Name: synthetic, multi-layer, self-oscillating vocal fold model fabrication
Uploaded: 2011-12-02T12:00:00
Description: Watch this Scientific Journal Video about Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication at JoVE.com

作者感谢支持合成模型开发的国家耳聋与其他交流障碍研究所的资助R03DC8200，R01DC9616和R01DC5788。

制造序列（ 见图1）由声带模型层的模具，连续铸造硅层，并安装测试模型。该模型有四个不同的层次：身体，韧带，浅固有层和上皮细胞，除了单根光纤。后盾层添加声带模式，以方便个别层的准确位置。该模型的几何参数的定义见图 。 2，表1给出当前模型的参数值。在下面的章节，不同的有机硅混合比例指定为不同的层，这些生产材料的特性类似人类的<...

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这种方法制造合成声带模型产量模型，表现出类似人类的声带的振动行为。多层次的概念，结果在减少发病的压力和改进模型运动方面的显著优势超过以前的一，二层模型设计3,6,8,15，（会聚发散振荡，粘膜波浪状运动期间的形象，并减少劣质优越的位移）。这里介绍的方法是表明一个有点理想化的模型，在几何方面，但它可以适用于不同的几何形状的模型。例如，对人体成像的几何数据...

<table border="1"&gt;<tbody&gt;<tr&gt;<td<strong&gt;试剂名称</strong</td&gt;<td<strong&gt;公司</strong</td&gt;<td<strong&gt;目录编号</strong</td&gt;<td<strong&gt;评论</strong</td&gt;</tr&gt;<tr&gt;<td&gt;高真空润滑脂</td&gt;<td&gt;道康宁</td&gt;<td&gt; 01018817</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt; POL - EASE 2300</td&gt;<td&gt; Polytek</td&gt;<td&gt; POL - Ease2300 - 1</td&gt;<td&gt;脱模剂</td&gt;</tr&gt;<tr&gt;<td&gt;光滑银950</td&gt;<td&gt;平滑</td&gt;<td&gt;光滑银950</td&gt;<td&gt;模具制造材料</td&gt;</tr&gt;<tr&gt;<td&gt;真空泵</td&gt;<td&gt;爱德华兹</td&gt;<td&gt; E2M2</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;真空室</td&gt;<td&gt; Kartell的</td&gt;<td&gt; 230</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;压力表</td&gt;<td&gt;沼泽Bellofram</td&gt;<td&gt; 11308252A</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;直线型刀片</td&gt;<td&gt;赫斯基</td&gt;<td&gt; 008 - 045 - HKY</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;的Ecoflex 00-30</td&gt;<td&gt;平滑</td&gt;<td&gt;的Ecoflex 00-30</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;硅胶稀释剂</td&gt;<td&gt;平滑</td&gt;<td&gt;硅胶稀释剂</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;龙皮肤</td&gt;<td&gt;平滑</td&gt;<td&gt;龙皮肤10快速</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;发新话题</td&gt;<td&gt;欧米茄</td&gt;<td&gt; OmegaCrys</td&gt;<td&gt;仅使用明确的纤维</td&gt;</tr&gt;<tr&gt;<td&gt;硅胶染料</td&gt;<td&gt;平滑</td&gt;<td&gt; SILC猪黑</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;硅酮胶</td&gt;<td&gt;平滑</td&gt;<td&gt;银，Poxy</td&gt;<td</td&gt;</tr&gt;<tr&gt;<td&gt;滑石粉</td&gt;<td&gt;西方家庭</td&gt;<td</td&gt;<td</td&gt;</tr&gt;</tbody&gt;</table

synthetic, multi-layer, self-oscillating vocal fold model fabrication

人类语音的声音是通过流引起的声带振动产生。声带由几层组织，各有不同的材料特性 1 。正常的语音生产依赖于健康的组织和声带，空气动力学，结构动力学和声学物理现象之间的复杂耦合的结果发生。语音障碍影响到750万，每年在美国就有2，往往会造成显著的财政，社会，和其他质量的生活困难。了解语音生产的物理学有可能显著受益语音服务，包括临床的预防，诊断，和治疗语音障碍。 现有的方法， 包括在研究语音生产的体内实验使用人类和动物的科目 ，在体外实验使用切除larynges和合成模型和计算模型ING。由于危险和困难的仪器访问，在体内实验中是极为有限的范围。切除喉实验解剖和某些生理现实主义的利益，但涉及几何和材料的属性变量的参数的研究是有限的。此外，他们通常只能是相对较短的时间周期（通常是为了分钟）振捣的。 克服部分切除喉实验的局限性，合成声带模式正在成为一个研究语音生产的辅助工具。可以制备合成模型与几何形状和材料性质的系统性变化，从而为人类健康和不健康的发声空气动力学，结构动力学，和声学研究。例如，他们已被用于研究左，右声带不对称3,4，临床仪器开发5，喉空气动力学6-9，VOC人接触压力10倍，并声门下声学11（更全面的清单中可以找到Kniesburges 等 12 ） 然而，现有合成声带模型，被同质（1层模型），或已采用两个不同刚度的材料（两层模型）。这种方法不允许起着核心作用声带流激振动响应的人类 1声带实际的多层结构的代表性。因此，一个和两个层合成声带模型已经表现出的缺点，如比什么是典型的人类发声（发病压力是最小的肺压力，要求启动振动），人为地大量劣质的高发病压力3,6,8卓越的运动，缺乏一个“粘膜波”（一个垂直行波的特点是健康人的声带振动）。 <pCLASS =“jove_content”&gt;在本文中，制造与多种不同的材料特性层模式的描述。层模型模拟人类的声带，包括上皮，浅固有层（SLP），中级和深固有层的多​​层结构（即，韧带，前后刚度包括光纤）和肌肉（即体）第1层。前结果，表明该模型展品改善振动特性和两层的合成模型，包括发病的压力更接近人类发病压力，减少劣质卓越的运动，和粘膜波的证据。

Watch this Scientific Journal Video about Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication at JoVE.com

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication

用于制造合成声带模型的方法描述。该机型是等身和模仿人类声带的多层结构。结果表明，模型自振荡压力与肺压力和展示类似人类声带的流激振动响应。

合成，多层，自激振荡的声带模型制作

Sound for the human voice is produced via flow-induced vocal fold vibration. The vocal folds consist of several layers of tissue, each with differing ...

Research

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The  method described here consists in redesigning E. coli adherence properties by assembling the minimum number of  curli genes under the control of a ...

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Investigating the Three-dimensional Flow Separation Induced by a Model Vocal Fold Polyp

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