Name: the mouse forced swim test
Uploaded: 2012-01-29T14:00:00
Description: Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

Это исследование было поддержано грантом NIHM R01 и R21 MH091816 MH084043 к ПОГ.

1. Материалы и методы 1.1. Емкости для воды Цилиндрических резервуаров (30 см высота х 20 см диаметром), необходимые для мыши вынуждены плавать тест (ФСТ) в нашей лаборатории изготавливаются из прозрачного оргстекла, так как этот материал способен выдерживать ча?...

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ФСТ (иногда называемый тест Porsolt плавать) был разработан первый для крыс, а затем модифицирован для мышей Porsolt и коллеги 12,13. В дополнение к описанным выше протокол успешных в нашей лаборатории, число в значительной степени тонкие модификации теста были опубликованы (см. Hascoët и Bourin ?...

<ul><li> Емкости для воды </li><li> Термометр </li><li> Таймер </li><li> Видеокамера </li><li> White Noise Generator (опционально) </li><li> Сушка бумаги </li></ul>

the mouse forced swim test

Вынуждены плавать тест грызунов поведенческих тест, используемый для оценки антидепрессантов, антидепрессанты эффективности новых соединений и экспериментальных манипуляций, направленных на оказание или предотвращения депрессивных состояниях. Мыши находятся в неизбежной прозрачной танк, который заполняется водой, и их выход на поведение в отношении мобильности измеряется. Вынуждены плавать тест прост для проведения надежно и с минимальными требованиями к специализированным оборудованием. Успешная реализация вынуждены плавать тест требует соблюдения определенных процедурных деталей и минимизации необоснованного стресс для мышей. В описании протокола и сопровождающие видео, мы объясняем, как вести мышь версия этого теста с акцентом на потенциальные проблемы, которые могут иметь пагубные последствия для интерпретации результатов и как их избежать. Кроме того, мы объясняем, как поведение проявляется в тесте оценивается.

Watch this Scientific Journal Video about The Mouse Forced Swim Test at JoVE.com

The Mouse Forced Swim Test

Вынуждены плавать тест проверяется как экспериментальный подход к оценке потенциальных антидепрессантами эффективность у грызунов. Экспериментальные животные помещаются в резервуар с водой и избежать поведения, связанного мобильность количественно. Общих процедур для мыши версия этого теста описаны.

Мышь принудительного плавания испытаний

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Research

JoVE Journal

Neuroscience

One Dimensional Turing-Like Handshake Test for Motor Intelligence

Одномерных Тьюринга-Like Рукопожатие Тест для двигателя разведки

In the Turing test, a computer model is deemed to "think intelligently" if it can generate answers that are not distinguishable from those of a human.  ...

Multiple-mouse Neuroanatomical Magnetic Resonance Imaging

Несколько мыши нейроанатомической Магнитно-резонансная томография

The field of mouse phenotyping with magnetic resonance imaging (MRI) is rapidly growing, motivated by the need for improved tools for characterizing and ...

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

Обнаружение Neuritic бляшки при болезни Модель мыши Альцгеймера

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia. Neuritic plaque formation is one of the pathological hallmarks ...

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

T-лабиринту Принудительное чередование и влево-вправо дискриминации Задачи для оценки рабочей и обращение к памяти у мышей

Forced alternation and left-right discrimination tasks using the T-maze have been widely used to assess working and reference memory, respectively, in ...

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones

Подготовка тканей и Иммуноокрашивание Мыши чувствительные нервные волокна, иннервирующие кожу и кости конечностей

Detection and primary processing of physical, chemical and thermal sensory stimuli by peripheral sensory nerve fibers is key to sensory perception in ...

The Tail Suspension Test

Испытание Хвост подвеска

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that ...

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Стереотаксическая Настой олигомерных бета-амилоида в гиппокампе мыши

Alzheimer&#8217;s disease is a neurodegenerative disease affecting the aging population. A key neuropathological feature of the disease is the ...

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions

Малоберцового нерва Метод Травма: Надежный Анализ для идентификации и испытания факторов, которые Ремонт нервно-мышечных синапсах

The neuromuscular junction (NMJ) undergoes deleterious structural and functional changes as a result of aging, injury and disease. Thus, it is imperative ...

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Automated Analysis of C. elegans Swim Behavior Using CeleST Software

Автоматизированный анализ<em&gt; C. Элеганс</em&gt; Плавать Поведение Использование CELEST программного обеспечения

Dissecting the neuronal and neuromuscular circuits that regulate behavior remains a major challenge in biology. The nematode Caenorhabditis elegans has ...

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

Спектроскопия диффузного отражения: Получение капиллярного пополнения тест под один палец

The capillary refill test was introduced in 1947 to help estimate circulatory status in critically ill patients. Guidelines commonly state that refill ...