Name: the tail suspension test
Uploaded: 2012-01-28T21:00:00
Description: Watch this Scientific Journal Video about The Tail Suspension Test at JoVE.com

وقد تم دعم هذه الدراسة من منحة NIHM R01 R21 MH091816 وMH084043 إلى TDG.

1. المواد 1. تعليق مربع اختبار تعليق الذيل (تجارة الرقيق عبر الأطلسي) ، تتضمن تعليق الفئران فوق سطح الأرض عن طريق ذيولها. على أبسط المستويات ، فإن الإجراء لا يتطلب سوى تعليق أو شريط الحافة الرف ، وا...

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تطوير تجارة الرقيق عبر الأطلسي التي Steru آخرون تأثر 9 من الاختبار التي سبق وضعها السباحة القسري 10-12. يتم وضع مماثل لاختبار السباحة القسري ، وتجارة الرقيق عبر الأطلسي في الفئران في وضع لا مفر منه ولكن باعتدال المجهدة. ويعتبر عدم وجود سلوك الهروب المتعلق?...

<ul style=";text-align:right;direction:rtl"><li style=";text-align:right;direction:rtl"> شريط </li><li style=";text-align:right;direction:rtl"> مؤقت </li><li style=";text-align:right;direction:rtl"> كاميرا فيديو </li><li style=";text-align:right;direction:rtl"> مولدات الضوضاء البيضاء (اختياري) </li><li style=";text-align:right;direction:rtl"> Climbstoppers (اختياري ؛ تبعا لسلالة المستخدمة) </li></ul>

the tail suspension test

اختبار تعليق الذيل هو اختبار الماوس سلوكية مفيدة في فحص العقاقير المضادة للاكتئاب المحتملة ، وتقييم التلاعب الأخرى التي يتوقع أن تؤثر على الكآبة السلوكيات ذات الصلة. وعلقت الفئران التي ذيولها مع الشريط ، في مثل هذا الموقف أنه لا يستطيع الهرب او الابقاء على الأسطح المجاورة. خلال هذا الاختبار ، وعادة في مدة ست دقائق ، وكميا السلوكيات الناتجة الهروب المنحى. اختبار تعليق الذيل هو أداة قيمة في اكتشاف دواء لسرعة عالية من المركبات المضادة للاكتئاب الفرز المحتملين. هنا ، نحن تصف التفاصيل المطلوبة لتنفيذ هذا الاختبار إضافية مع التركيز على المشاكل المحتملة التي قد تحدث وكيفية تجنبها. كما نقدم حلا لسلوك الذيل التسلق ، وهي مشكلة مشتركة ، الأمر الذي يجعل هذا الاختبار غير مجدية في بعض سلالات الفأر ، مثل استخدام على نطاق واسع C57BL / 6. على وجه التحديد ، فإننا منع تسلق الذيل السلوكيات عن طريق تمرير الماوس من خلال ذيول بلاستيكية صغيرةاسطوانة قبل التعليق. أخيرا ، فإننا بالتفصيل كيفية تسجيل يدويا السلوكيات التي تتجلى في هذا الاختبار.

Watch this Scientific Journal Video about The Tail Suspension Test at JoVE.com

The Tail Suspension Test

التحقق من صحة اختبار الذيل التعليق كإجراء تجريبي لتقييم نجاعة العلاج بالعقاقير المضادة للاكتئاب من في الفئران. وعلقت الفئران التي ذيولها لمدة ست دقائق ، ويتم تقييم الهروب السلوكيات ذات الصلة. نحن تصف الإجراءات المستخدمة في إجراء اختبار تعليق الذيل.

اختبار الذيل تعليق

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that ...

Research

JoVE Journal

Neuroscience

One Dimensional Turing-Like Handshake Test for Motor Intelligence

أحد الأبعاد اختبار تورينج المصافحة على غرار سيارات للاستخبارات

In the Turing test, a computer model is deemed to "think intelligently" if it can generate answers that are not distinguishable from those of a human.  ...

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer&#39;s Disease Model Mice

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

اختبار متاهة موريس المائية للعجز التعلم والذاكرة في الفئران مرض الزهايمر النموذجي

The Morris Water Maze (MWM) was first established by neuroscientist Richard G. Morris in 1981 in order to test hippocampal-dependent learning, including ...

The Mouse Forced Swim Test

اختبار ماوس القسري السباحة

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

حلقة مغلقة العصبية الروبوتية تجارب لاختبار خصائص الحاسوبية من الشبكات العصبية

Information coding in the Central Nervous System (CNS) remains unexplored. There is mounting evidence that, even at a very low level, the representation ...

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions

العصب الشظية الإصابات الطريقة: مقايسة موثوقة لتحديد واختبار العوامل التي إصلاح العضلية المفارق

The neuromuscular junction (NMJ) undergoes deleterious structural and functional changes as a result of aging, injury and disease. Thus, it is imperative ...

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

بطارية اختبار محوسبة لدراسة تأثيرات ميكروبيولوجية على الجهاز العصبي المركزي المخدرات اتروبين في المرحلة المبكرة من تطوير العقاقير

Investigating potential pharmacodynamic effects in an early phase of central nervous system (CNS) drug research can provide valuable information for ...

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

منتشر الانعكاس الطيفي: الحصول على اختبار الملء الشعرية تحت الإبهام واحد

The capillary refill test was introduced in 1947 to help estimate circulatory status in critically ill patients. Guidelines commonly state that refill ...

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

إجراء اختبار موضوعي واستنساخه من التعلم حاسة الشم والتمييز في الفئران

Olfaction is the predominant sensory modality in mice and influences many important behaviors, including foraging, predator detection, mating, and ...

Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion

كثرة أخذ عينات الدم الذيل-نصيحة في الفئران للتقييم لإفراز الهرمون نابض

In many endocrine systems, circulating factors or hormones are not released continuously, but are secreted as a discrete pulse in response to a releasing ...

A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury

اختبار متري لتقييم الذاكرة العاملة المكانية في الفئران البالغة بعد إصابة الدماغ الرضية

Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due to the ethical limitations of ...