Name: corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies
Uploaded: 2011-01-03T17:30:00
Description: Watch this Scientific Journal Video about Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies at JoVE.com

<p class="jove_content">这项工作是支持青少年糖尿病研究基金会国际（批17-2008-1031）和美国国立卫生研究院（授予1R01DK077903 - 01A1）。 </p>

<p class="jove_title">简介： </p><p class="jove_content">周围神经病变的准确定量是很重要的定义处于危险的患者，预期恶化，并评估新的治疗方法。常规方法评估神经功能缺损和电生理和定量感觉测试的量化功能的改变，检测神经病变。然而，最早的损害，出现细小纤维，但这些测试主要是评估大纤维功能障碍，表现出的再生和修复能力有限。只允许直接检查的​​无髓神经纤维的损伤和修复技术，电子显微镜和皮肤打孔?...

<ol>
	<li>Abbott, C. A., Kallinikos, P., Marshall, A., Finnigan, J., Morgan, P., Efron, N., Boulton, A. J. M., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+Confocal+Microscopy:+A+Novel+Non-invasive+Test+to+Diagnose+and+Assess+Progression+of+Human+Diabetic+Neuropathy.">Corneal Confocal Microscopy: A Novel Non-invasive Test to Diagnose and Assess Progression of Human Diabetic Neuropathy.</a> <em style='font-style: italic'>Diabetes Care</em>. <b>33</b>, 1792-1797 (2010).</li><li>Quattrini, C., Tavakoli, M., Jeziorska, M., Kallinikos, P., Tesfaye, S., Marshall, A., Finnigan, J., Boulton, A. J. M., Efron, N., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Surrogate+Markers+of+Small+Fiber+Damage+in+Human+Diabetic+Neuropathy.">Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy.</a> <em style='font-style: italic'>Diabetes</em>. <b>56</b>, 2148-2154 (2007).</li><li>Mehra, S., Tavakoli, M., Efron, N., Boulton, A. J. M., Augustine, T., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+Confocal+Microscopy+Detects+Early+Nerve+Regeneration+After+Pancreas+Transplantation+in+Patients+with+Type+1+Diabetes.">Corneal Confocal Microscopy Detects Early Nerve Regeneration After Pancreas Transplantation in Patients with Type 1 Diabetes.</a> <em style='font-style: italic'>Diabetes Care</em>. <b>30</b>, 2608-2612 (2007).</li><li>Tavakoli, M., Marshall, A., Pitceathly, R., Fadavi, H., Gow, D., Roberts, M. E., Efron, N., Boulton, A. J. M., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+confocal+microscopy:+A+novel+means+to+detect+nerve+fibre+damage+in+patients+with+impaired+glucose+tolerance+and+idiopathic+small+fibre+neuropathy.">Corneal confocal microscopy: A novel means to detect nerve fibre damage in patients with impaired glucose tolerance and idiopathic small fibre neuropathy.</a> <em style='font-style: italic'>Experimental Neurology</em>. <b>223</b>, 245-250 (2010).</li><li>Tavakoli, M., Marshall, A., Thompson, L., Kenny, M., Waldek, S., Efron, N., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+confocal+microscopy:+A+novel+technique+to+detect+small-fibre+neuropathy+in+patients+with+Fabry+disease.">Corneal confocal microscopy: A novel technique to detect small-fibre neuropathy in patients with Fabry disease.</a> <em style='font-style: italic'>Muscle &#38; Nerve</em>. <b>40</b>, 976-984 (2009).</li></ol>

<p class="jove_content">角膜共聚焦显微镜（CCM）是一种无创的临床技术，可用于检测早期神经损伤小纤维病变和周围神经病变，包括糖尿病，Fabry病和特发性小纤维神经病（ISFN）量化。眼前的这个技术的临床影响，在我们的能力诊断，后续的进展和评估糖尿病的神经病变和其他周围神经病变患者的治疗反应和患者的治疗效果将有一个直接的影响方面的一个巨大的飞跃。 </p>

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<td>HRT III CCM Machine - The Rostock Cornea Module</td>
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<td> Heidelberg Engineering</td>
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<td>CCM image analysis software v0.6 </td>
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<td>University of Manchester</td>
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corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies

<p class="jove_content">周围神经病变的准确定量是很重要的定义处于危险的患者，预期恶化，并评估新的治疗方法。常规方法评估神经功能缺损和电生理和定量感觉测试的量化功能的改变，检测神经病变。然而，最早的损害，出现细小纤维，但这些测试主要是评估大纤维功能障碍，表现出的再生和修复能力有限。只允许直接检查的​​无髓神经纤维的损伤和修复技术，电子显微镜和皮肤打孔活检腓肠神经活检。然而，无论是侵入性的程序和需要长时间的实验程序和相当的专业知识。角膜共焦显微镜是一种非侵入性的临床技术，它提供了角膜神经<em>纤维在</em>体内成像。我们已经证明了早期神经损伤，先于皮肤活检表皮内的神经纤维与神经性的严重程度和修复以下胰腺移植对糖尿病患者分层损失。我们也证明了在特发性小纤维神经病变和法布里病的神经损害。 </p>

Watch this Scientific Journal Video about Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies at JoVE.com

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

<p class="jove_content">角膜共焦显微镜是一种非侵入性的临床技术，可用于量化C纤维损伤与神经性的严重程度增加患者的诊断和分层。</p>

角膜共聚焦显微镜：一种新型的非侵入性技术来量化小纤维病变周围神经病变

The accurate quantification of peripheral neuropathy is important to define at risk patients, anticipate deterioration, and assess new therapies. ...

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