Name: real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety
Uploaded: 2012-01-20T13:00:00
Description: Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Это исследование финансируется NIH (R21 MH090384, R01 EB006494, RO1 EB009666, R01 NS051622). Мы благодарим H. Sarofin и С. Lacadie за их техническую помощь.

1. Стимул развития Экстенсивное развитие стимулов не требуется. Загрязнение связанных и нейтральные изображения должны быть собраны и для обеспечения пилотируемых тревоги, вызываемых этими стимулами является сбалансированным по провокация условия и значительно б?...

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Биологическая обратная связь в режиме реального времени данные МРТ является новой техники и многое еще предстоит сделать, чтобы оптимизировать этот метод так, чтобы максимизировать обучения по предметам. Недавние исследования изучали, как обучение изменения с различным числом работ?...

real-time fmri biofeedback targeting the orbitofrontal cortex for contamination anxiety

We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using biofeedback of real-time functional magnetic resonance imaging (rt-fMRI) data. Increased activity of this region is seen in relationship with contamination anxiety both in control subjects1 and in individuals with obsessive-compulsive disorder (OCD),2 a relatively common and often debilitating psychiatric disorder involving contamination anxiety. Although many brain regions have been implicated in OCD, abnormality in the orbitofrontal cortex (OFC) is one of the most consistent findings.3, 4 Furthermore, hyperactivity in the OFC has been found to correlate with OCD symptom severity5 and decreases in hyperactivity in this region have been reported to correlate with decreased symptom severity.6 Therefore, the ability to control this brain area may translate into clinical improvements in obsessive-compulsive symptoms including contamination anxiety. Biofeedback of rt-fMRI data is a new technique in which the temporal pattern of activity in a specific region (or associated with a specific distributed pattern of brain activity) in a subject's brain is provided as a feedback signal to the subject. Recent reports indicate that people are able to develop control over the activity of specific brain areas when provided with rt-fMRI biofeedback.7-12 In particular, several studies using this technique to target brain areas involved in emotion processing have reported success in training subjects to control these regions.13-18 In several cases, rt-fMRI biofeedback training has been reported to induce cognitive, emotional, or clinical changes in subjects.8, 9, 13, 19 Here we illustrate this technique as applied to the treatment of contamination anxiety in healthy subjects. This biofeedback intervention will be a valuable basic research tool: it allows researchers to perturb brain function, measure the resulting changes in brain dynamics and relate those to changes in contamination anxiety or other behavioral measures. In addition, the establishment of this method serves as a first step towards the investigation of fMRI-based biofeedback as a therapeutic intervention for OCD. Given that approximately a quarter of patients with OCD receive little benefit from the currently available forms of treatment,20-22 and that those who do benefit rarely recover completely, new approaches for treating this population are urgently needed.

Watch this Scientific Journal Video about Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety at JoVE.com

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Здесь мы представляем метод обучения людей для контроля область мозга, участвующих в загрязнении тревоги и для зондирования отношений между тревогой загрязнения и мозговых подключения.

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We present a method for training subjects to control activity in a region of their orbitofrontal cortex associated with contamination anxiety using ...

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