Name: a novel method for assessing proximal and distal forelimb function in the rat: the irvine, beatties and bresnahan (ibb) forelimb scale
Uploaded: 2010-12-16T16:00:00
Duration: 12 min 46 s
Description: Watch this Scientific Journal Video about A Novel Method for Assessing Proximal and Distal Forelimb Function in the Rat: the Irvine, Beatties and Bresnahan IBB Forelimb Scale at JoVE.com

美国国立卫生研究院批准NS038079（MSB及JCB卡），美国国立卫生研究院批准AG032518（MSB及JCB卡），纽约州CORE 19772（MSB及JCB卡），美国国立卫生研究院NS069537（ARF）和美国国立卫生研究院NS053059（ARF）。

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	<li>Anderson, K. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Targeting+recovery:+priorities+of+the+spinal+cord-injured+population.">Targeting recovery: priorities of the spinal cord-injured population.</a> J Neurotrauma. 21 (10), 1371-1383 (2004).</li><li>Anderson, K. D., Sharp, K. G., Steward, O. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bilateral+cervical+contusion+spinal+cord+injury+in+rats.">Bilateral cervical contusion spinal cord injury in rats.</a> Exp. Neurol. 220 (1), 9-22 (2009).</li><li>Ballermann, M., Metz, G. A., McKenna, J. E., Klassen, F., Whishaw, Q. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+pasta+matrix+reaching+task:+a+simple+test+for+measuring+skilled+reaching+distance,+direction,+and+dexterity+in+rats.">The pasta matrix reaching task: a simple test for measuring skilled reaching distance, direction, and dexterity in rats.</a> J Neurosci Methods. 106, 39-45 (2001).</li><li>Bertelli, J. A., Mira, J. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Behavioral+evaluating+methods+in+the+objective+clinical+assessment+of+motor+function+after+experimental+brachial+plexus+reconstruction+in+the+rat.">Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat.</a> J Neurosci Methods. 46, (1993).</li><li>Gensel, J. C., Tovar, C. A., Hamers, F. P., Deibert, R. J., Beattie, M. S., Bresnahan, J. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Behavioral+and+histological+characterization+of+unilateral+cervical+spinal+cord+contusion+injury+in+rats.">Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats.</a> J Neurotrauma. 23, 36-54 (2006).</li><li>Girgis, J., Merrett, D., Kirkland, S., Metz, G. A., Verge, V., Fouad, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reaching+training+in+rats+with+spinal+cord+injury+promotes+plasticity+and+task+specific+recovery.">Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery.</a> Brain. 130 (PT 11), 2993-3003 (2007).</li><li>Metz, G. A., Whishaw, I. Q. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Skilled+reaching+an+action+pattern:+stability+in+rat+(Rattus+norvegicus)+grasping+movements+as+a+function+of+changing+food+pellet+size.">Skilled reaching an action pattern: stability in rat (Rattus norvegicus) grasping movements as a function of changing food pellet size.</a> Behav Brain Res. 116 (2), 111-122 (2000).</li><li>Montoya, C. P., Campbell-Hope, L. J., Pemberton, K. D., Dunnett, S. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+"staircase+test":+a+measure+of+independent+forelimb+reaching+and+grasping+abilities+in+rats.">The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats.</a> J Neurosci Methods. 36 (2-3), 219-228 (1991).</li><li>Pearse, D. D., Lo, T. P. J. r., Cho, K. S., Lynch, M. P., Garg, M. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Histopathological+and+behavioral+characterization+of+a+novel+cervical+spinal+cord+displacement+contusion+injury+in+the+rat.">Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat.</a> J Neurotrauma. 22 (6), 680-702 (2005).</li><li>Whishaw, I. Q., Pellis, S. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+structure+of+skilled+forelimb+reaching+in+the+rat:+a+proximally+driven+movement+with+a+single+distal+rotatory+component.">The structure of skilled forelimb reaching in the rat: a proximally driven movement with a single distal rotatory component.</a> Behav. Brain Res. 41 (1), 49-59 (1990).</li></ol>

尔湾，Beatties和布雷斯纳汉前肢规模（IBB）是一个10点的顺序量表的前肢恢复进展。伊布分析近端和远端都在两个任务的全谷物件消费前肢使用，球形和环形谷物中的许多功能。吃谷物的动物影片被评价为最常见的前肢行为（包括联合的立场，支持对象，数字移动和抓技术）用于两个形状，然后选择代表这些行为相结合的基础上分配伊布得分前肢复苏的最大金额。评估应该只，一以贯之的大小和形状的谷类;因此，动物不应该吃谷物碎片时取得的。动物必须履行所有的行为，描述了每个点或动物取得的最接近赤字点。 伊布创建评估前肢​​恢复实验诱发颈椎脊髓损伤。在我们的实验室初步研究发现，与其他行为的检测，恢复评估使用伊布得分是敏感，损伤的严重程度。伊布可能不被限制使用颈椎脊髓损伤，但也可能适用于其他形式的中枢和外周神经损伤，影响正确的前肢功能。

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<td>Froot Loops</td>
<td>&nbsp;</td>
<td>Kellogg&#x2019;s</td>
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<td>Doughnut-shaped cereal Available in: India, Australia, Canada, USA, Germany, Middle east and South America. 
Diameter: ~ 81 mm</td>
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<td>Herseys Co.</td>
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<td>Spherical-shaped cereal Available in: USA 
Diameter: ~ 63 mm</td>
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a novel method for assessing proximal and distal forelimb function in the rat: the irvine, beatties and bresnahan (ibb) forelimb scale

颈脊髓损伤（SCI）的几个实验模型最近已开发，以评估损害的后果，这对脊髓水平（ 皮尔斯等人，2005年，Gensel等，2006年，Anderson 等人，2009年） ，大多数人类SCI（杨，2010; www.sci - INFO - pages.com）发生在这里。行为缺陷包括前肢功能丧失因损坏影响降电机和升序感官系统的脑白质，灰质包含段处理前肢的感觉输入和电机输出电路。此外，人类颈椎脊髓损伤患者的一个最关键的是手/手臂功能的恢复（安德森，2004年）。因此，结果评估近端和远端的前肢功能的措施是必要的。虽然有几个不同方面的前肢恢复颈椎脊髓损伤的实验模型（• 杰尔吉斯等。Gensel等 ，2007年，2006年，Ballerman等人 ，2001年，梅斯和Whishaw，2000年，贝尔泰利敏感的行为分析和米拉，1993年，蒙托亚等 ，1991年，Whishaw和Pellis，1990年），很少有技术提供优良的电机控制和数字运动恢复的详细信息。 尔湾，Beatties和前肢规模布雷斯纳汉（IBB），电流测量技术，可以检测包括位在一种自然发生的的行为动作，并不需要广泛的培训或剥夺，增强学习动力的近端和远端的前肢功能的恢复。伊布是通过观察C6脊髓损伤后单方面的恢复，产生和涉及动物吃了两个不同形状大小一致的谷物（球面和圆环）的视频录音。这些影片，然后用评估的共同立场，支持对象，数字移动和抓技术，前肢使用的功能，如。 伊布，前肢像其他行为的任务，显示了复苏的一贯损伤的严重程度是敏感的。此外，伊布规模可以使用，以评估后的恢复其他类型的损伤，影响正常的前肢功能。

Watch this Scientific Journal Video about A Novel Method for Assessing Proximal and Distal Forelimb Function in the Rat: the Irvine, Beatties and Bresnahan IBB Forelimb Scale at JoVE.com

A Novel Method for Assessing Proximal and Distal Forelimb Function in the Rat: the Irvine, Beatties and Bresnahan IBB Forelimb Scale

在这里，我们将描述一种啮齿类动物行为的检测，可以检测在一种自然发生的的行为，包括两位数的动作，并不需要广泛的培训或剥夺，增强学习动力的近端和远端的前肢功能恢复。

一个评估在大鼠近端和远端的前肢功能的新方法：欧文，Beatties和布雷斯纳汉（IBB）前肢规模

Several experimental models of cervical spinal cord injury (SCI) have been developed recently to assess the consequences of damage to this level of the ...

Research

JoVE Journal

Neuroscience

A Novel Method for Assessing Proximal and Distal Forelimb Function in the Rat: the Irvine, Beatties and Bresnahan (IBB) Forelimb Scale

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