Name: the mouse forced swim test
Uploaded: 2012-01-29T14:00:00
Description: Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

这项研究已被授予NIHM MH091816 R01和R21的MH084043到TDG支持。

1。材料与方法 1.1。水箱 （30厘米高x 20厘米直径）的圆柱型坦克所需的小鼠强迫游泳实验（FST）的在我们的实验室，是透明的有机玻璃建造，这种材料能够承受的坦克和事故比玻璃更好的频繁流动。从底部水位15厘米，并应标明坦克，以确保水的体积是在小鼠一致。理想情况下，坦克的数量应该至少两次一次测试小鼠的数量很多，而第一套使用的是第二个水?...

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FST的（有时也被称为Porsolt游泳测试）是开发的第一对大鼠，小鼠Porsolt和同事 12,13，然后修改。除了 ​​上述的协议，在我们的实验室中成功，主要是微妙的测试修改已公布（见Hascoët和Bourin 为一个完整的审查1）。它是一种常见的测试，使用的抗抑郁药物和各种行为和神经生物学基础和临床研究3,14-16操作的影响疗效评价。它被形容为渲染“行为绝望”是诱导情况，即动?...

<ul><li>水箱</li><li>温度计</li><li>定时器</li><li>摄像机</li><li>白噪声发生器（可选） </li><li>干燥纸</li></ul>

the mouse forced swim test

强迫游泳试验是一种啮齿动物行为学测试，用于评价抗抑郁药物，抗抑郁疗效的新化合物，实验操作，目的是在渲染或防止国家像抑郁。小鼠被放置在透明水箱，装满水，并测量其逃避有关流动性的行为是负有不可推卸的。强迫游泳测试是直接进行可靠的，它需要最少的专用设备。强迫游泳试验的成功实施需要遵守一定的程序细节，并尽量减少不必要的压力的老鼠。在协议的描述和影随行中，我们解释了如何进行鼠标本次测试的版本，强调对潜在的隐患，可能危害结果的解释，以及如何避免它们。此外，我们解释了如何在测试中表现出来的行为评估。

Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

The Mouse Forced Swim Test

强迫游泳测试是在啮齿类动物实验的方法来评估潜在的抗抑郁疗效验证。实验动物被放置在一缸水和逃避相关的流动性行为，量化。共同的这个测试鼠标版的程序进行了阐述。

小鼠强迫游泳实验

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Research

JoVE Journal

Neuroscience

One Dimensional Turing-Like Handshake Test for Motor Intelligence

一维类似图灵汽车情报握手测试

In the Turing test, a computer model is deemed to "think intelligently" if it can generate answers that are not distinguishable from those of a human.  ...

科研

神经科学

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

多鼠神经解剖学磁共振成像

The field of mouse phenotyping with magnetic resonance imaging (MRI) is rapidly growing, motivated by the need for improved tools for characterizing and ...

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

在阿尔茨海默氏症小鼠模型神经炎斑检测

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia. Neuritic plaque formation is one of the pathological hallmarks ...

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-迷宫强迫交替和评估工作，并参考在小鼠记忆的左，右的歧视任务

Forced alternation and left-right discrimination tasks using the T-maze have been widely used to assess working and reference memory, respectively, in ...

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones

鼠标感觉神经支配的皮肤和四肢骨骼纤维组织的制备及免疫染色

Detection and primary processing of physical, chemical and thermal sensory stimuli by peripheral sensory nerve fibers is key to sensory perception in ...

The Tail Suspension Test

悬尾实验

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that ...

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

低聚淀粉样蛋白-β的立体灌注到小鼠海马

Alzheimer&#8217;s disease is a neurodegenerative disease affecting the aging population. A key neuropathological feature of the disease is the ...

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions

腓神经损伤方法：可靠检测，以确定和测试因素修复神经肌肉接头

The neuromuscular junction (NMJ) undergoes deleterious structural and functional changes as a result of aging, injury and disease. Thus, it is imperative ...

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

的自动分析<em&gt;℃。线虫</em&gt;游泳行为使用天书软件

Dissecting the neuronal and neuromuscular circuits that regulate behavior remains a major challenge in biology. The nematode Caenorhabditis elegans has ...

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

漫反射光谱分析: 在拇指下进行毛细管填充试验

The capillary refill test was introduced in 1947 to help estimate circulatory status in critically ill patients. Guidelines commonly state that refill ...