Name: real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety
Uploaded: 2012-01-20T13:00:00
Description: Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Denne undersøgelse er finansieret af NIH (R21 MH090384, R01 EB006494, RO1 EB009666, R01 NS051622). Vi takker H. Sarofin og C. Lacadie for deres tekniske assistance.

1. Stimulus Udvikling Omfattende stimulus udvikling er nødvendig. Forurening-relaterede og neutrale billeder skal indsamles og afprøves for at sikre den angst forårsaget af disse stimuli, er afbalanceret på tværs af provokation betingelser og signifikant større i provokation betingelser end i de neutrale Mere specifikt er følgende fire stimulus sæt nødvendigt.: <ol><li> Localizer stimuli: 300 forurening-relaterede billeder og 300 neutrale billeder...

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Biofeedback af real-time fMRI data er en ny teknik og mere arbejde er nødvendigt for at optimere denne metode for at maksimere læring i fag. Nylige undersøgelser har udforsket hvordan læring ændrer sig med forskellige antal kørsler eller scanning sessioner, 14, 18, ​​27, hvordan de tilbagemeldinger paradigme påvirker indlæring 28, og om læringen forårsaget af en given biofeedback protokol resulterer i ændringer i hjernens funktion, der fortsat over slutningen af biofeedback praktikpe...

real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety

Vi præsenterer en metode til træning fag til at styre aktivitet i en region på deres orbitofrontal cortex er forbundet med forurening angst ved hjælp af biofeedback i real-tid funktionel magnetisk resonans imaging (rt-fMRI) data. Øget aktivitet i denne region ses i forhold til forurening angst både i kontrolgruppen 1 og hos personer med obsessiv-kompulsiv sygdom (OCD), 2 en forholdsvis almindelig og ofte invaliderende psykisk lidelse der involverer forurening angst. Selv om mange områder af hjernen har været impliceret i OCD, abnormitet i orbitofrontal cortex (OFC) er en af de mest konsistente resultater. 3, 4 Desuden hyperaktivitet i OFC har vist sig at korrelere med OCD symptom sværhedsgrad 5 og fald i hyperaktivitet i denne region har været rapporteret at korrelere med nedsat symptom sværhedsgrad. 6 Derfor kan evnen til at kontrollere denne hjerne området udmønte sig i CLinical forbedringer i obsessiv-kompulsiv symptomer, herunder forurening angst. Biofeedback af RT-fMRI data er en ny teknik, hvor den tidsmæssige mønster af aktivitet i en bestemt region (eller tilknyttet et bestemt distribueret mønster af hjernens aktivitet) i et fag hjerne er fastsat som et feedback-signal til emnet. De seneste rapporter tyder på, at mennesker er i stand til at udvikle kontrol over aktiviteten af specifikke områder i hjernen, når de har RT-fMRI biofeedback. 7-12 Især flere undersøgelser at bruge denne teknik til at målrette områder i hjernen der er involveret i følelser forarbejdning, har rapporteret succes med at træne fag at kontrollere disse regioner. 13-18 I flere tilfælde har RT-fMRI biofeedback træning blevet rapporteret at inducere kognitive, emotionelle eller kliniske forandringer i fag. 8, 9, 13, 19 Her viser vi denne teknik, som anvendes til behandling af forurening angst hos raske forsøgspersoner. Dette biofeedback intervention vil være en værdifuld basIC forskning værktøj: det giver mulighed for forskerne til at forstyrrer hjernens funktion, måle de deraf følgende ændringer i hjernens dynamik og relatere dem til ændringer i kontaminering angst eller andre adfærdsmæssige tiltag. Desuden tjener etableringen af ​​denne metode som et første skridt hen imod undersøgelsen af ​​fMRI-baserede biofeedback som et terapeutisk intervention for OCD. I betragtning af, at cirka en fjerdedel af patienter med OCD får ringe gavn af de tilgængelige former for behandling, 20-22, og at de, der nyder godt sjældent kommer sig fuldstændigt, er en ny tilgang til behandling af denne population presserende behov.

Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Her præsenterer vi en metode til at uddanne folk til at styre en hjerne område, der er involveret i forurening angst og til sondering forholdet mellem forurening angst og hjerne tilslutningsmuligheder mønstre.

Real-time fMRI Biofeedback Målretning af orbitofrontal Cortex for forurening Angst

We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using ...

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