Name: the mouse forced swim test
Uploaded: 2012-01-29T14:00:00
Description: Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

이 연구는 부여 NIHM R01 MH091816과 TDG에 R21 MH084043에 의해 지원되었습니다.

1. 재료 및 방법 1.1. 물 탱크 이 자료는 유리보다 탱크와 사고의 빈번한 움직임을 견딜 수있는 같은 원통형 탱크 (30cm 높이 X 20cm의 직경)은 투명한 플렉시의 건설에 우리 연구실에서 마우스 강제 수영 시험 (FST)을 위해 필요합니다. 수위가 바닥에서 15cm이며, 물의 볼륨이 생쥐에 걸쳐 일관성이 있는지 확인하기 위해 탱크에 표시된해야합니다. 탱크의 수는적으...

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FST는 (때로는 Porsolt 수영 테스트라고도 함) 쥐에 대한 첫번째 개발하고 Porsolt 및 동료 12,13으로 마우스에 대한 바뀌었습니다. 저희 연구실에서 성공 위에서 설명한 프로토콜 이외에, 대부분 섬세한 테스트 수정의 번호 (완전한 검토 1 Hascoët 및 Bourin 참조) 출판되었습니다. 그것은 안티 - depressant, 마약, 그리고 기본 및 잠복기 연구 3,14-16의 다양한 행동 및 신경 생물학 조작의...

the mouse forced swim test

강제 수영 시험 약은 의약품, 새로운 화합물의 약은 효능, 그리고 미국과 같은 우울증을 렌더링하거나 예방하기위한 아르 실험 조작의 평가에 사용되는 쥐 행동 테스트입니다. 마우스는 물로 가득 차 있으며, 그들의 탈출 관련 이동성 행동 측정 피할 투명한 수조에 배치됩니다. 강제 수영 시험은 안정적으로 수행할 수 있도록 간단하고 최소한의 전문적인 장비를 필요로합니다. 강제 수영 시험의 성공적인 구현은 생쥐에게 부당한 스트레스의 특정 절차 내용 및 최소화하기 위해 준수해야합니다. 프로토콜 설명과 함께 동영상에서 우리는 어떻게 그들을 피하기 위해 결과의 해석 및 저해 될 수있는 잠재적인 함정에 중점이 시험의 마우스 버전을 수행하는 방법에 대해 설명합니다. 또한, 우리는 시험에 나타나신 행동이 평가 방법에 대해 설명합니다.

Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

The Mouse Forced Swim Test

강제 수영 시험은 설치류 동물의 잠재적인 약은 효험을 평가하기위한 실험 방법으로 확인됩니다. 실험 동물은 물과 탈출 관련 이동성 행동의 탱크에 배치됩니다 계량입니다. 이 테스트의 마우스 버전에 대한 일반적인 절차가 설명되어 있습니다.

마우스 강제 수영 시험

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Research

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Neuroscience

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