Name: real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety
Uploaded: 2012-01-20T13:00:00
Description: Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Diese Studie wird von NIH (R21 MH090384, R01 EB006494, RO1 EB009666, R01 NS051622) finanziert. Wir danken H. Sarofin und C. Lacadie für ihre technische Unterstützung.

1. Stimulus-Entwicklung Umfangreiche Reiz Entwicklung erforderlich ist. Kontamination im Zusammenhang mit und neutrale Bilder müssen gesammelt und erprobt, um sicherzustellen, dass die Angst, die durch diese Stimuli induziert über Provokation Bedingungen ist ausgewogen und signifikant größer in der Provokation Bedingungen als in der neutralen Bedingungen Genauer gesagt, die folgenden vier Stimulus-Sets benötigt werden.: <ol><li> Localizer Reize: 300 K...

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Biofeedback in Echtzeit fMRI-Daten ist eine neue Technik und mehr Arbeit ist erforderlich, um diese Methode so zu optimieren, um zu maximieren Lernen in Fächern. Jüngste Studien haben, wie das Lernen verändert sich mit einer unterschiedlichen Anzahl von Läufen oder Scannen Sessions, 14, 18, ​​27 untersucht, wie das Feedback Paradigma beeinflusst Lernen 28, und ob das Lernen von einem bestimmten Biofeedback-Protokoll führt zu Veränderungen in der Gehirnfunktion, die über das Ende fortbest...

real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety

Wir stellen eine Methode zur Ausbildung Themen, um die Aktivität in einem Bereich ihrer orbitofrontalen Kortex mit der Kontamination Angst mittels Biofeedback von Echtzeit-funktionellen Magnetresonanztomographie (rt-fMRI) Daten zugeordnete Steuerelement. Erhöhte Aktivität in dieser Region ist in Zusammenarbeit mit Kontamination Angst sowohl in der Kontrollgruppe 1 und bei Personen mit Zwangsstörungen (OCD), 2 eine relativ häufige und oft beeinträchtigenden psychischen Störung mit Kontamination Angst gesehen. Obwohl viele Hirnregionen sind an OCD, Anomalie wurde in den orbitofrontalen Kortex (OFC) verwickelt ist einer der beständigsten Befunde. 3, 4 Darüber hinaus Hyperaktivität in der OFC hat sich mit OCD Symptom Schwierigkeitsgrad 5 korrelieren und sinkt in Hyperaktivität in dieser Region wurde berichtet, dass mit verminderter Schwere der Symptome zu korrelieren. 6 Darum, die Fähigkeit, dieses Hirnareal Kontrolle kann in cl übersetzeninical Verbesserungen in zwanghafte Symptome einschließlich Kontamination Angst. Biofeedback von rt-fMRI-Daten ist eine neue Technik, in der die zeitlichen Muster der Aktivität in einer bestimmten Region (oder in Verbindung mit einer spezifischen verteilten Muster neuronaler Aktivität) in ein Thema, das Gehirn als ein Feedback-Signal an das Thema vorgesehen ist. Jüngste Berichte zeigen, dass Menschen in der Lage, die Kontrolle über die Aktivität bestimmter Hirnareale zu entwickeln, wenn sie mit rt-fMRI Biofeedback zur Verfügung gestellt werden. 7-12 in allem mehrere Studien mit dieser Technik zu Hirnareale in emotion Verarbeitung beteiligt Ziel haben Erfolg in der Ausbildung Probanden berichteten um die Kontrolle über diese Regionen. 13-18 in mehreren Fällen hat rt-fMRI Biofeedback-Training wurde berichtet, dass kognitive, emotionale oder klinische Veränderungen bei Patienten zu induzieren. 8, 9, 13, 19 Hier haben wir diese Technik zu veranschaulichen, wie die Behandlung der angewandten Kontamination Angst bei gesunden Probanden. Das Biofeedback-Intervention wird ein wertvolles Flachrelief werdenic Recherche-Tool: Es erlaubt Forschern, stören die Gehirnfunktion, messen Sie die sich daraus ergebenden Veränderungen im Gehirn Dynamik und beziehen sich diese Änderungen in Kontamination Angst oder anderen Verhaltensmaßnahmen. Darüber hinaus dient die Einrichtung dieses Verfahren als ein erster Schritt zur Untersuchung von fMRI-basierten Biofeedback als therapeutische Intervention bei OCD. Da rund ein Viertel der Patienten mit einer Zwangsstörung wenig Nutzen erhalten von den derzeit verfügbaren Formen der Behandlung, 20-22 und dass diejenigen, die Nutzen haben nur selten vollständig zu erholen, neue Ansätze für die Behandlung dieser Patientengruppe sind dringend notwendig.

Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Hier präsentieren wir eine Methode zur Ausbildung von Menschen zu einem Bereich des Gehirns zu einer Kontamination Angst beteiligt Steuerung und für die Erforschung der Beziehung zwischen Verschmutzung Angst und Gehirn-Konnektivität Muster.

Real-time fMRI Biofeedback Targeting des orbitofrontalen Cortex für die Kontamination Anxiety

We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using ...

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