Name: microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects
Uploaded: 2011-05-11T13:00:00
Description: Watch this Scientific Journal Video about Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects at JoVE.com

Deze studie werd ondersteund door het &#39;Medisch Wetenschappelijke Fonds van de burgemeester van de stad Wenen&#39; en Ethicon Biochirurgie, Inc New Jersey, USA. De auteurs uiten hun dank aan professor Heber Ferraz-Leite, directeur van de &quot;Europese workshop over microchirurgie en Cerebrale revascularisatie &#39;aan de Medische Universiteit van Wenen, Oostenrijk, voor zijn waardevolle microchirurgische onderwijs.

1. Positionering en de voorbereiding van het dier De experimenten werden goedgekeurd door de bevoegde lokale ethische commissie en uitgevoerd volgens de richtlijnen Felasa. <ol><li> Start algehele anesthesie van de vrouwelijke New Zealand White rabbit (+2,5 tot 3,5 kg) met een intramusculaire injectie van Ketamin (30mg/kg) en xylazine (6mg/kg) en ga verder na mechanische intubatie (buisdiameter 4mm, lengte 18mm) met gas anesthesie ( isofluraan) onder ECG monitoring. Voer pijn monitoring vi...

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De auteurs adviseren attent de volgende kritische chirurgische belangrijke stappen om goede resultaten en patent aneurysma&#39;s te bereiken: <ol><li> Zorgvuldige dissectie van een lange segment van de linker CCA voor een gemakkelijke anastomose zonder vernietiging van zenuwen en kleine vaartuigen. </li><li> Zorgvuldige verwijdering van de zeer trombogene periadventitial vezelig weefsel vóór de oprichting van de anastomose. </li><li> Oprichting van een tensionless anastomose. </li><li> Minder hechtingen: De voorge...

<table border="1"><tbody><tr><th> Naam van het serum </th><th> Vennootschap </th><th> Catalogus nummer </th><th> Reacties </th></tr><tr><td> Vicryl4-0 polyfilament restaureerbaar hechtingen </td><td> Ethicon Inc </td><td> J386H </td><td></td></tr><tr><td> Ethilon 10-0 monofilament niet resorbeerbare hechtingen </td><td> Ethicon Inc </td><td> 2814 </td><td> taper punt naald </td></tr><tr><td> Evicel Bioglue </td><td> Ethicon Biochirurgie Inc </td><td> 3901 </td><td></td></tr><tr><td> Fentanyl dermale pleister 12,5 microgram / uur </td><td></td><td></td><td> Elke genericon </td></tr><tr><td> Heparine </td><td></td><td></td><td> Elke genericon </td></tr><tr><td> 0,9% Saline </td><td></td><td></td><td> Elke genericon </td></tr><tr><td> 4% Papaverin HCl </td><td></td><td></td><td> Elke genericon </td></tr><tr><td> Neomycine sulfaat 5 mg / ml </td><td></td><td></td><td> Elke genericon </td></tr><tr><td> Ketamin 50mg/ml </td><td></td><td></td><td> Elke genericon </td></tr><tr><td> Xylazine 20mg/ml </td><td></td><td></td><td> Elke genericon </td></tr></tbody></table>

microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects

Voor gescheurd menselijke cerebrale aneurysma endovasculaire embolisatie is uitgegroeid tot een gelijkwaardig alternatief voor aneurysma knippen. 1 echter grote klinische studies hebben aangetoond teleurstellende resultaten op lange termijn met een onaanvaardbaar hoge tarieven van aneurysma rekanalisatie en vertraagde aneurysma scheuren. 2 Om deze problemen te overwinnen, dierexperimentele studies zijn cruciaal voor de ontwikkeling van betere endovasculaire apparaten. 3-5 Verschillende diermodellen bij ratten, konijnen, honden en varkens zijn beschikbaar. 6-8 Vergelijking van de verschillende diermodellen toonde de superioriteit van het konijn model met betrekking tot de hemodynamica en de vergelijkbaarheid van het stollingssysteem en kosteneffectiviteit. 9-11 De veneuze zakje arteriële splitsing model in konijnen wordt gevormd door een veneuze zakje gehecht in een kunstmatig gecreëerd waar splitsing van beide gemeenschappelijke halsslagaders (CCA). Het belangrijkste voordeel van dit model zijn waar bifurcational hemodynamiek. 12 De belangrijkste nadelen zijn de tot nu toe hoge microchirurgische technische eisen en de hoge morbiditeit en mortaliteit tot 50%. 13 Deze beperkingen hebben geleid tot minder frequent gebruik van dit aneurysma model in de recente jaar. Deze tekortkomingen kunnen worden verholpen met een verbeterde chirurgische procedures en gewijzigd peri-en postoperatieve analgetische management en antistolling. 14-16 Onze technieken beschreven in dit document aan te tonen dit geoptimaliseerde techniek voor microchirurgische creatie van arteriële bifurcatie aneurysma&#39;s.

Watch this Scientific Journal Video about Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects at JoVE.com

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Een geoptimaliseerde techniek voor de microchirurgische creatie van arteriële bifurcatie aneurysma&#39;s na te bootsen bifurcatie menselijke cerebrale aneurysma&#39;s is beschreven. Een veneuze zakje wordt gehecht in een kunstmatig gecreëerde echte splitsing van beide gemeenschappelijke halsslagaders. Vergemakkelijkte microchirurgische technieken en agressief postoperatieve antistolling en analgesie leiden tot een minimale morbiditeit en hoge aneurysma doorgankelijkheid tarieven.

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