Name: combining transcranial magnetic stimulation and fmri to examine the default mode network
Uploaded: 2010-12-28T17:00:00
Description: Watch this Scientific Journal Video about Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network at JoVE.com

1。制备<ol class="lalpha"><li>首先，获得一个基线解剖扫描你的主题。这项工作应在数天前的实际实验。 </li><li>接下来，加载到您的无框架立体定向软件包的扫描。 </li><li>最后，定位和目标刺激坐标。在这种情况下，我们将针对左顶下小叶。 </li></ol> 2。初始扫描<ol class="lalpha"><li>在实验的日子，你的主题将再次开始在MRI机器。 </li><li>首先解剖扫描。 </li><li>接下来，进行三种功?...

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	<li>Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., Shulman, G. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+default+mode+of+brain+function.">A default mode of brain function.</a> Proc. Nat. Acad. Sciences. 98 (2), 676-682 (2001).</li><li>Buckner, R. L., Andrews-Hanna, J. R., Schacter, D. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+brain's+default+network:+anatomy,+function+and+relevance+to+disease.">The brain's default network: anatomy, function and relevance to disease.</a> Ann. N.Y. Acad. Sci. 1124, 1-38 (2008).</li><li>Raichle, M. E., Snyder, A. Z. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+default+mode+of+brain+function:+a+brief+history+of+an+evolving+idea.">A default mode of brain function: a brief history of an evolving idea.</a> Neuroimage. 37 (4), 1083-1090 (2007).</li><li>Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., Wojcik, J., Gabrieli, J. D., Sidman, L. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Hyperactivity+and+hyperconnectivity+of+the+default+network+in+schizophrenia+and+in+first-degreerelatives+of+persons+with+schizophrenia.">Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degreerelatives of persons with schizophrenia.</a> Proc. Nat. Acad. Sciences. 106 (4), 1279-1284 (2009).</li><li>Pomarol-Clotet, E., Salvardor, R., Sarro, S., Gomar, J., Vila, F., Martinez, A., Guerrrero, A., Ortiz-Gil, J., Sans-Sansa, B., Capdevila, A., Cebamanos, J. M., McKenna, P. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Failure+to+deactivate+the+prefrontal+cortex+in+schizophrenia:+dysfunction+of+the+default+mode+network?.">Failure to deactivate the prefrontal cortex in schizophrenia: dysfunction of the default mode network?.</a> Psychol Med. 38 (8), 1185-1193 (2008).</li><li>Garrity, A. G., Pearlson, G. D., McKiernan, K., Lloyd, D., Kiehl, K. A., Calhoun, V. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Aberrant+"default+mode"+functional+connectivity+in+schizophrenia.">Aberrant "default mode" functional connectivity in schizophrenia.</a> American Journal of Psychiatry. 164, 450-457 (2007).</li><li>Kennedy, D. P., Redcay, E., Courchesne, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Failing+to+deactivate:+Resting+functional+abnormalities+in+autism.">Failing to deactivate: Resting functional abnormalities in autism.</a> Proc. Nat. Acad. Sciences. 103 (21), 8275-8280 (2007).</li><li>c Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., Mintun, M. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Molecular,+structural,+and+functional+characterizations+of+Alzheimer's+disease:+evidence+for+a+relationship+between+default+activity,+amyloid,+and+memory.">Molecular, structural, and functional characterizations of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory.</a> Journal of Neuroscience. 34, 7709-7717 (2005).</li><li>Pascual-Leone, A., Davey, M., Wassermann, E. M., Rothwell, J., Puri, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Handbook of Transcranial Magnetic Stimulation. , (2002).</li></ol>

<p class="jove_content"当进行脱机TMS / MRI的实验，可以说是最重要的考虑涉及迅速和轻松刺激的部位的MRI湾过渡。因此，这将是值得重新考虑的上述建议，以帮助在这个过渡想法几个。第一：使用一台便携式的TMS的机器设置在一个尽可能接近的核磁共振湾位置。二：规避任何自动编入MRI设备的待机或等效机制。三：确保提高平台，并加载之前完成主体TMS的刺激。最后，四：不要试图单独做这一切。始终至少有两个活跃?...

<ul><li>磁共振成像配备功​​能磁共振成像（图为视频是飞利浦） </li><li> TMS的设备能够重复刺激（视频图是一个Magstim） </li><li>无框式立体定向设备（图为视频是Brainsight） </li><li>耳塞</li><li>在刺激为主题的主席</li><li>回到投影屏幕或MRI兼容护目镜</li><li>空白刺激屏幕</li></ul>

combining transcranial magnetic stimulation and fmri to examine the default mode network

默认模式网络是一个组的大脑区域是活跃的，当一个人是不是集中在外面的世界，大脑在“ 清醒休息。”1,2,3它被认为是默认模式网络对应的自我指涉或“内部心理状态。”2,3 据推测，在人类中，在默认模式下的网络活动是与某些病症（例如相关，超激活已与精神分裂症4,5,6和7，而网络的低激活了自闭症谱系障碍被认为与阿尔茨海默氏症和其他神经退行性疾病8）。因此，这个网络的非侵入性的调制可能代表了一种潜在的治疗干预与网络激活异常的神经和精神病的病状。一个可能的工具，对这种调制是经颅磁刺激：一种非侵入性neurostimulatory和neuromodulatory技术，可以短暂或持久的应用本地化的磁场脉冲通过调节大脑皮层兴奋性（增加或减少 ） 9。 为了探索默认模式网络的倾向，对和宽容的调制，我们将结合TMS（左下顶叶）功能磁共振成像（fMRI）。通过这篇文章，我们会研究的协议，并考虑必要的成功结合这两种神经科学的工具。

Watch this Scientific Journal Video about Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network at JoVE.com

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

在这篇文章中，我们研究的方法和注意事项有关的TMS和功能磁共振成像相结合，研究脑刺激的影响，默认的网络。

结合经颅磁刺激和功能磁共振成像检查默认模式网络

The default mode network is a group of brain regions that are active when an individual is not focused on the outside world and the brain is at "wakeful ...

Research

JoVE Journal

Neuroscience

A Novel Approach for Documenting Phosphenes Induced by Transcranial Magnetic Stimulation

一个新颖的方法记录经颅磁刺激诱发幻视

Stimulation of the human visual cortex produces a transient perception of light, known as a phosphene. Phosphenes are induced by invasive electrical ...

科研

神经科学

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

经颅直接电流刺激电极定位和蒙太奇

Transcranial direct current stimulation (tDCS) is a technique that has been intensively investigated in the past decade as this method offers a ...

Extracting Visual Evoked Potentials from EEG Data Recorded During fMRI-guided Transcranial Magnetic Stimulation

提取脑电数据视觉诱发电位记录在功能磁共振成像引导下经颅磁刺激

Transcranial Magnetic Stimulation (TMS) is an effective method for establishing a causal link between a cortical area and cognitive/neurophysiological ...

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

磁共振波谱的用途，用于对初级运动皮层新陈代谢双半球经颅电刺激效果的测量工具一

Transcranial direct current stimulation (tDCS) is a neuromodulation technique that has been increasingly used over the past decade in the treatment of ...

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

经颅磁刺激在线联合方法对经颅交流电刺激对原发性运动皮层的影响

Transcranial Alternating Current Stimulation (tACS) is a neuromodulatory technique able to act through sinusoidal electrical waveforms in a specific ...

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

在线经颅磁刺激测量与反应抑制相关的皮质生理

We describe the development of a reproducible, child-friendly motor response inhibition task suitable for online Transcranial Magnetic Stimulation (TMS) ...

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

侧前额叶皮质联合经颅磁刺激与脑电图的研究

Transcranial magnetic stimulation (TMS) is a non-invasive method that produces neural excitation in the cortex by means of brief, time-varying magnetic ...

Bilateral Assessment of the Corticospinal Pathways of the Ankle Muscles Using Navigated Transcranial Magnetic Stimulation

导航经颅磁刺激踝关节脊椎通路的双边评价

Distal leg muscles receive neural input from motor cortical areas via the corticospinal tract, which is one of the main motor descending pathway in humans ...

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

利用颅内磁刺激测量和操纵人体运动系统中功能特定的神经通路

Understanding interactions between brain areas is important for the study of goal-directed behavior. Functional neuroimaging of brain connectivity has ...

Employing Transcranial Magnetic Stimulation in a Resource Limited Environment to Establish Brain-Behavior Relationships

在资源有限的环境中采用经颅磁刺激来建立大脑行为关系

Neuroimaging is typically perceived as a resource demanding discipline. While this is the case in certain circumstances, institutions with limited ...