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Silicone Rubber Compound Injection and Tissue Harvest to Assess Vessel Dilatation in Neurodegenerative Diseases

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01:32 min

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May 17th, 2024

DOI :

10.3791/201848-v

May 17th, 2024

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Dominic Simpson¹^,², Christopher D. Morrone¹, Darcy Wear¹^,², Jose Gutierrez³, Wai Haung Yu²

¹Brain Health Imaging Centre, Centre for Addiction and Mental Health, ²Department of Pharmacology and Toxicology, University of Toronto, ³Department of Neurology, Columbia University

Transcript

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Silicone Rubber Compound

Vessel Dilatation

Neurodegenerative Diseases

Anesthetized Mouse

Heart Perfusion

23 Gauge Needle

Silicone Solution

Paraformaldehyde

Brain Incubation

Basilar Artery Enlargement

Elastase Injection

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