Name: quantification of atherosclerotic plaque activity and vascular inflammation using [18-f] fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct)
Uploaded: 2012-05-02T13:00:00
Description: Watch this Scientific Journal Video about Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography F

NNM支持拨款从国家牛皮癣基金会，的NHLBI 5K23HL97151-3和HL111293。 ，JMG是支持由NHLBI以R01 HL089744和以R01 HL111293。

1。病人的制备及获取图像<ol><li>固定的PET / CT扫描仪至少一个小时的成像时间槽，最好用飞行时间，提高图像质量的能力之一。在我们的机构，我们使用双子座TF扫描仪，这是最新的PET / CT系统，飞利浦医疗系统，并结合在PET扫描仪与华晨16层CT系统对溶菌酶探测器的基础。 </li><li>有科目快8小时前FDG-PET/CT扫描。检查空腹血清葡萄糖（FSG）的水平，用指尖，以保证血糖&lt;200 mg / dL的葡萄糖管理之前...

<ol>
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K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Site+of+intimal+rupture+or+erosion+of+thrombosed+coronary+atherosclerotic+plaques+is+characterized+by+an+inflammatory+process+irrespective+of+the+dominant+plaque+morphology.">Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.</a> Circulation. 89, 36-44 (1994).</li><li>van der Wal, A. C., Becker, A. E., van der Loos, C. M., Tigges, A. J., Das, P. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fibrous+and+lipid-rich+atherosclerotic+plaques+are+part+of+interchangeable+morphologies+related+to+inflammation:+a+concept.">Fibrous and lipid-rich atherosclerotic plaques are part of interchangeable morphologies related to inflammation: a concept.</a> Coron. Artery Dis. 5, 463-469 (1994).</li><li>Alavi, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Positron+emission+tomography+imaging+of+regional+cerebral+glucose+metabolism.">Positron emission tomography imaging of regional cerebral glucose metabolism.</a> Semin. Nucl. Med. 16, 2-34 (1986).</li><li>Hustinx, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dual+time+point+fluorine-18+fluorodeoxyglucose+positron+emission+tomography:+a+potential+method+to+differentiate+malignancy+from+inflammation+and+normal+tissue+in+the+head+and+neck.">Dual time point fluorine-18 fluorodeoxyglucose positron emission tomography: a potential method to differentiate malignancy from inflammation and normal tissue in the head and neck.</a> Eur. J. Nucl. Med. 26, 1345-1348 (1999).</li><li>Ogawa, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=(18)F-FDG+accumulation+in+atherosclerotic+plaques:+immunohistochemical+and+PET+imaging+study.">(18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.</a> J. Nucl. Med. 45, 1245-1250 ( ).</li><li>Yun, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=F-18+FDG+uptake+in+the+large+arteries:+a+new+observation.">F-18 FDG uptake in the large arteries: a new observation.</a> Clin. Nucl. Med. 26, 314-319 (2001).</li><li>Mehta, N. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Systemic+and+Vascular+Inflammation+in+Patients+With+Moderate+to+Severe+Psoriasis+as+Measured+by+[18F]-Fluorodeoxyglucose+Positron+Emission+Tomography-Computed+Tomography+(FDG-PET/CT):+A+Pilot+Study.">Systemic and Vascular Inflammation in Patients With Moderate to Severe Psoriasis as Measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG-PET/CT): A Pilot Study.</a> Arch. Dermatol. , .</li><li>Davies, J. 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Imaging. 35, 562-569 (2008).</li><li>Arauz, A., Hoyos, L., Zenteno, M., Mendoza, R., Alexanderson, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Carotid+plaque+inflammation+detected+by+18F-fluorodeoxyglucose-positron+emission+tomography.+Pilot+study.">Carotid plaque inflammation detected by 18F-fluorodeoxyglucose-positron emission tomography. Pilot study.</a> Clin. Neurol. Neurosurg. 109, 409-412 (2007).</li><li>Rominger, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=18F-FDG+PET/CT+identifies+patients+at+risk+for+future+vascular+events+in+an+otherwise+asymptomatic+cohort+with+neoplastic+disease.">18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease.</a> J. Nucl. Med. 50, 1611-1620 (2009).</li><li>Wasselius, J. A., Larsson, S. A., Jacobsson, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-accumulating+atherosclerotic+plaques+identified+with+18F-FDG-PET/CT+in+141+patients.">FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients.</a> Mol. Imaging Biol. 11, 455-459 (2009).</li><li>Tahara, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simvastatin+attenuates+plaque+inflammation:+evaluation+by+fluorodeoxyglucose+positron+emission+tomography.">Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography.</a> J. Am. Coll. Cardiol. 48, 1825-1831 (2006).</li><li>Lee, S. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reversal+of+vascular+18F-FDG+uptake+with+plasma+high-density+lipoprotein+elevation+by+atherogenic+risk+reduction.">Reversal of vascular 18F-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction.</a> J. Nucl. Med. 49, 1277-1282 (2008).</li><li>Rudd, J. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=(18)Fluorodeoxyglucose+positron+emission+tomography+imaging+of+atherosclerotic+plaque+inflammation+is+highly+reproducible:+implications+for+atherosclerosis+therapy+trials.">(18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials.</a> J. Am. Coll. Cardiol. 50, 892-896 ( ).</li><li>Bural, G. 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这里介绍的方法是直接执行，并能产生有用信息，对动脉粥样硬化斑块的活动和血管炎症，在临床上显着的动脉床。这种分析方法有一些值得重视的重要功能：1）我们使用高品质的PET / CT扫描仪，其中有16个探测器行和飞行时间的能力; 2）我们利用两个失明的临床资料，以经验丰富的观察员进行测量，以确保量化数据的一致性; 3）我们同时描述四个量化的成果，这是每一个信息。我们建议至少动?...

<table border="1"><tbody><tr><td> 设备名称 </td><td> 公司 </td></tr><tr><td>双子座的TF PET / CT扫描仪</td><td>飞利浦医疗保健</td></tr><tr><td>扩展华晨工作站</td><td>飞利浦医疗保健</td></tr></tbody></table>

quantification of atherosclerotic plaque activity and vascular inflammation using [18-f] fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct)

传统的非侵入性动脉粥样硬化的成像方式，如冠状动脉钙化（CAC）和颈动脉内膜中层厚度（IMT）的2提供有关的疾病负担。然而，尽管3-5成飞，和C-IMT的2,6多个验证研究，这些方式都无法准确评估斑块的特点7,8，和斑块的组成和炎症状态决定了其稳定性，因此，风险9-13临床事件。 [18 F]，2 -氟-2 -脱氧-D-葡萄糖（葡萄糖）利用正电子发射断层扫描（PET）/电脑断层扫描（CT）的影像已被广泛研究在肿瘤学代谢14,15。在人类使用的动物模型和免疫组化的研究表明，FDG-PET/CT是精美的敏感检测巨噬细胞活性，细胞在血管壁炎症的重要来源。莫重新最近，我们17,18和其他人已经表明，FDG-PET/CT使高度精确，在9,16,19,20大型和中型动脉粥样硬化斑块的活动抗炎活性的新型测量。 FDG-PET/CT研究具有比其他成像方式的许多优点：1）高对比度的决议; 2）斑块体积的定量和代谢活性允许多式联运动脉粥样硬化斑块的定量; 3）动态，实时， 体内成像; 4）最小的运营商的依赖。最后，血管炎症FDG-PET/CT检测已被证明预测心血管（CV）事件独立于传统的危险因素，21,22和23动脉粥样硬化的总体负担也高度相关。的牌匾FDG-PET/CT活动调制知名有益的简历干预措施，如短期（12周）他汀类药物治疗24以及长远的治疗性生活方式改变（16月）25。 </P&gt; 目前在动脉粥样硬化斑块的FDG摄取的量化方法涉及测量，以计算目标背景比（TBR的），这是除以计算标准化摄取值（SUV）的利益动脉和静脉血泊由动脉静脉血泊SUV越野车。表明该方法稳定，重复性型代表随着时间的推移，具有灵敏度高，检测血管炎症，也有高间内读者可靠性26。在这里，我们提出我们的方法为患者准备，图像采集，量化使用的SUV，TBR，一个全球性的参数，动脉粥样硬化斑块的活动和血管炎症，称为代谢体积产品（MVP）。这些方法可应用于各种利益一致的方式研究样本，以评估血管炎症，因为我们已经在多个以前的出版物中。9,20,27,28 &lt;/ SUP&gt;

Watch this Scientific Journal Video about Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography F

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

有很大的需要，以确定动脉粥样硬化的非侵入性，在这里，我们演示了如何FDG-PET/CT可用于检测和量化动脉粥样硬化斑块的活动和血管炎症。

动脉粥样硬化斑块的活动和血管炎症的定量使用[18 F]，氟正电子发射断层扫描/电脑断层扫描（FDG-PET/CT）

Conventional non-invasive imaging modalities of atherosclerosis such as coronary artery calcium (CAC)1 and carotid intimal medial thickness (C-IMT)2 ...

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Medicine

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

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