Name: corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies
Uploaded: 2011-01-03T17:30:00
Description: Watch this Scientific Journal Video about Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies at JoVE.com

<p class="jove_content">この作品は、少年糖尿病研究財団国際（助成17-2008-1031）と国立衛生研究所（助成金1R01DK077903 - 01A1）によってサポートされていました。 </p>

<p class="jove_title">はじめに： </p><p class="jove_content">末梢神経障害の正確な定量化は、リスクの高い患者で定義劣化を予測し、新たな治療法を評価することが重要です。従来の方法では、神経学的欠損と電気生理学を評価し、定量的感覚検査は神経障害を検出するための機能変化を定量化する。しかし、初期の被害は小さい繊維になると、まだこれらのテストは主に大規模な繊維の機能障害を評価し、再生と修復?...

<ol>
	<li>Abbott, C. A., Kallinikos, P., Marshall, A., Finnigan, J., Morgan, P., Efron, N., Boulton, A. J. M., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+Confocal+Microscopy:+A+Novel+Non-invasive+Test+to+Diagnose+and+Assess+Progression+of+Human+Diabetic+Neuropathy.">Corneal Confocal Microscopy: A Novel Non-invasive Test to Diagnose and Assess Progression of Human Diabetic Neuropathy.</a> <em style='font-style: italic'>Diabetes Care</em>. <b>33</b>, 1792-1797 (2010).</li><li>Quattrini, C., Tavakoli, M., Jeziorska, M., Kallinikos, P., Tesfaye, S., Marshall, A., Finnigan, J., Boulton, A. J. M., Efron, N., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Surrogate+Markers+of+Small+Fiber+Damage+in+Human+Diabetic+Neuropathy.">Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy.</a> <em style='font-style: italic'>Diabetes</em>. <b>56</b>, 2148-2154 (2007).</li><li>Mehra, S., Tavakoli, M., Efron, N., Boulton, A. J. M., Augustine, T., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+Confocal+Microscopy+Detects+Early+Nerve+Regeneration+After+Pancreas+Transplantation+in+Patients+with+Type+1+Diabetes.">Corneal Confocal Microscopy Detects Early Nerve Regeneration After Pancreas Transplantation in Patients with Type 1 Diabetes.</a> <em style='font-style: italic'>Diabetes Care</em>. <b>30</b>, 2608-2612 (2007).</li><li>Tavakoli, M., Marshall, A., Pitceathly, R., Fadavi, H., Gow, D., Roberts, M. E., Efron, N., Boulton, A. J. M., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+confocal+microscopy:+A+novel+means+to+detect+nerve+fibre+damage+in+patients+with+impaired+glucose+tolerance+and+idiopathic+small+fibre+neuropathy.">Corneal confocal microscopy: A novel means to detect nerve fibre damage in patients with impaired glucose tolerance and idiopathic small fibre neuropathy.</a> <em style='font-style: italic'>Experimental Neurology</em>. <b>223</b>, 245-250 (2010).</li><li>Tavakoli, M., Marshall, A., Thompson, L., Kenny, M., Waldek, S., Efron, N., Malik, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Corneal+confocal+microscopy:+A+novel+technique+to+detect+small-fibre+neuropathy+in+patients+with+Fabry+disease.">Corneal confocal microscopy: A novel technique to detect small-fibre neuropathy in patients with Fabry disease.</a> <em style='font-style: italic'>Muscle &#38; Nerve</em>. <b>40</b>, 976-984 (2009).</li></ol>

<p class="jove_content">角膜共焦点顕微鏡（CCM）は、初期の神経の損傷を検出し、糖尿病、ファブリー病と特発性に細いファイバ神経障害（ISFN）を含む末梢神経障害で小さな繊維病理を定量化するために使用される非侵襲的な臨床技術です。この手法の直接の臨床的影響は、診断、進行を追跡し、糖尿病性神経障害および他の末梢神経障害患者の治療反応を評価し、患者の予後に直接影響を与えるために我々の能力...

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<td>HRT III CCM Machine - The Rostock Cornea Module</td>
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<td> Heidelberg Engineering</td>
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<td>CCM image analysis software v0.6 </td>
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<td>University of Manchester</td>
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corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies

<p class="jove_content">末梢神経障害の正確な定量化は、リスクの高い患者で定義劣化を予測し、新たな治療法を評価することが重要です。従来の方法では、神経学的欠損と電気生理学を評価し、定量的感覚検査は神経障害を検出するための機能変化を定量化する。しかし、初期の被害は小さい繊維になると、まだこれらのテストは主に大規模な繊維の機能障害を評価し、再生と修復を実証するために限られた能力を持っているように見えます。無髄神経線維の損傷と修復の直接検査を可能にする唯一の技術は、電子顕微鏡と皮膚パンチ生検と生検腓腹神経です。しかし、両方は侵襲的な処置であり、長い実験手順とかなりの専門知識を必要とする。角膜共焦点顕微鏡は、角膜神経線維<em>の</em> in vivoイメージングを提供する非侵襲的な臨床技術です。我々は、神経因性重症度と糖尿病患者における修復以下の膵臓移植の層別化と一緒に皮膚生検で表皮内の神経線維の消失に先行する初期の神経の損傷を、実証している。我々はまた、特発性、小さな繊維の神経障害とファブリー病における神経損傷を示している。 </p>

Watch this Scientific Journal Video about Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies at JoVE.com

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

<p class="jove_content">角膜共焦点顕微鏡は、増加する神経因性重症の患者を診断し、層別化するC線維の損傷を定量化するために使用できる非侵襲的な臨床技術です。</p>

角膜共焦点顕微鏡：末梢神経障害で小型ファイバ病理を定量化するための新しい非侵襲的方法

The accurate quantification of peripheral neuropathy is important to define at risk patients, anticipate deterioration, and assess new therapies. ...

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