Name: the tail suspension test
Uploaded: 2012-01-28T21:00:00
Description: Watch this Scientific Journal Video about The Tail Suspension Test at JoVE.com

이 연구는 부여 NIHM R01 MH091816과 TDG에 R21 MH084043에 의해 지원되었습니다.

1. 자료 1. 서스펜션 상자 꼬리 - 서스펜션 테스트 (TST)는 자신의 꼬리로 지상 정지 쥐를을 포함한다. 가장 기본적인 수준에서 프로 시저는 서스펜션 바 또는 진열 선반, 그리고 테이프가 필요합니다. 그러나 실험자 최적의 명암을 제공하는 배경의 사용을 고려해야합니다. 또한, 그것은 테스트중인 다른 동물을 관찰에서 마우스를 방지하기 위해 조치를 취할 ?...

<ol>
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Behav. 70, 187-192 (2001).</li><li>Cervo, L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Genotype-dependent+activity+of+tryptophan+hydroxylase-2+determines+the+response+to+citalopram+in+a+mouse+model+of+depression.">Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.</a> J. Neurosci. 25, 8165-8172 (2005).</li><li>David, D. J., Renard, C. E., Jolliet, P., Hascoet, M., Bourin, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Antidepressant-like+effects+in+various+mice+strains+in+the+forced+swimming+test.">Antidepressant-like effects in various mice strains in the forced swimming test.</a> Psychopharmacology (Berl). 166, 373-382 (2003).</li><li>Dulawa, S. C., Holick, K. 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A., Hen, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Mood and Anxiety related phenotypes in mice: Characterization using behavioral tests. 63, 107-121 (2011).</li><li>Juszczak, G. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+usage+of+video+analysis+system+for+detection+of+immobility+in+the+tail+suspension+test+in+mice.">The usage of video analysis system for detection of immobility in the tail suspension test in mice.</a> Pharmacology Biochemistry and Behavior. 85, 332-338 (2006).</li><li>Crowley, J. J., Jones, O. '. 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Steru 외 의해 TST의 개발. 9 이전에 개발된 강제 수영 시험 10-12 영향을 받았습니다. TST 생쥐의 강제 수영 테스트와 마찬가지로이 피할 수 있지만 적당히 스트레스 상황에 배치됩니다. 탈출과 관련된 행동의 부족은 부동 간주됩니다. 강제 수영 시험과 마찬가지로, TST는 최고의 마약 약은 효능 평가를위한 검증 시험입니다,뿐만 아니라 환경, 신경 생물학 및 유전자 조작 <...

<ul><li> 테이프 </li><li> 타이머 </li><li> 비디오 카메라 </li><li> 화이트 노이즈 생성기 (옵션) </li><li> Climbstoppers (옵션, 변형이 사용에 따라) </li></ul>

the tail suspension test

꼬리 - 서스펜션 테스트는 잠재적인 약은 약물 검사에 유용 마우스 동작 테스트하고, 우울증과 관련된 행동에 영향을 미칠 것으로 예상되는 다른 조작의 평가. 생쥐가 탈출하거나 가까운 표면에 물을 수 없습니다 것과 같은 위치에, 테이프 자신의 꼬리에 의해 중지됩니다. 이 테스트가 진행되는 동안, 일반적으로 기간이 여섯 분, 결과 지향적인 탈출 동작 계량입니다. 꼬리 - 서스펜션 테스트 예비 약은 화합물의 높은 처리량 검사를위한 약물 발견에 유용한 도구입니다. 여기, 우리가 발생할 수 있으며이를 방지하는 방법 잠재적인 문제에 대한 자세한 중심으로이 테스트의 구현에 필요한 세부 정보를 설명합니다. 우리는 또한 널리 사용되는 C57BL / 6로 꼬리 등산 문제에 대한 해결책, 일부 마우스 변종이 테스트 쓸모없는 렌더링 일반적인 문제를 제공합니다. 특히, 우리는 작은 플라스틱을 통해 마우스 꼬리를 통과하여 꼬리 등반 행위를 방지이전 중지 실린더. 마지막으로, 우리는 자세히 어떻게 수동으로 테스트에 나타나신있는 동작을 점수.

Watch this Scientific Journal Video about The Tail Suspension Test at JoVE.com

The Tail Suspension Test

꼬리 - 서스펜션 시험은 마우스에서 약물 치료의 약은 효능을 평가하기위한 실험 절차로 검증됩니다. 생쥐 6 분 동안 자신의 꼬리에 의해 중단되고 탈출 관련 동작이 평가됩니다. 우리는 꼬리 정지 테스트를 수행에 사용되는 절차를 설명합니다.

꼬리 서스펜션 테스트

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that ...

Research

JoVE Journal

Neuroscience

One Dimensional Turing-Like Handshake Test for Motor Intelligence

자동차 인텔리 전스에 대한 1 차원 튜링 - 마찬가지로 악수 시험

In the Turing test, a computer model is deemed to "think intelligently" if it can generate answers that are not distinguishable from those of a human.  ...

연구

신경과학

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer&#39;s Disease Model Mice

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

알츠하이머병 모델 마우스에서 학습 및 메모리 적자에 대한 모리스 워터 메이즈 테스트

The Morris Water Maze (MWM) was first established by neuroscientist Richard G. Morris in 1981 in order to test hippocampal-dependent learning, including ...

The Mouse Forced Swim Test

마우스 강제 수영 시험

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental ...

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

폐쇄 루프 신경 로봇 실험은 신경 네트워크의 전산 등록을 테스트하는

Information coding in the Central Nervous System (CNS) remains unexplored. There is mounting evidence that, even at a very low level, the representation ...

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions

비골 신경 손상 방법 : 신뢰할 수있는 분석은 확인하고 테스트 즉, 수리 신경 근육 학 접합 요인

The neuromuscular junction (NMJ) undergoes deleterious structural and functional changes as a result of aging, injury and disease. Thus, it is imperative ...

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Investigating potential pharmacodynamic effects in an early phase of central nervous system (CNS) drug research can provide valuable information for ...

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

확산 반사율 분광학: 점점 하나의 엄지손가락 아래 모 세관 보충물 테스트

The capillary refill test was introduced in 1947 to help estimate circulatory status in critically ill patients. Guidelines commonly state that refill ...

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

후 각 학습 및 쥐에 있는 차별의 객관적이 고 재현성 시험

Olfaction is the predominant sensory modality in mice and influences many important behaviors, including foraging, predator detection, mating, and ...

Frequent Tail-tip Blood Sampling in Mice for the Assessment of Pulsatile Luteinizing Hormone Secretion

타악기 황 호르몬 분 비의 평가 대 한 쥐에서 꼬리 팁 혈액 샘플링을 자주

In many endocrine systems, circulating factors or hormones are not released continuously, but are secreted as a discrete pulse in response to a releasing ...

A Metric Test for Assessing Spatial Working Memory in Adult Rats Following Traumatic Brain Injury

외상성 뇌 손상 다음 성인 쥐에서 공간 작업 메모리를 평가 하기 위한 메트릭 테스트

Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due to the ethical limitations of ...