Name: real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety
Uploaded: 2012-01-20T13:00:00
Description: Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Dit onderzoek wordt gefinancierd door NIH (R21 MH090384, R01 EB006494, RO1 EB009666, R01 NS051622). Wij danken H. Sarofin en C. Lacadie voor hun technische bijstand.

1. Stimulus Ontwikkeling Uitgebreide stimulans ontwikkeling nodig is. Contaminatie-gerelateerde en neutrale beelden moeten worden verzameld en gestuurd om ervoor te zorgen de angst veroorzaakt door deze stimuli is evenwichtiger gespreid over de provocatie voorwaarden en significant groter in de provocatie omstandigheden dan in de neutrale Meer specifiek, de volgende vier stimulus sets nodig zijn.: <ol><li> Localizer stimuli: 300 contaminatie-gerelateerde a...

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Biofeedback van real-time data fMRI is een nieuwe techniek en nog veel meer werk is nodig om deze methode te optimaliseren, zodat als het maximaliseren van het leren in vakken. Recente studies hebben onderzocht hoe het leren verandert met verschillende aantallen loopt of het scannen van sessies, 14, 18, ​​27 hoe de feedback paradigma van invloed op het leren 28, en of het leren veroorzaakt door een bepaalde biofeedback protocol resulteert in veranderingen in de hersenfunctie die blijven bestaan...

real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety

We presenteren een methode voor de opleiding van proefpersonen de activiteit controle in een regio van hun orbitofrontale cortex geassocieerd met vervuiling angst met behulp van biofeedback van real-time functionele magnetische resonantie beeldvorming (fMRI rt-) gegevens. Verhoogde activiteit van dit gebied wordt gezien in relatie met de besmetting angst zowel in de controlegroep 1 en bij personen met een obsessief-compulsieve stoornis (OCS), 2 een relatief veel voorkomende en vaak slopende psychiatrische stoornis met betrekking tot verontreiniging angst. Hoewel veel gebieden van de hersenen zijn betrokken bij OCS, afwijking in de orbitofrontale cortex (OFC) is een van de meest consistente bevindingen. 3, 4 Bovendien, hyperactiviteit in de OFC is gevonden correleert met OCD ernst van de symptomen 5 en dalingen van hyperactiviteit bij deze regio zijn gemeld correleren met een verminderde ernst van de symptomen. 6 Daarom is de mogelijkheid om dit hersengebied controle kan vertalen in clinical verbeteringen in de obsessief-compulsieve symptomen met inbegrip van vervuiling angst. Biofeedback van rt-fMRI data is een nieuwe techniek waarbij de tijdelijke patroon van activiteit in een bepaalde regio (of geassocieerd met een specifieke verdeelde patroon van hersenactiviteit) in de hersenen van een onderwerp wordt geleverd als een feedback signaal naar het onderwerp. Recente rapporten geven aan dat mensen in staat zijn de controle over de activiteit van bepaalde hersengebieden te ontwikkelen wanneer voorzien van een rt-fMRI biofeedback. 7-12 in het bijzonder, verschillende studies met behulp van deze techniek om hersengebieden die betrokken zijn bij de verwerking van emoties beoogde succes hebben gemeld in opleiding onderwerpen om de controle van deze regio&#39;s. 13-18 In een aantal gevallen heeft rt-fMRI biofeedback training is gemeld dat cognitieve, emotionele of klinische veranderingen bij patiënten te veroorzaken. 8, 9, 13, 19 Hier hebben we deze techniek illustreren zoals toegepast bij de behandeling van verontreiniging angst bij gezonde proefpersonen. Deze biofeedback interventie zal een waardevolle basic research tool: het stelt onderzoekers in staat te verstoren hersenfunctie, de daaruit voortvloeiende veranderingen in de hersenen te meten en de dynamiek die betrekking hebben op veranderingen in de verontreiniging angst of andere gedrags-maatregelen. Daarnaast is de oprichting van deze methode dient als een eerste stap naar het onderzoek van fMRI-based biofeedback als een therapeutische interventie voor OCD. Gezien het feit dat ongeveer een kwart van de patiënten met OCS kleine uitkering van de momenteel beschikbare vormen van behandeling, 20-22 en dat degenen die toch baat hebben zelden volledig te herstellen, nieuwe benaderingen voor de behandeling van deze populatie zijn dringend nodig.

Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Hier presenteren we een methode voor het trainen van mensen om een ​​hersengebied betrokken is bij besmetting angst controle en voor het sonderen van de relatie tussen de besmetting angst en de hersenen connectiviteit patronen.

Real-time fMRI Biofeedback Gericht op de orbitofrontale cortex voor besmetting Angst

We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using ...

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