Name: methods to quantify pharmacologically induced alterations in motor function in human incomplete sci
Uploaded: 2011-04-18T13:00:00
Duration: 14 min 55 s
Description: Watch this Scientific Journal Video about Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI at JoVE.com

NIH R21NS42516 к TGH Крейг H Nielsen Фонда Грант 83860 до TGH NIDRR-РКАТ. АПТА Докторантура стипендий CKT

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Нет конфликта интересов объявлены.

Это видео демонстрации подчеркивает методы для оценки изменений в рефлекторной деятельности, волевых сил и передвигаться следующие острые перорального приема СИОЗС в человеческой ТСМ. Эта батарея оценок показывает, что несмотря на рост в так называемых ненормальных рефлекторной деятельности после острого перорального приема СИОЗС, человек с ТСМ продемонстрировали улучшение волевых сил, лишь с незначительными изменениями в опорно-двигательной способности. В этих лиц последствия спастичность дополнены не появляются вредные для амбулаторного функции. Кроме того, улучшения в способности ходить может быть более выражен у лиц с острыми поражениями. Продолжая исследования использовать эти аналогичный количественный и клинической оценки для определения эффективности комбинированного СИОЗС и интенсивные физические вмешательства, так как был принят на работу на животных моделях ТСМ. С солидной теоретической базы, основанной на долгосрочных и относительно новые фундаментальные исследования науки, эти методы могут помочь перевести такую ​​информацию клинических населения и могут оспорить некоторые традиционные протоколы, используемые в клинической практике для увеличения функциональное восстановление у пациентов с ТСМ.

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methods to quantify pharmacologically induced alterations in motor function in human incomplete sci

Spinal cord injury (SCI) is a debilitating disorder, which produces profound deficits in volitional motor control. Following medical stabilization, recovery from SCI typically involves long term rehabilitation. While recovery of walking ability is a primary goal in many patients early after injury, those with a motor incomplete SCI, indicating partial preservation of volitional control, may have the sufficient residual descending pathways necessary to attain this goal. However, despite physical interventions, motor impairments including weakness, and the manifestation of abnormal involuntary reflex activity, called spasticity or spasms, are thought to contribute to reduced walking recovery. Doctrinaire thought suggests that remediation of this abnormal motor reflexes associated with SCI will produce functional benefits to the patient. For example, physicians and therapists will provide specific pharmacological or physical interventions directed towards reducing spasticity or spasms, although there continues to be little empirical data suggesting that these strategies improve walking ability.
In the past few decades, accumulating data has suggested that specific neuromodulatory agents, including agents which mimic or facilitate the actions of the monoamines, including serotonin (5HT) and norepinephrine (NE), can initiate or augment walking behaviors in animal models of SCI. Interestingly, many of these agents, particularly 5HTergic agonists, can markedly increase spinal excitability, which in turn also increases reflex activity in these animals. Counterintuitive to traditional theories of recovery following human SCI, the empirical evidence from basic science experiments suggest that this reflex hyper excitability and generation of locomotor behaviors are driven in parallel by neuromodulatory inputs (5HT) and may be necessary for functional recovery following SCI. 
The application of this novel concept derived from basic scientific studies to promote recovery following human SCI would appear to be seamless, although the direct translation of the findings can be extremely challenging. Specifically, in the animal models, an implanted catheter facilitates delivery of very specific 5HT agonist compounds directly onto the spinal circuitry. The translation of this technique to humans is hindered by the lack of specific surgical techniques or available pharmacological agents directed towards 5HT receptor subtypes that are safe and effective for human clinical trials. However, oral administration of commonly available 5HTergic agents, such as selective serotonin reuptake inhibitors (SSRIs), may be a viable option to increase central 5HT concentrations in order to facilitate walking recovery in humans. Systematic quantification of how these SSRIs modulate human motor behaviors following SCI, with a specific focus on strength, reflexes, and the recovery of walking ability, are missing.
This video demonstration is a progressive attempt to systematically and quantitatively assess the modulation of reflex activity, volitional strength and ambulation following the acute oral administration of an SSRI in human SCI. Agents are applied on single days to assess the immediate effects on motor function in this patient population, with long-term studies involving repeated drug administration combined with intensive physical interventions.

Watch this Scientific Journal Video about Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI at JoVE.com

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Это видео демонстрирует модуляции рефлекторной деятельности, волевых сил и передвигаться по клиническим и количественные оценки у лиц с неполной ТСМ двигателя в результате острого перорального приема ингибитор обратного захвата серотонина (SSRI).

Методы количественного Фармакологически индуцированные Изменения в моторной функции в человеческой Неполные SCI

Spinal cord injury (SCI) is a debilitating disorder, which produces profound deficits in volitional motor control. Following medical stabilization, ...

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