Name: the mouse forced swim test
Uploaded: 2012-01-29T14:00:00
Description: Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

وقد تم دعم هذه الدراسة من منحة NIHM R01 R21 MH091816 وMH084043 إلى TDG.

1. المواد والطريقة 1.1. وخزانات المياه الدبابات اسطوانية (30 سم × ارتفاع 20 سم بأقطار) اللازمة لاختبار الفأرة تسبح القسري (FST) في المختبر لدينا هي التي شيدت من زجاجي شفاف ، وهذه المواد هي قادرة على الص?...

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تم تطوير FST (التي تسمى أحيانا Porsolt اختبار السباحة) أولا بالنسبة للفئران وبعد ذلك لتعديل الفئران بنسبة 12،13 Porsolt وزملاؤه. بالإضافة إلى بروتوكول الموصوفة أعلاه الناجحة في المختبر لدينا ، وقد تم نشر عدد كبير من التعديلات اختبار دقيق (انظر Hascoët وبورين لاستعراض كامل <su...

<ul style=";text-align:right;direction:rtl"><li style=";text-align:right;direction:rtl"> خزانات المياه </li><li style=";text-align:right;direction:rtl"> ميزان الحرارة </li><li style=";text-align:right;direction:rtl"> مؤقت </li><li style=";text-align:right;direction:rtl"> كاميرا فيديو </li><li style=";text-align:right;direction:rtl"> مولدات الضوضاء البيضاء (اختياري) </li><li style=";text-align:right;direction:rtl"> تجفيف الورق </li></ul>

the mouse forced swim test

اختبار السباحة القسري هو اختبار القوارض السلوكية المستخدمة لتقييم العقاقير المضادة للاكتئاب والفعالية المضادة للاكتئاب من المركبات الجديدة ، والتلاعب التجريبية التي تهدف إلى تقديم أو منع الاكتئاب مثل الدول. يتم وضع الفئران في دبابة شفافة لا مفر منه أن يملأ بالماء ويتم قياس سلوكهم الهروب التنقل ذات الصلة. الاختبار القسري تسبح واضح وصريح لإجراء موثوق به ويتطلب الحد الأدنى من المعدات المتخصصة. التنفيذ الناجح لاختبار السباحة القسري يتطلب الالتزام تفاصيل إجرائية معينة والتقليل من التوتر غير المبرر للفئران. في وصف البروتوكول والفيديو المرافقة ، نجد تفسيرا لكيفية إجراء نسخة الماوس هذا الاختبار مع التركيز على المخاطر المحتملة التي قد تكون ضارة لتفسير النتائج وكيفية تجنبها. بالإضافة إلى ذلك ، يمكننا أن نفسر كيف يتم تقييم السلوكيات التي تتجلى في الاختبار.

Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

The Mouse Forced Swim Test

التحقق من صحة الاختبار القسري السباحة كنهج تجريبية لتقييم فعالية مضادات الاكتئاب المحتملة في القوارض. توضع حيوانات التجارب في خزان للمياه والهروب السلوك المتصل التنقل هو كميا. ووصف إجراءات مشتركة لإصدار الماوس من هذا الاختبار.

اختبار ماوس القسري السباحة

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Research

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Neuroscience

One Dimensional Turing-Like Handshake Test for Motor Intelligence

أحد الأبعاد اختبار تورينج المصافحة على غرار سيارات للاستخبارات

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متعددة الماوس تشريحي عصبي التصوير بالرنين المغناطيسي

The field of mouse phenotyping with magnetic resonance imaging (MRI) is rapidly growing, motivated by the need for improved tools for characterizing and ...

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الكشف عن لوحات لالتهاب الأعصاب في مرض ألزهايمر النموذجي ماوس

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Forced alternation and left-right discrimination tasks using the T-maze have been widely used to assess working and reference memory, respectively, in ...

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Detection and primary processing of physical, chemical and thermal sensory stimuli by peripheral sensory nerve fibers is key to sensory perception in ...

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اختبار الذيل تعليق

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that ...

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

تسريب التجسيمي من بلازميدة قليلة القسيمات اميلويد بيتا في الحصين ماوس

Alzheimer&#8217;s disease is a neurodegenerative disease affecting the aging population. A key neuropathological feature of the disease is the ...

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Automated Analysis of C. elegans Swim Behavior Using CeleST Software

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تحليل الآلي لل<em&gt; C. ايليجانس</em&gt; السباحة السلوك باستخدام CeleST البرمجيات

Dissecting the neuronal and neuromuscular circuits that regulate behavior remains a major challenge in biology. The nematode Caenorhabditis elegans has ...

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

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The capillary refill test was introduced in 1947 to help estimate circulatory status in critically ill patients. Guidelines commonly state that refill ...