Name: real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety
Uploaded: 2012-01-20T13:00:00
Description: Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Denne studien er finansiert av NIH (R21 MH090384, R01 EB006494, RO1 EB009666, R01 NS051622). Vi takker H. Sarofin og C. Lacadie for deres tekniske assistanse.

1. Stimulus Development Omfattende stimulus utvikling er nødvendig. Forurensning-relaterte og nøytrale bilder må samles inn og styrt for å sikre at angst indusert av disse stimuli er balansert tvers provokasjon forhold og betydelig større i provokasjon vilkår enn i det nøytrale forhold Mer spesifikt, er følgende fire stimulus setter nødvendig. <ol><li> Localizer stimuli: 300 kontaminering-relaterte bilder og 300 nøytrale bilder er brukt til å lo...

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Biofeedback i sanntid fMRI-data er en ny teknikk og mer arbeid er nødvendig for å optimalisere denne metoden, slik som å maksimere læring i fag. Nyere studier har undersøkt hvordan læring endringer med forskjellige antall runder eller scanning økter, 14, 18, ​​27 hvordan feedback paradigmet påvirker læring 28, og hvorvidt læring indusert av en gitt biofeedback protokoll resulterer i forandringer i hjernens funksjon som vedvarer utover slutten av biofeedback trening perioden. 15, ...

real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety

Vi presenterer en metode for trening fag å styre aktivitet i en region av deres orbitofrontal cortex forbundet med forurensning angst ved hjelp av biofeedback av sanntids funksjonell magnetisk resonans imaging (rt-fMRI) data. Økt aktivitet i denne regionen er sett i forhold til forurensning angst både hos kontrollpersonene 1 og hos personer med tvangslidelser (OCD), 2 en relativt vanlig og ofte ødeleggende psykiatrisk lidelse som involverer forurensning angst. Selv om mange områder av hjernen har vært innblandet i OCD, abnormitet i orbitofrontal cortex (OFC) er en av de mest konsistente funn. 3, 4 Videre hyperaktivitet i OFC har blitt funnet å korrelere med OCD symptom alvorlighetsgrad 5 og reduksjon i hyperaktivitet i denne regionen har blitt rapportert å korrelere med redusert symptom alvorlighetsgrad. 6 Derfor kan evnen til å kontrollere dette hjernen oversette til clinical forbedringer i obsessive-compulsive symptomer inkludert forurensning angst. Biofeedback av RT-fMRI-data er en ny teknikk der timelige mønster av aktivitet i en bestemt region (eller assosiert med en bestemt distribuert mønster av hjernens aktivitet) i et fag hjerne er gitt som en tilbakemelding signal til emnet. Nye rapporter indikerer at folk er i stand til å utvikle kontroll over aktiviteten til spesifikke hjerne områder når det følger med rt-fMRI biofeedback. Har 7-12 Særlig flere studier bruker denne teknikken til å målrette hjernen områder involvert i følelser behandling rapportert suksess i trening fagene å kontrollere disse regionene. 13-18 I flere tilfeller har rt-fMRI biofeedback trening blitt rapportert å indusere kognitive, emosjonelle, eller kliniske endringer i fag. 8, 9, 13, 19 Her ser vi illustrere denne teknikken som brukes til behandling av forurensning angst hos friske forsøkspersoner. Dette biofeedback intervensjon vil være et verdifullt basic forskning verktøy: det tillater forskere å forstyrre hjernens funksjon, måler den resulterende endringer i hjernens dynamikk og relaterer dem til endringer i forurensning angst eller andre atferdsmessige tiltak. I tillegg serverer etableringen av denne metoden som et første skritt mot etterforskningen av fMRI-baserte biofeedback som en terapeutisk intervensjon for OCD. Gitt at ca en fjerdedel av pasienter med tvangslidelse får liten nytte av de tilgjengelige formene for behandling, 20-22 og at de som gjør nytte sjelden blir helt friske, nye tilnærminger for å behandle denne pasientgruppen stort behov.

Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Her presenterer vi en metode for opplæring folk å kontrollere en hjerne område involvert i forurensning angst og for undersøkelser av sammenhengen mellom forurensning angst og hjernen tilkoblingsmuligheter mønstre.

Real-time fMRI Biofeedback Targeting den Orbitofrontal Cortex for forurensning Angst

We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using ...

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