Name: a protocol for comprehensive assessment of bulbar dysfunction in amyotrophic lateral sclerosis (als)
Uploaded: 2011-02-21T18:00:00
Duration: 12 min 43 s
Description: Watch this Scientific Journal Video about A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS at JoVE.com

This work has been supported by the National Institute of Health, National Institute on Deafness and Other Communication Disorders, Grant R01DCO09890-02, Canadian Foundation for Innovation (CFI-LOF #15704), and Connaught Foundation, University of Toronto. The authors would like to thank Cynthia Didion, Mili Kuruvilla, Krista Rudy, and Lori Synhorst for assistance with data collection and analysis; and Cara Ullman for creating video clips.
Animations were made by Blue Tree Publishing (<a href="http://www.bluetreepublishing.com/">http://www.bluetreepublishing.com/</a>)
The SPA and SMASH software is Matlab based and can be obtained by contacting Jordan Green at jgreen4@unl.edu. 
Visit our labs:
Bulbar Function Laboratory (Sunnybrook Health Sciences Centre in Toronto, Canada): 
<a href="http://www.sunnybrook.ca/research/?page=sri_groups_bulb_home">http://www.sunnybrook.ca/research/?page=sri_groups_bulb_home</a> 
Speech Production Laboratory (University Nebraska Lincoln): <a href="http://spl.unl.edu">http://spl.unl.edu</a>

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ब्याज की कोई संघर्ष की घोषणा की.

यहाँ हम कंदाकार के मूल्यांकन (भाषण) ALS में शिथिलता के लिए एक व्यापक प्रोटोकॉल का प्रदर्शन किया. इस प्रोटोकॉल से प्राप्त डेटा के लिए कैसे ए एल एस भाषण उत्पादन को प्रभावित करता है की एक गहरी समझ हासिल करने के लिए उपयोग किया जाता है. इन आंकड़ों को भी रोग प्रगति के सबसे संवेदनशील उपायों की पहचान के लिए उपयोग किया जाता है. हालांकि इस प्रोटोकॉल वर्तमान में अनुसंधान के लिए नियोजित किया जा रहा है, इस शोध से निष्कर्ष करने के लिए और अधिक लागत प्रभावी और चिकित्सकीय संभव दृष्टिकोण विकसित कंदाकार भागीदारी यों उपयोग किया जाएगा.

<ul><li> उपकरण / सॉफ्टवेयर </li><li> Phonatory Aerodynamic प्रणाली (पीए), KayPENTAX, लिंकन पार्क, न्यू जर्सी, संयुक्त राज्य अमरीका </li><li> कॉम्पैक्ट फ़्लैश रिकॉर्डर (उदाहरण के लिए, PMD660) </li><li> व्यावसायिक गुणवत्ता माइक्रोफोन, </li><li> SPL मीटर, Extech उपकरण </li><li> MDVP, KAYPentax </li><li> Nasometer, मॉडल 6400, KAYPentax </li><li> ईगल डिजिटल प्रणाली, मोशन विश्लेषण कॉर्प </li><li> लहर, उत्तरी डिजिटल इंक, कनाडा </li></ul>

a protocol for comprehensive assessment of bulbar dysfunction in amyotrophic lateral sclerosis (als)

Improved methods for assessing bulbar impairment are necessary for expediting diagnosis of bulbar dysfunction in ALS, for predicting disease progression across speech subsystems, and for addressing the critical need for sensitive outcome measures for ongoing experimental treatment trials. To address this need, we are obtaining longitudinal profiles of bulbar impairment in 100 individuals based on a comprehensive instrumentation-based assessment that yield objective measures. Using instrumental approaches to quantify speech-related behaviors is very important in a field that has primarily relied on subjective, auditory-perceptual forms of speech assessment1. Our assessment protocol measures performance across all of the speech subsystems, which include respiratory, phonatory (laryngeal), resonatory (velopharyngeal), and articulatory. The articulatory subsystem is divided into the facial components (jaw and lip), and the tongue. Prior research has suggested that each speech subsystem responds differently to neurological diseases such as ALS. The current protocol is designed to test the performance of each speech subsystem as independently from other subsystems as possible. The speech subsystems are evaluated in the context of more global changes to speech performance. These speech system level variables include speaking rate and intelligibility of speech.
The protocol requires specialized instrumentation, and commercial and custom software. The respiratory, phonatory, and resonatory subsystems are evaluated using pressure-flow (aerodynamic) and acoustic methods. The articulatory subsystem is assessed using 3D motion tracking techniques. The objective measures that are used to quantify bulbar impairment have been well established in the speech literature and show sensitivity to changes in bulbar function with disease progression. The result of the assessment is a comprehensive, across-subsystem performance profile for each participant. The profile, when compared to the same measures obtained from healthy controls, is used for diagnostic purposes. Currently, we are testing the sensitivity and specificity of these measures for diagnosis of ALS and for predicting the rate of disease progression. In the long term, the more refined endophenotype of bulbar ALS derived from this work is expected to strengthen future efforts to identify the genetic loci of ALS and improve diagnostic and treatment specificity of the disease as a whole. The objective assessment that is demonstrated in this video may be used to assess a broad range of speech motor impairments, including those related to stroke, traumatic brain injury, multiple sclerosis, and Parkinson disease.

Watch this Scientific Journal Video about A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS at JoVE.com

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

शारीरिक तंत्र का उद्देश्य आकलन है कि भाषण का समर्थन रोग और ए एल एस के साथ लोगों में शुरुआत प्रगति की निगरानी और नैदानिक ​​परीक्षणों में उपचार के प्रभाव यों की जरूरत है. इस वीडियो में, हम नैदानिक ​​आबादी में भाषण मोटर प्रदर्शन बढ़ाता के लिए एक व्यापक, इंस्ट्रूमेंटेशन आधारित प्रोटोकॉल मौजूद है.

Amyotrophic पार्श्व स्केलेरोसिस में कंदाकार शिथिलता के व्यापक मूल्यांकन (ए एल एस) के लिए एक प्रोटोकॉल

Improved methods for assessing bulbar impairment are necessary for expediting diagnosis of bulbar dysfunction in ALS, for predicting disease progression ...

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A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)

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