Name: brain imaging investigation of the memory-enhancing effect of emotion
Uploaded: 2011-05-04T13:00:00
Description: Watch this Scientific Journal Video about Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion at JoVE.com

FD wurde von einem Young Investigator Award der National Alliance for Research on Schizophrenia and Depression und eine KPRF Award der Canadian Psychiatric Research Foundation unterstützt.

1. Experimental Design, methodischen Fragen &amp; Stimuli Die SMP bestehen aus zwei Aufgaben, eine Codierung Aufgabe und Retrieval-Aufgabe, und die Aufnahme der Gehirnaktivität kann während der Kodierung Aufgabe oder während der beiden Ver-und Retrieval-Aufgaben (siehe Abbildung 1 für ein Diagramm, das Design des SMP) auftreten. <img src="/files/ftp_upload/2433/2433fig1.jpg" alt="Abbildung 1" /> Abbildung 1. Allgemeine Schema der SMP-Desig...

<ol>
	<li>Bradley, M. M., Greenwald, M. K., Petry, M. C., Lang, P. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Remembering+pictures:+pleasure+and+arousal+in+memory.">Remembering pictures: pleasure and arousal in memory.</a> J Exp Psychol Learn Mem Cogn. 18, 379-390 (1992).</li><li>Christianson, S. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Emotional+stress+and+eyewitness+memory:+a+critical+review.">Emotional stress and eyewitness memory: a critical review.</a> Psychol Bull. 112, 284-309 (1992).</li><li>Paller, K. A., Wagner, A. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Observing+the+transformation+of+experience+into+memory.">Observing the transformation of experience into memory.</a> Trends Cogn Sci. 6, 93-102 (2002).</li><li>Dolcos, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> The Impact of Emotion on Memory: Evidence from Brain Imaging Studies. , (2009).</li><li>Dolcos, F., Denkova, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Neural+correlates+of+encoding+emotional+memories:+a+review+of+functional+neuroimaging+evidence.">Neural correlates of encoding emotional memories: a review of functional neuroimaging evidence.</a> Cell Science Reviews. 5, 78-122 (2008).</li><li>Dolcos, F., LaBar, K. S., Cabeza, R., Uttl, B., Ohta, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+memory-enhancing+effect+of+emotion:+Functional+neuroimaging+evidence.">The memory-enhancing effect of emotion: Functional neuroimaging evidence.</a> Memory and Emotion: Interdisciplinary Perspectives. , 107-134 (2006).</li><li>LaBar, K. S., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cognitive+neuroscience+of+emotional+memory.">Cognitive neuroscience of emotional memory.</a> Nat Rev Neurosci. 7, 54-64 (2006).</li><li>Dolcos, F., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Event-related+potentials+of+emotional+memory:+encoding+pleasant,+unpleasant,+and+neutral+pictures.">Event-related potentials of emotional memory: encoding pleasant, unpleasant, and neutral pictures.</a> Cogn Affect Behav Neurosci. 2, 252-263 (2002).</li><li>Dolcos, F., Graham, R., LaBar, K. S., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Coactiviation+of+the+amygdala+and+hippocampus+predicts+better+recall+for+emotional+than+for+neutral+pictures.">Coactiviation of the amygdala and hippocampus predicts better recall for emotional than for neutral pictures.</a> Brain &#38; Cognition. 51, 221-223 (2003).</li><li>Dolcos, F., LaBar, K. S., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dissociable+effects+of+arousal+and+valence+on+prefrontal+activity+indexing+emotional+evaluation+and+subsequent+memory:+an+event-related+fMRI+study.">Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study.</a> Neuroimage. 23, 64-74 (2004).</li><li>Dolcos, F., LaBar, K. S., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Interaction+between+the+amygdala+and+the+medial+temporal+lobe+memory+system+predicts+better+memory+for+emotional+events.">Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events.</a> Neuron. 42, 855-863 (2004).</li><li>Dolcos, F., LaBar, K. S., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Remembering+one+year+later:+role+of+the+amygdala+and+the+medial+temporal+lobe+memory+system+in+retrieving+emotional+memories.">Remembering one year later: role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories.</a> Proc Natl Acad Sci U S A. 102, 2626-2631 (2005).</li><li>Ritchey, M., Dolcos, F., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Role+of+amygdala+connectivity+in+the+persistence+of+emotional+memories+over+time:+an+event-related+FMRI+investigation.">Role of amygdala connectivity in the persistence of emotional memories over time: an event-related FMRI investigation.</a> Cereb Cortex. 18, 2494-2504 (2008).</li><li>Jacques, S. t., Dolcos, P. L., Cabeza, F., R, . <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effects+of+aging+on+functional+connectivity+of+the+amygdala+for+subsequent+memory+of+negative+pictures:+a+network+analysis+of+functional+magnetic+resonance+imaging+data.">Effects of aging on functional connectivity of the amygdala for subsequent memory of negative pictures: a network analysis of functional magnetic resonance imaging data.</a> Psychol Sci. 20, 74-84 (2009).</li><li>Jacques, S. t., Dolcos, P., Cabeza, F., R, . <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effects+of+aging+on+functional+connectivity+of+the+amygdala+during+negative+evaluation:+a+network+analysis+of+fMRI+data.">Effects of aging on functional connectivity of the amygdala during negative evaluation: a network analysis of fMRI data.</a> Neurobiol Aging. 31, 315-327 (2010).</li><li>Hayes, J. P., LaBar, K. S., McCarthy, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reduced+hippocampal+and+amygdala+activity+predicts+memory+distrotions+for+trauma+reminders+in+combat-related+PTSD.">Reduced hippocampal and amygdala activity predicts memory distrotions for trauma reminders in combat-related PTSD.</a> J Psychiatr Res. , (2011).</li><li>Ritchey, M., Dolcos, F., Eddington, K. M., Strauman, T. J., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Neural+correlates+of+emotional+processing+in+depression:+Changes+with+cognitive+behavioral+therapy+and+predictors+of+treatment+response.">Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response.</a> Journal of Psychiatric Research. , (2010).</li><li>Kleinsmith, L. J., Kaplan, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Paired-associate+learning+as+a+function+of+arousal+and+interpolated+interval.">Paired-associate learning as a function of arousal and interpolated interval.</a> J Exp Psychol. 65, 190-193 (1963).</li><li>Kensinger, E. A., Schacter, D. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Amygdala+activity+is+associated+with+the+successful+encoding+of+item,+but+not+source,+information+for+positive+and+negative+stimuli.">Amygdala activity is associated with the successful encoding of item, but not source, information for positive and negative stimuli.</a> J Neurosci. 26, 2564-2570 (2006).</li><li>Kensinger, E. A., Corkin, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Two+routes+to+emotional+memory:+distinct+neural+processes+for+valence+and+arousal.">Two routes to emotional memory: distinct neural processes for valence and arousal.</a> Proc Natl Acad Sci U S A. 101, 3310-3315 (2004).</li><li>Kensinger, E. A., Garoff-Eaton, R. J., Schacter, D. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Memory+for+specific+visual+details+can+be+enhanced+by+negative+arousing+content.">Memory for specific visual details can be enhanced by negative arousing content.</a> Journal of Memory and Language. 54, 99-112 (2006).</li><li>Bradley, M. M., Cuthbert, B. N., Lang, P. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Picture+media+and+emotion:+effects+of+a+sustained+affective+context.">Picture media and emotion: effects of a sustained affective context.</a> Psychophysiology. 33, 662-670 (1996).</li><li>Lang, P. J., Bradley, M. M., Cuthbert, B. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Technical+Report+A-8.">Technical Report A-8.</a> International affective picture system (IAPS): Affective ratings of pictures and instruction manual. , (2008).</li><li>Lang, P. J., Bradley, M. M., Cuthbert, B. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Technical+report+C-1.">Technical report C-1.</a> Affective norms for English workds (ANEW): Stimuli, instruction manual and affective ratings. , (2008).</li><li>Bradley, M. M., Lang, P. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Measuring+emotion:+the+Self-Assessment+Manikin+and+the+Semantic+Differential.">Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.</a> J Behav Ther Exp Psychiatry. 25, 49-59 (1994).</li><li>Kensinger, E. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Remembering+emotional+experiences:+the+contribution+of+valence+and+arousal.">Remembering emotional experiences: the contribution of valence and arousal.</a> Rev Neurosci. 15, 241-251 (2004).</li><li>Hamann, S. B., Ely, T. D., Grafton, S. T., Kilts, C. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Amygdala+activity+related+to+enhanced+memory+for+pleasant+and+aversive+stimuli.">Amygdala activity related to enhanced memory for pleasant and aversive stimuli.</a> Nat Neurosci. 2, 289-293 (1999).</li><li>Watson, D., Clark, L. A., Tellegen, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Development+and+validation+of+brief+measures+of+positive+and+negative+affect:+the+PANAS+scales.">Development and validation of brief measures of positive and negative affect: the PANAS scales.</a> J Pers Soc Psychol. 54, 1063-1070 (1988).</li><li>Spielberger, C. D., Gorsuch, R. L., Lushene, R. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Manual for the State-Trait Anxiety Inventory. , (1970).</li><li>Voyvodic, J. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Real-Time+fMRI+Paradigm+Control,+Physiology,+and+Behavior+Combined+with+Near+Real-Time+Statistical+Analysis.">Real-Time fMRI Paradigm Control, Physiology, and Behavior Combined with Near Real-Time Statistical Analysis.</a> NeuroImage. 10, 91-106 (1999).</li><li>Tulving, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Memory+and+consciousness.">Memory and consciousness.</a> Canadian Psychology. 26, 1-12 (1985).</li><li>Eldridge, L. L., Knowlton, B. J., Furmanski, C. S., Bookheimer, S. Y., Engel, S. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Remembering+episodes:+a+selective+role+for+the+hippocampus+during+retrieval.">Remembering episodes: a selective role for the hippocampus during retrieval.</a> Nat Neurosci. 3, 1149-1152 (2000).</li><li>Kirwan, C. B., Jones, C. K., Miller, M. I., Stark, C. E. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=High-resolution+fMRI+investigation+of+the+medial+temporal+lobe.">High-resolution fMRI investigation of the medial temporal lobe.</a> Human Brain Mapping. 28, 959-966 (2007).</li><li>Preston, A. R., Bornstein, A. M., Hutchinson, J. B., Gaare, M. E., Glover, G. H., Wagner, A. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=High-resolution+fMRI+of+Content-sensitive+Subsequent+Memory+Responses+in+Human+Medial+Temporal+Lobe.">High-resolution fMRI of Content-sensitive Subsequent Memory Responses in Human Medial Temporal Lobe.</a> Journal of Cognitive Neuroscience. 22, 156-173 (2010).</li><li>Robinson, S., Pripfl, J., Bauer, H., Moser, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+impact+of+EPI+voxel+size+on+SNR+and+BOLD+sensitivity+in+the+anterior+medio-temporal+lobe:+a+comparative+group+study+of+deactivation+of+the+Default+Mode.">The impact of EPI voxel size on SNR and BOLD sensitivity in the anterior medio-temporal lobe: a comparative group study of deactivation of the Default Mode.</a> Magnetic Resonance Materials in Physics, Biology and Medicine. 21, 279-290 (2008).</li><li>Daselaar, S. M., Fleck, M. S., Cabeza, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Triple+Dissociation+in+the+Medial+Temporal+Lobes:+Recollection,+Familiarity,+and+Novelty.">Triple Dissociation in the Medial Temporal Lobes: Recollection, Familiarity, and Novelty.</a> Journal of Neurophysiology. 96, 1902-1911 (2006).</li><li>McGaugh, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Memory--a+century+of+consolidation.">Memory--a century of consolidation.</a> Science. 287, 248-251 (2000).</li><li>McGaugh, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+amygdala+modulates+the+consolidation+of+memories+of+emotionally+arousing+experiences.">The amygdala modulates the consolidation of memories of emotionally arousing experiences.</a> Annu Rev Neurosci. 27, 1-28 (2004).</li></ol>

Diese experimentelle Protokoll ermöglicht Untersuchung der neuronalen Korrelate des Memory-Effekt der Emotion, durch die gezielte Trennung der Speicher-bezogene Aktivität des Gehirns, die anfällig für Modulation von Emotionen aus der Tätigkeit in Hirnregionen anfällig für Emotionen Modulation während general / Wahrnehmungsverarbeitung ist. Dieses Design wurde in Erweiterung der Kenntnisse über die neuronalen Mechanismen, die die Auswirkungen von Emotionen auf das Gedächtnis instrumental, und angesichts seiner ...

brain imaging investigation of the memory-enhancing effect of emotion

Emotionale Ereignisse neigen dazu, besser als nicht-emotionalen Ereignissen 1,2 in Erinnerung bleiben. Ein Ziel der kognitiven und affektiven Neurowissenschaft ist es, die neuronalen Mechanismen dieser Effekt der Emotion auf das Gedächtnis zu verstehen. Eine Methode, die sich als besonders einflussreich wurde in der Untersuchung der Speicher-steigernde Wirkung von Emotionen ist die so genannte nachträgliche Erinnerung Paradigma (SMP). Diese Methode wurde ursprünglich benutzt, um die neuronalen Korrelate von nicht-emotionalen Erinnerungen 3 zu untersuchen, und in jüngerer Zeit die wir und andere auch angewendet erfolgreich zum Studium der emotionalen Gedächtnis (reviewed in 4, 5-7). Hier beschreiben wir ein Protokoll, das ermöglicht Untersuchung der neuronalen Korrelate des Memory-Effekt der Emotion mit der SMP in Verbindung mit ereignisbezogene funktionelle Kernspintomographie (fMRI). Ein wichtiges Merkmal des SMP ist eine Trennung der Hirnaktivität spezifisch mit Speicher von mehr allgemeine Tätigkeit mit der Wahrnehmung assoziiert werden können. Darüber hinaus im Rahmen der Untersuchung der Auswirkungen von emotionalen Reizen, ermöglicht SMP Identifikation von Hirnregionen, deren Aktivität anfälliger für emotionale Modulation der sowohl allgemeine / Wahrnehmungs-und Speicher-spezifische Verarbeitung. Dieses Protokoll kann bei gesunden Probanden 8-15 verwendet werden, sowie in klinischen Patienten, wo es Veränderungen in der neuronalen Korrelate von Emotionen Wahrnehmung und Vorurteile in Erinnerung emotionale Ereignisse, wie sie unter Depressionen leiden und posttraumatischer Belastungsstörung (PTBS ) 16, 17.

Watch this Scientific Journal Video about Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion at JoVE.com

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Wir präsentieren ein Protokoll, das die funktionelle Magnetresonanztomographie nutzt, um die neuronalen Korrelate des Memory-Effekt der Emotion zu untersuchen. Dieses Protokoll ermöglicht die Identifizierung der Hirnaktivität speziell für Speicher-bezogene Verarbeitung, im Gegensatz zu allgemeinen Wahrnehmungsverarbeitung verbunden und können mit gesunden und klinischen Populationen verwendet werden.

Brain Imaging Untersuchung der Memory-Effekt der Emotion

Emotional events tend to be better remembered than non-emotional events1,2. One goal of cognitive and affective neuroscientists is 
to understand the ...

Research

JoVE Journal

Neuroscience

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Brain Imaging Untersuchung der neuronalen Korrelate von Observing virtuellen sozialen Interaktionen

The ability to gauge social interactions is crucial in the assessment of others&#x2019; intentions. Factors such as facial expressions and body language ...

Forschung

Neurowissenschaften

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Brain Imaging Untersuchung der neuronalen Korrelate der emotionalen Autobiographische Erinnerung

Recollection of emotional autobiographical memories (AMs) is important to healthy cognitive and affective functioning 1 - remembering positive AMs is ...

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Untersuchung der neuronalen Korrelate der Emotionsregulation

The ability to control/regulate emotions is an important coping mechanism in the face of emotionally stressful situations. Although significant progress ...

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Brain Imaging Untersuchung der beeinträchtigende Wirkung von Emotion auf Kognition

Emotions can impact cognition by exerting both enhancing (e.g., better memory for emotional events) and impairing (e.g., increased emotional ...

Enabling High Grayscale Resolution Displays and Accurate Response Time Measurements on Conventional Computers

Enabling High Graustufen auflösende Displays und präzise Antwort Zeitmessungen auf herkömmlichen Computern

Display systems based on conventional computer graphics cards are capable of generating images with 8-bit gray level resolution. However, most experiments ...

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Live-Imaging der Mitose in der Entwicklung von embryonalen Maus-Cortex

Although of short duration, mitosis is a complex and dynamic multi-step process fundamental for development of organs including the brain. In the ...

Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain

Live-Imaging des Ependymale Cilia in der Seitenventrikel des Maus-Gehirn-

Multiciliated ependymal cells line the ventricles in the adult brain. Abnormal function or structure of ependymal cilia is associated with various ...

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Groß angelegte dreidimensionale Bildgebung der zelluläre Organisation in der Maus Neocortex

The mammalian neocortex is composed of many types of excitatory and inhibitory neurons, each with specific electrophysiological and biochemical ...

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging im Hippocampus von Ratten mit leichter traumatischer Hirnverletzung

Mild traumatic brain injury (mTBI) is the most common type of acquired brain injury. Since patients with traumatic brain injury show a tremendous ...

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Untersuchung der räumlichen Interaktion zwischen Astrozyten und Neuronen in geräumten Gehirnen

Combining viral vector transduction and tissue clearing using the CLARITY method makes it possible to simultaneously investigate several types of brain ...