Name: microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects
Uploaded: 2011-05-11T13:00:00
Description: Watch this Scientific Journal Video about Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects at JoVE.com

Denna studie stöddes av &quot;medicinsk vetenskaplig fond för Major i staden Wien och Ethicon Biosurgery, Inc. New Jersey, USA. Författarna uttrycker sin tack till professor Heber Ferraz-Leite, chef för europeiska workshop om mikrokirurgi och Cerebral revaskularisering &quot;vid medicinska universitetet i Wien, Österrike, för hans värdefulla mikrokirurgisk undervisning.

1. Positionering och förberedelse av djuret Experimenten har godkänts av ansvariga lokala etiska kommittén och utförs enligt Felasa riktlinjer. <ol><li> Start narkos av de kvinnliga Nya Zeeland Vit kanin (2,5-3,5 kg) med intramuskulär injektion av Ketamin (30mg/kg) och Xylazine (6mg/kg) och fortsätter efter mekanisk intubation (rördiameter 4mm, längd 18mm) med gas anestesi ( isofluran) under EKG-övervakning. Utför smärta övervakning via tå nypa alla 15 minuter och anpassa anes...

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D., O'Reilly, G. V. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Production+of+experimental+aneurysms+at+a+surgically+created+arterial+bifurcation.">Production of experimental aneurysms at a surgically created arterial bifurcation.</a> AJNR Am J Neuroradiol. 10, 400-402 (1989).</li></ol>

Författarna rekommenderar att hänsynsfull följande kritiska kirurgiska viktiga steg för att uppnå goda resultat och aneurysm patent: <ol><li> Noggrann dissektion av en lång del av den vänstra CCA för enkel anastomos utan förstörelse av nerver och små fartyg. </li><li> Noggrann borttagning av mycket trombogena periadventitial bindvävsbildning före skapandet av anastomos. </li><li> Skapande av en tensionless anastomos. </li><li> Färre suturer: Den föreslagna sekvensen av anastomsis platser börjar på b...

<table border="1"><tbody><tr><th> Reagensets namn </th><th> Företag </th><th> Katalognummer </th><th> Kommentarer </th></tr><tr><td> Vicryl4-0 polyfilament restorable suturer </td><td> Ethicon Inc </td><td> J386H </td><td></td></tr><tr><td> Ethilon 10-0 monofil icke resorberbar sutur </td><td> Ethicon Inc </td><td> 2814 </td><td> koniska punkt nål </td></tr><tr><td> EVICEL Bioglue </td><td> Ethicon Biosurgery Inc. </td><td> 3901 </td><td></td></tr><tr><td> Fentanyl dermatologiska 12,5 mikrogram / timme </td><td></td><td></td><td> Alla genericon </td></tr><tr><td> Heparin </td><td></td><td></td><td> Alla genericon </td></tr><tr><td> 0,9% koksaltlösning </td><td></td><td></td><td> Alla genericon </td></tr><tr><td> 4% Papaverin HCl </td><td></td><td></td><td> Alla genericon </td></tr><tr><td> Neomycinsulfat 5 mg / ml </td><td></td><td></td><td> Alla genericon </td></tr><tr><td> Ketamin 50mg/ml </td><td></td><td></td><td> Alla genericon </td></tr><tr><td> Xylazine 20mg/ml </td><td></td><td></td><td> Alla genericon </td></tr></tbody></table>

microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects

För brusten människa cerebral aneurysm endovaskulär embolisering har blivit ett likvärdigt alternativ till aneurysm klippning. 1 har dock stora kliniska studier visat nedslående resultat på lång sikt med oacceptabelt hög aneurysm recanalization och försenad rupturerat aneurysm. Att övervinna dessa problem 2, djur-experimentella studier är avgörande för utvecklingen av bättre utrustning för transluminal kirurgi. 3-5 Flera djurmodeller hos råttor, kaniner, hundar och svin finns. 6-8 Jämförelser av olika djurmodeller visade överlägsenhet kanin modell med avseende på hemodynamik och jämförbarhet av koagulationssystemet och kostnadseffektivitet. 9-11 Den venösa påsen arteriell bifurkation modell kaniner bildas genom ett venöst påse sys in i ett konstlat sant bifurkation av både vanliga halspulsåder (CCA). Den största fördelen med denna modell är sanna bifurcational hemodynamiken. 12 De stora nackdelarna är Sofar höga mikrokirurgisk tekniska krav och hög sjuklighet och dödlighet på upp till 50%. 13 Dessa begränsningar har resulterat i mindre frekventa användningen av denna aneurysm modell i den senaste år. Dessa brister skulle kunna lösas med förbättrade kirurgiska ingrepp och modifierad peri-och postoperativa analgetisk ledning och antikoagulation. 14-16 Vår tekniker som redovisas i denna uppsats visa detta optimerad teknik för mikrokirurgisk skapande av arteriell bifurkation aneurysm.

Watch this Scientific Journal Video about Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects at JoVE.com

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

En optimerad teknik för mikrokirurgisk skapande av arteriell bifurkation aneurysm imitera bifurkation mänskliga cerebral aneurysm beskrivs. En venös påse sys in i ett konstlat sant bifurkation av både vanliga halspulsåder. Underlättas mikrokirurgisk teknik och aggressiv postoperativ antikoagulation och smärtlindring leder till minimerade sjuklighet och höga aneurysm priser patency.

Mikrokirurgisk Venös Pouch Arteriell-Bifurkationen Aneurysmer i Rabbit Modell: Tekniska aspekter

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