Name: microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects
Uploaded: 2011-05-11T13:00:00
Description: Watch this Scientific Journal Video about Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects at JoVE.com

Este estudo foi apoiado pelo &quot;Fundo Médico-Científico do major da cidade de Viena &#39;e Biosurgery Ethicon, Inc. New Jersey, EUA. Os autores expressam seus agradecimentos ao Professor Heber Ferraz-Leite, Director do &quot;Seminário Europeu sobre Microcirurgia e Revascularização Cerebral&quot;, da Universidade Médica de Viena, na Áustria, por seu ensinamento valioso microcirúrgica.

1. Posicionamento e preparação do animal Os experimentos foram aprovados pelo comitê local responsável ética e realizada de acordo com as diretrizes Felasa. <ol><li> Iniciar a anestesia geral da fêmea de coelho Nova Zelândia Branco (2,5-3,5 kg) com injeção intramuscular de cetamina (30mg/kg) e xilazina (6mg/kg) e continuar após intubação mecânica (diâmetro do tubo de 4mm, comprimento 18mm) com anestesia de gás ( ) isoflurano sob monitorização ECG. Realizar o monitoramento ...

<ol>
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Os autores recomendam a consideração o seguinte crítica cirúrgica passos fundamentais para obter bons resultados e aneurismas de patentes: <ol><li> Dissecção cuidadosa de um longo segmento da CCA esquerda para anastomose fácil, sem destruição de nervos e vasos de pequeno porte. </li><li> Remoção cuidadosa do tecido fibroso altamente trombogênico periadventicial antes da criação da anastomose. </li><li> Criação de uma anastomose sem tensão. </li><li> Suturas menos: A sequência proposta de sites anas...

<table border="1"><tbody><tr><th> Nome do reagente </th><th> Companhia </th><th> Número de catálogo </th><th> Comentários </th></tr><tr><td> Vicryl4-0 polyfilament suturas restorable </td><td> Ethicon Inc </td><td> J386H </td><td></td></tr><tr><td> Ethilon 10-0 monofios não suturas reabsorvíveis </td><td> Ethicon Inc </td><td> 2814 </td><td> agulha de ponto de taper </td></tr><tr><td> EVICEL Bioglue </td><td> Ethicon Biosurgery Inc. </td><td> 3901 </td><td></td></tr><tr><td> Fentanil mancha cutânea 12,5 mg / h </td><td></td><td></td><td> Qualquer genericon </td></tr><tr><td> Heparina </td><td></td><td></td><td> Qualquer genericon </td></tr><tr><td> Saline 0,9% </td><td></td><td></td><td> Qualquer genericon </td></tr><tr><td> 4% Papaverin HCl </td><td></td><td></td><td> Qualquer genericon </td></tr><tr><td> Sulfato de neomicina 5 mg / ml </td><td></td><td></td><td> Qualquer genericon </td></tr><tr><td> Cetamina 50mg/ml </td><td></td><td></td><td> Qualquer genericon </td></tr><tr><td> Xilazina 20mg/ml </td><td></td><td></td><td> Qualquer genericon </td></tr></tbody></table>

microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects

Para ruptura humana aneurismas cerebrais embolização endovascular tornou-se uma alternativa equivalente a clipping aneurisma 1. Entretanto, grandes ensaios clínicos mostraram decepcionantes resultados a longo prazo com altas taxas inaceitáveis ​​de recanalização do aneurisma e ruptura do aneurisma atrasado. 2 Para superar esses problemas, estudos experimentais em animais são cruciais para o desenvolvimento de melhores dispositivos endovasculares. 3-5 Diversos modelos animais em ratos, coelhos, caninos e suínos estão disponíveis. 6-8 Comparações dos diferentes modelos animais mostraram a superioridade do modelo de coelho em relação à hemodinâmica e comparabilidade do sistema de coagulação e de custo-efetividade. 9-11 A bolsa modelo de bifurcação venosa arterial em coelhos é formado por uma bolsa venosa suturada em uma bifurcação criadas artificialmente verdadeiro de ambas as artérias carótida comum (ACC). A principal vantagem deste modelo são verdadeiras hemodinâmica bifurcational. 12 As principais dificuldades são as exigências de microcirurgia sofar alto nível técnico e alta morbidade e mortalidade de até 50% 13. Essas limitações têm resultado em menos uso freqüente deste modelo aneurisma na recente anos. Estas deficiências podem ser superadas com melhoria dos procedimentos cirúrgicos e modificado peri-e pós-operatório e gestão analgetic anticoagulação. 14-16 Nossas técnicas relatado neste artigo demonstrar esta técnica para a criação otimizada microcirúrgica dos aneurismas da bifurcação arterial.

Watch this Scientific Journal Video about Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects at JoVE.com

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Uma técnica para a criação otimizada microcirúrgica dos aneurismas da bifurcação arterial imitando bifurcação humana aneurismas cerebrais é descrita. Uma bolsa venosa é suturada em uma bifurcação criadas artificialmente verdadeiro de ambas as artérias carótida comum. Técnicas microcirúrgicas facilitado e anticoagulação pós-operatória agressiva e analgesia levar a taxas de morbidade minimizados e bons índices de permeabilidade aneurisma.

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