Name: chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats
Uploaded: 2012-03-13T12:00:00
Description: Watch this Scientific Journal Video about Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats at JoVE.com

笔者想承认CCI模型贝内特和谢（1988）的原始描述。 部分支持这项工作是由国家健康与澳大利亚医学研究理事会（编号568637）和新南威尔士州办事处资助科学和医学研究为GMT。

1。慢性坐骨神经无菌技术应该用于外科手术。外科工作表面用70％乙醇消毒和灭菌准备提前无菌文书（例如，罚款的剪刀，镊子，拉钩），纱布，订书钉和棉签。对于多次手术，清洁，并用70％乙醇或干大鼠之间的珠灭菌器resterilise文书。应戴口罩，头发的帽子和无菌手套。 收缩的神经，切成约3厘米长的小件浸泡在无菌生理盐水准备铬肠缝合，以防止干燥...

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CCI是一种广泛使用的外周神经损伤模型慢性神经痛。它是相对简单的执行，并产生损伤后一个月至少有一个强大和稳定的疼痛过敏。继CCI的，大鼠表现出受伤的后肢（一起举行的脚趾和足底弯曲，脚掌外翻），以及反复晃动，守卫和受伤的暗示在场的自发痛9后肢舔的姿势异常。除了 ​​感觉障碍，一些调查显示，CCI的唤起行为障碍，如扰乱社会互动，睡眠障碍，抑郁和焦虑样行为10-...

<table border="1"><tbody><tr><td> 试剂/设备名称 </td><td> 公司 </td><td> 目录编号 </td><td> 评论 </td></tr><tr><td>艳色肠道</td><td>爱惜康</td><td>的G-211 </td><td> 4-0厚度</td></tr><tr><td>异氟醚</td><td> delvet Pty有限公司，七山，新南威尔士州</td><td> N / A </td><td></td></tr><tr><td> mersilk </td><td>爱惜康</td><td>的W-580 </td><td> 5-0厚度</td></tr><tr><td> autoclip </td><td>碧迪</td><td> 427631 </td><td> 9毫米的不锈钢</td></tr><tr><td> riodine </td><td>猎户座</td><td> R1000802F </td><td> 1％W / V碘</td></tr><tr><td>足底热镇痛仪</td><td>乌戈·巴西莱</td><td> 37370 </td><td></td></tr><tr><td>动态跖触觉的</td><td>乌戈·巴西尔é </td><td> 37400 </td><td></td></tr></tbody></table>

chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats

慢性神经性疼痛，从中央或周围神经系统的损害，是一种普遍的和虚弱的状态，影响7-18人口的1,2％。症状包括自发性疼痛（刺痛，烧灼，电休克一样），感觉迟钝，感觉异常，痛觉异常（通常非疼痛刺激产生疼痛）和痛觉过敏（增加疼痛刺激的反应）。感觉症状与行为障碍，如失眠和抑郁，病态的合作。为了研究慢性神经痛几个模仿周围神经损伤的动物模型已开发，使用最广泛的是贝内特和谢的（1988）单方面坐骨神经慢性压迫性损伤（CCI）3（ 图1）。在这里，我们提出一个表演CCI和测试疼痛过敏的方法。 CCI是在麻醉下进行，一方面通过使暴露坐骨神经亲属的切口，并通过切割之间的臀肌浅和股二头肌肌肉结缔组织。四个铬肠道结扎坐骨神经周围松散地绑在1毫米的间隔，只是阻挡而不是逮捕epineural的血流量。关闭伤口缝合肌肉和皮肤中的主食。然后，动物被允许恢复从手术前24小时开始疼痛过敏测试。 行为测试，老鼠被放入测试设备，并允许习惯于测试过程。测试的区域是中旬的后肢跖面（ 图2），属于坐骨神经分布区域内。通过机械刺激使用电子动态足底冯弗雷触觉或手册·冯·弗雷毛发4受伤和未受伤的后爪机械痛阈值评估。机械撤出门槛是施加最大的压力（克），触发爪子撤出。热退缩潜伏期哈格里夫斯等人 （1988）首次描述，测量，后肢被暴露在辐射热束通过一个透明的玻璃表面，使用足底镇痛米5,6。记录的时间为受伤和未受伤的后爪缩爪退缩潜伏期的热量刺激。继CCI的，机械的退出门槛，以及受伤的爪子热退缩潜伏期均明显减少，比基线测量和未受伤的爪子（ 图3）。周围神经损伤与疼痛过敏测试相结合的CCI模型提供了一个模型系统调查的潜在治疗药物的有效性，修改慢性神经性疼痛。在我们的实验室中，我们利用热和机械灵敏度的后爪一起CCI调查的发病机制的神经免疫相互作用的作用治疗神经性疼痛。

Watch this Scientific Journal Video about Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats at JoVE.com

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

由于手术简单和健壮的行为结果，坐骨神经慢性缩窄是神经​​痛卓越的动物模型之一。手术后24小时内，疼痛过敏建立并可以使用冯弗雷触觉（机械测试）和足底的镇痛米（热试验）的定量测​​定。

慢性缩窄大鼠坐骨神经疼痛过敏测试

Chronic neuropathic pain, resulting from damage to the central or peripheral nervous system, is a prevalent and debilitating condition, affecting 7-18% of ...

Research

JoVE Journal

Medicine

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

在大鼠脊髓损伤后的急性和慢性触觉测试

Spinal cord injury (SCI) impairs sensory systems causing allodynia1-8. To identify cellular and molecular causes of allodynia, sensitive and valid sensory ...

科研

医学

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

大鼠建立压力超负荷心肌肥厚模型在升主动脉缩窄

Ascending aortic constriction is the most common and successful surgical model for creating pressure overload induced cardiac hypertrophy and heart ...

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

膀胱胀诱发内脏运动反应为膀胱疼痛小鼠模型

Approximately 3-8 million people in the United States suffer from interstitial cystitis/bladder pain syndrome (IC/BPS), a debilitating condition ...

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

神经病理性疼痛小鼠坐骨神经掴型号

Neuropathic pain arises as a consequence of a lesion or a disease affecting the somatosensory system. This syndrome results from maladaptive changes in ...

Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain

Chronic Constriction Injury of the Rat's Infraorbital Nerve IoN-CCI to Study Trigeminal Neuropathic Pain

老鼠的眶下神经（ION-CCI）研究三叉神经性疼痛性损伤

Animal models are important tools to study the pathophysiology and pharmacology of neuropathic pain. This manuscript describes the surgical and behavioral ...

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

心脏重构通过大鼠腹主动脉缩窄的模型

Heart failure is one of the leading causes of death worldwide. It is a complex clinical syndromethat includes fatigue, dyspnea, exercise intolerance, and ...

Histological Quantification of Chronic Myocardial Infarct in Rats

大鼠慢性心肌梗塞的组织学定量分析

Myocardial infarction is defined as cardiomyocyte death due to prolonged ischemia; an inflammatory response and scar formation (fibrosis) follow the ...

Minimally Invasive Transverse Aortic Constriction in Mice

微创横向主动脉缩窄小鼠

Minimally invasive transverse aortic constriction (MTAC) is a more desirable method for the constriction of the transverse aorta in mice than standard ...

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

皮下三叉神经场刺激难治性面部疼痛

Chronic or neuropathic trigeminal facial pain can be challenging to treat. Neurosurgical procedures should be applied when conservative treatment fails. ...

Development of Recombinant Proteins to Treat Chronic Pain

重组蛋白治疗慢性疼痛的研究进展

Chronic pain is difficult to treat and new approaches to resolve persistent pain are urgently needed. Anti-inflammatory cytokines are promising candidates ...