Name: intra-operative behavioral tasks in awake humans undergoing deep brain stimulation surgery
Uploaded: 2011-01-06T16:00:00
Description: Watch this Scientific Journal Video about Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery at JoVE.com

1。除招聘和同意<ol><li>临床评价和丘脑底核（STN）的深部脑刺激难治性帕金森病（DBS）的同意后，每个病人的信息是审查，以确定如果他/她符合的手术研究（定义在一个机构审查的标准董事会批准在马萨诸塞州总医院的协议）。 </li><li>如果确定的主题，符合研究标准，医生的研究组成员（而不是操作系统的外科医生）方法的病人参与研究讨论的可能性。 </li><li>参与研究的同意书，然后检讨和?...

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深部脑刺激手术提供了宝贵的机会，在人类大脑研究单个神经元的活动。迄今为止，这个机会已经允许不同深核活动的许多特征的描述性研究。最近，手术的任务变得更加复杂，以解决各方面的行为和认知。当前协议的目的是提供一个成功实施手术的行为任​​务的指导。的目标任务和研究的目的，当然取决于手术有针对性的细胞核。鉴于越来越多的星展手术的应用和相应增加的各种目标，我们?...

*表示，这个项目可以替代通过类似的设备或软件; **表示，替代国家仪器组件都可以使用（参考<a href="www.Monkeylogic.net">www.Monkeylogic.net</a>的兼容性）; ***请以<a href="www.Monkeylogic.net">www.Monkeylogic.net</a> Matlab的具体要求toolboxs。

intra-operative behavioral tasks in awake humans undergoing deep brain stimulation surgery

脑深部刺激（DBS）是一种外科手术，引导长期，高频电刺激大脑中植入电极通过的具体目标。脑深部电刺激已开始实施，作为一个Benabid等治疗方法 。在80年代后期，当他使用这种技术来刺激治疗震颤 1丘脑腹中间核。目前，该过程是用来治疗的患者未能充分应对疾病，如帕金森氏症，肌张力障碍，原发性震颤医疗管理。此过程为治疗帕金森氏病的疗效已被证实在供电，随机对照试验。目前，美国食品和药物管理局已批准星展作为难治的原发性震颤，帕金森氏症，和肌张力障碍患者的治疗。此外，新加坡发展银行（DBS）是目前正在评估其他精神和神经系统疾病的治疗，如强迫症，抑郁症的主要，和癫痫。 星展不仅得到了显示，以帮助人们改善他们的生活质量，还提供独特的机会，学习和了解人类大脑的研究人员。微电极的录音进行例行星展手术期间，以提高解剖定位精度。因此，可以记录单个神经元的放电模式，而受执行行为的任务。使用集中描述的各个方面，包括射击和爆裂率和频率调制3这些数据的早期研究。最近的研究都集中在认知行为方面的有关神经元的活动4,5。本文将提供用于执行行为任务和神经元的数据记录与清醒患者，在星展案件的手术方法的说明。收购电数据的过程中的论述，将照亮我们目前的范围和手术的人体实验的局限性。

Watch this Scientific Journal Video about Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery at JoVE.com

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

深部脑刺激术，研究人类大脑在清醒信息编码提供了一个独特的机会。本文将介绍手术的方法，用于执行任务的认知和行为，同时获得的生理数据，如肌电图，单神经元单位活动和​​/或当地的场电位。

在接受深部脑刺激手术术中唤醒人类行为任务

Deep brain stimulation (DBS) is a surgical procedure that directs chronic, high frequency electrical stimulation to specific targets in the brain through ...

Research

JoVE Journal

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The rise of accessible commercial eye-tracking systems has fueled a rapid increase in their use in psychological and psychiatric research. By providing a ...

科研

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Intranasal Administration of CNS Therapeutics to Awake Mice

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Intranasal administration is a method of delivering  therapeutic agents to the central nervous system (CNS). It is  non-invasive and allows large ...

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

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Examining molecular mechanisms involved in neuropathological conditions, such as ischemic stroke, can be difficult when using whole animal systems. As ...

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

控制帕金森氏症与自适应深部脑刺激

Adaptive deep brain stimulation (aDBS) has the potential to improve the treatment of Parkinson&#39;s disease by optimizing stimulation in real time ...

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

使用Saccadometry与深部脑刺激来研究正常和病理脑功能

The oculomotor system involves a large number of brain areas including parts of the basal ganglia, and various neurodegenerative diseases including ...

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Resting-state functional connectivity MRI (rs-fcMRI) is a technique that identifies connectivity between different brain regions based on correlations ...

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

对称Bihemispheric死后的大脑切割学习健康和病理条件大脑在人

Neuropathologists, at times, feel intimidated by the amount of knowledge needed to generate definitive diagnoses for complex neuropsychiatric phenomena ...

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评估在鼠标模型中执行唤醒膀胱测压的过程

Awake filling cystometry has been used for a long time to evaluate bladder function in freely moving mice, however, the specific methods used, vary among ...

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

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Chronic pain following surgery, persistent postsurgical pain, is an important highly prevalent condition contributing to significant symptom burden and ...

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

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Incomplete spinal cord injury (SCI) often leads to impairments of sensorimotor functions and is clinically the most frequent type of SCI. Human ...