Name: peptides from phage display library modulate gene expression in mesenchymal cells and potentiate osteogenesis in unicortical bone defects
Uploaded: 2010-12-10T17:00:00
Duration: 7 min 53 s
Description: Watch this Scientific Journal Video about Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects at JoVE.com

Institutos Nacionales de Salud, AR53579, Osteogénesis: Potenciación de péptidos Tropic ósea Institutos Nacionales de Salud, AR056422, efecto anabólico de los péptidos osteogénica Institutos Nacionales de Salud, T32 AR050960, Reparación de Tejidos Musculoesqueléticos y Regeneración DOD, PC051219 nucleolina: A Novel mediador del cáncer de próstata y adhesión de las células endoteliales de la médula ósea Departamento de Defensa, PC061508, el cáncer de próstata metástasis en los huesos por células de médula mediadores de adhesión

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La producción de este video fue patrocinado por New England Biolabs, Inc, que produce algunos de los reactivos utilizados en este artículo.

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peptides from phage display library modulate gene expression in mesenchymal cells and potentiate osteogenesis in unicortical bone defects

Dos péptidos sintéticos novedosos acelerar la formación de hueso y se puede entregar con una matriz de colágeno. El objetivo de este estudio fue investigar los efectos de la reparación ósea en un modelo de defecto unicortical. Tratamiento de las células mesenquimales producido un aumento de la actividad de la fosfatasa alcalina, mostró la formación de nódulos en las células, y el aumento de la expresión de genes de Runx2, osterix, sialoproteína ósea y osteocalcina. Una esponja empapada con la reparación del colágeno péptido promovido de defectos óseos, mientras que el control era menos eficaz. Los resultados de este estudio demostraron que las células mesenquimales tratados con el péptido in vitro se diferencian hacia la osteogénesis y, que los péptidos entrega en vivo con una esponja de colágeno promover la reparación de defectos unicortical.

Watch this Scientific Journal Video about Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects at JoVE.com

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Una biblioteca de fagos se utilizó para identificar las secuencias de péptidos de que el hueso blanco. El objetivo fue investigar el efecto de estos péptidos en la diferenciación de células mesenquimales y para determinar su efecto sobre la regeneración ósea.

Péptidos de la Biblioteca de Phage Display modular la expresión génica en las células mesenquimales y potenciar la osteogénesis en defectos óseos unicorticales

Two novel synthetic peptides accelerate bone formation and can be delivered using a collagen matrix. The aim of this study was to investigate the effects ...

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