without exacerbating symptoms or causing joint damage in patients without extensive pre-existing damage13,14,15,16,17. However, there is limited knowledge on implementing and evaluating changes in hydration and body cell mass status following exercise interventions in this population. These patients often experience pain, inflammation, and structural joint changes, limiting the types of activities they can engage in and further complicating body composition assessments using traditional approaches. This protocol aims to demonstrate how to evaluate changes in hydration and body cell mass status using bioelectrical impedance vectorial analysis after implementing a dynamic exercise program for patients with rheumatoid arthritis. Additionally, the protocol provides details of the dynamic exercise program, including cardiovascular capacity, strength, and coordination components, as well as the steps, instruments, limitations, and general considerations.

В центре внимания автора: Внедрение BIVA для анализа факторов риска заболевания у пациентов с низкой массой клеток тела 

Оценка изменений гидратации и клеточной массы организма с помощью анализа биоэлектрического импеданса после программы физических упражнений у пациентов с ревматоидным артритом

The research aims to demonstrate the utility of the vector impedance analysis for assessing change in hydration in body cell mass in patients with rheumatoid arthritis, and to investigate the benefits of physical exercise for this population. Recent research has shown that patients classified with low body cell mass, using bioelectrical impedance vector analysis, have an increased risk of infections and service predictors for cardiovascular diseases. This findings indicate that patients with lower cellular mass as determined by vectorial bioelectrical impedance analysis have a high risk of infections.Additionally, we have observed that physical exercise improves strength and quality of life and reduces inflammation in patient with rheumatoid arthritis. Assessing body composition through vectorial analysis of bioelectrical impedance will enable informed decision in pharmacological treatment. Additionally, integrating physical exercise as part of the treatment aims to prevent or improve a specific alteration associated with changes in body composition.It is crucial to evaluate the long-term effects of body composition alterations in patients with rheumatoid arthritis and demonstrate the effectiveness of physical exercise in increasing cellular mass, which is the most metabolically active human body compartment, which provides a greater functional reserve associated with better prognosis.

Watch this Scientific Journal Video about Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study at JoVE.com

Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study  

Предтестовое измерение и биоэлектрический импедансный анализ для классификации участников в исследовании кахексии

Для начала попросите пациента снять обе обуви, правый носок и все металлические предметы, которые соприкасаются с его кожей. Пациент лежит на спине в течение пяти минут с вытянутыми руками и ногами. Очистите тыльную сторону кисти и правую ногу 70%-ным спиртом.Чтобы классифицировать кахексию по BIVA, загрузите программное обеспечение BIVA tolerance Rxc Graph и откройте его. Перейдите ко второму листу под названием Ссылочные популяции и выберите строку, соответствующую ссылочной совокупности. Затем скопируйте и вставьте его во вторую строку, выделенную желтым цветом.Далее переходим к пятому рабочему листу под названием «Субъекты» и в столбце «А» вводим идентификатор пациента, а в столбце «Б» вводим цифру один. В графе E, используя M для мужчин и F для женщин, введите пол пациента. В столбцы F и G введите ранее отмеченные значения сопротивления и реактивного сопротивления на частоте 50 килогерц.Затем в следующих двух столбцах введите рост в сантиметрах и вес в килограммах. В столбце J введите число, соответствующее ссылочной совокупности, выбранной на втором листе. После этого в столбце K введите число от одного до 10 для листа точечной диаграммы.Введите возраст пациента в следующем столбце. На панели параметров в верхней части программного обеспечения нажмите на комплименты, затем выберите опцию «Рассчитать» и нажмите на нее. Затем перейдите к трехточечному графику листа, чтобы просмотреть график BIVA в соответствии с выбранной референтной совокупностью.Открыв диалоговое окно, выберите код группы, введенный в столбце K, и нажмите кнопку ОК. Отображается график BIVA с вектором пациента, нарисованным в виде геометрической фигуры. Затем обратите внимание на эллипсы допусков 50, 75 и 95% в квадрантах I, II, III и IV на графике BIVA.

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JoVE Journal

Medicine

Pre-Test and Bioelectrical Impedance Analysis Measurement for Participant Classification in Cachexia Study

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is a debilitating disease that can result in complications such as rheumatoid cachexia. While physical exercise has shown ...