Name: real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety
Uploaded: 2012-01-20T13:00:00
Description: Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Questo studio è finanziato dal NIH (MH090384 R21, R01 EB006494, RO1 EB009666, R01 NS051622). Ringraziamo H. Sarofin e C. Lacadie per la loro assistenza tecnica.

1. Stimolo per lo sviluppo Stimolo allo sviluppo estensivo è necessario. Immagini contaminazione legati e neutro devono essere raccolti e pilotato per assicurare l&#39;ansia indotta da questi stimoli è equilibrata fra le diverse condizioni di provocazione e significativamente maggiore nelle condizioni di provocazione che in condizioni di neutralità Più in particolare, le seguenti quattro set di stimoli sono necessari.: <ol><li> Stimoli Localizer: 300 c...

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Biofeedback di dati in tempo reale fMRI è una tecnica nuova e più lavoro è necessario per ottimizzare questo metodo in modo da massimizzare l&#39;apprendimento nei soggetti. Recenti studi hanno esplorato come i cambiamenti di apprendimento con un diverso numero di piste o sessioni di scansione, 14, 18, ​​27 come il paradigma di feedback colpisce di apprendimento 28, e se l&#39;apprendimento indotto da un dato risultati biofeedback protocollo cambiamenti nelle funzioni cerebrali che persiston...

real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety

Vi presentiamo un metodo per i soggetti di formazione per controllare l&#39;attività in una regione della corteccia orbitofrontale associata ad ansia contaminazione con biofeedback in tempo reale risonanza magnetica funzionale (fMRI-rt) di dati. Maggiore attività di questa regione è visto in relazione con l&#39;ansia di contaminazione sia nei soggetti di controllo 1 e negli individui con disturbo ossessivo-compulsivo (OCD), 2 una malattia relativamente comune e spesso debilitanti psichiatrici che coinvolgono l&#39;ansia contaminazione. Anche se molte regioni del cervello sono stati implicati nel disturbo ossessivo compulsivo, anormalità nella corteccia orbitofrontale (OFC) è uno dei risultati più consistenti. 3, 4, inoltre, l&#39;iperattività nei OFC è stato trovato per correlano con la gravità dei sintomi OCD 5 e diminuisce in iperattività in questa regione sono stati segnalati in correlazione con la gravità dei sintomi è diminuito. 6 Perciò, la capacità di controllare questa zona del cervello può tradursi in clmiglioramenti in inical sintomi ossessivo-compulsivi tra ansia contaminazione. Biofeedback di rt-dati fMRI è una nuova tecnica in cui viene fornito lo schema temporale delle attività in una regione specifica (o associati a uno specifico modello distribuito di attività cerebrale) nel cervello di un soggetto come un segnale di feedback per il soggetto. Recenti rapporti indicano che le persone sono in grado di sviluppare il controllo sulla attività delle aree cerebrali specifiche, ove previsto, con rt-fMRI biofeedback. 7-12, in particolare, diversi studi utilizzando questa tecnica per indirizzare le aree del cervello coinvolte nella lavorazione emozione hanno riportato successi in soggetti di formazione per controllare queste regioni. 13-18 In diversi casi, rt-fMRI formazione biofeedback è stato segnalato per indurre cambiamenti cognitivi, emotivi, o clinico con soggetti. 8, 9, 13, 19 Qui si illustrano questa tecnica applicata al trattamento dei ansia contaminazione nei soggetti sani. Questo intervento biofeedback sarà un prezioso bassorilievoic strumento di ricerca: permette ai ricercatori di perturbare le funzioni cerebrali, misurare le conseguenti modifiche delle dinamiche cerebrali e quelli relativi alle variazioni di ansia contaminazione o altre misure comportamentali. Inoltre, l&#39;istituzione di questo metodo serve come primo passo verso l&#39;indagine di risonanza magnetica funzionale a base di biofeedback come intervento terapeutico per OCD. Dato che circa un quarto dei pazienti con disturbo ossessivo compulsivo ricevono scarso beneficio dalle forme attualmente disponibili di trattamento, 20-22 e che coloro che ne beneficiano raramente guariscono completamente, nuovi approcci per il trattamento di questa popolazione sono urgentemente necessari.

Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Qui vi presentiamo un metodo per formare le persone per controllare una zona del cervello coinvolta in ansia contaminazione e per sondare il rapporto tra ansia contaminazione e modelli di connettività cerebrale.

In tempo reale Biofeedback fMRI Targeting la corteccia orbito-frontale per l&#39;ansia di contaminazione

We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using ...

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