Name: quantification of atherosclerotic plaque activity and vascular inflammation using [18-f] fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct)
Uploaded: 2012-05-02T13:00:00
Description: Watch this Scientific Journal Video about Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography F

NNMは、国立乾癬財団、NHLBI 5K23HL97151-3とHL111293からの助成金によってサポートされています。 JMGは、NHLBI R01 HL089744とR01 HL111293でサポートされています。

1。患者の準備と取得画像<ol><li>画質向上のための飛行時間型機能を備え、好ましくは、1、PET / CTスキャナ上の少なくとも1つの時間イメージングタイムスロットを固定します。当院では、フィリップスメディカルシステムズから最新のPET / CTシステムで、16スライスCTブリリアンスシステムとリゾ検出器に基づくPETスキャナを組み合わせたジェミニTFスキャナを使用しています。 </li><li> FDG-PET/...

<ol>
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Med. 16, 2-34 (1986).</li><li>Hustinx, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dual+time+point+fluorine-18+fluorodeoxyglucose+positron+emission+tomography:+a+potential+method+to+differentiate+malignancy+from+inflammation+and+normal+tissue+in+the+head+and+neck.">Dual time point fluorine-18 fluorodeoxyglucose positron emission tomography: a potential method to differentiate malignancy from inflammation and normal tissue in the head and neck.</a> Eur. J. Nucl. Med. 26, 1345-1348 (1999).</li><li>Ogawa, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=(18)F-FDG+accumulation+in+atherosclerotic+plaques:+immunohistochemical+and+PET+imaging+study.">(18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.</a> J. Nucl. Med. 45, 1245-1250 ( ).</li><li>Yun, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=F-18+FDG+uptake+in+the+large+arteries:+a+new+observation.">F-18 FDG uptake in the large arteries: a new observation.</a> Clin. Nucl. Med. 26, 314-319 (2001).</li><li>Mehta, N. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Systemic+and+Vascular+Inflammation+in+Patients+With+Moderate+to+Severe+Psoriasis+as+Measured+by+[18F]-Fluorodeoxyglucose+Positron+Emission+Tomography-Computed+Tomography+(FDG-PET/CT):+A+Pilot+Study.">Systemic and Vascular Inflammation in Patients With Moderate to Severe Psoriasis as Measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG-PET/CT): A Pilot Study.</a> Arch. Dermatol. , .</li><li>Davies, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-PET+can+distinguish+inflamed+from+non-inflamed+plaque+in+an+animal+model+of+atherosclerosis.">FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.</a> Int. J. Cardiovasc. Imaging. 26, 41-48 (2011).</li><li>Bural, G. G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-PET+is+an+effective+imaging+modality+to+detect+and+quantify+age-related+atherosclerosis+in+large+arteries.">FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries.</a> Eur. J. Nucl. Med. Mol. Imaging. 35, 562-569 (2008).</li><li>Arauz, A., Hoyos, L., Zenteno, M., Mendoza, R., Alexanderson, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Carotid+plaque+inflammation+detected+by+18F-fluorodeoxyglucose-positron+emission+tomography.+Pilot+study.">Carotid plaque inflammation detected by 18F-fluorodeoxyglucose-positron emission tomography. Pilot study.</a> Clin. Neurol. Neurosurg. 109, 409-412 (2007).</li><li>Rominger, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=18F-FDG+PET/CT+identifies+patients+at+risk+for+future+vascular+events+in+an+otherwise+asymptomatic+cohort+with+neoplastic+disease.">18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease.</a> J. Nucl. Med. 50, 1611-1620 (2009).</li><li>Wasselius, J. A., Larsson, S. A., Jacobsson, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=FDG-accumulating+atherosclerotic+plaques+identified+with+18F-FDG-PET/CT+in+141+patients.">FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients.</a> Mol. Imaging Biol. 11, 455-459 (2009).</li><li>Tahara, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simvastatin+attenuates+plaque+inflammation:+evaluation+by+fluorodeoxyglucose+positron+emission+tomography.">Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography.</a> J. Am. Coll. Cardiol. 48, 1825-1831 (2006).</li><li>Lee, S. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reversal+of+vascular+18F-FDG+uptake+with+plasma+high-density+lipoprotein+elevation+by+atherogenic+risk+reduction.">Reversal of vascular 18F-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction.</a> J. Nucl. Med. 49, 1277-1282 (2008).</li><li>Rudd, J. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=(18)Fluorodeoxyglucose+positron+emission+tomography+imaging+of+atherosclerotic+plaque+inflammation+is+highly+reproducible:+implications+for+atherosclerosis+therapy+trials.">(18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials.</a> J. Am. Coll. Cardiol. 50, 892-896 ( ).</li><li>Bural, G. 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ここで紹介する方法は、実行するのは簡単ですし、臨床的に重要な動脈床におけるアテローム性動脈硬化プラーク活動と血管の炎症に関する有用な情報を得ることができます。重点を保証するものではこの分析的なアプローチのいくつかの重要な機能があります：1）私達は、16検出器の行を持つ高品質のPET / CTスキャナを使用し、飛行能力の時間で、2）我々は、臨床情報を知らさ2経験豊かな...

<table border="1"><tbody><tr><td> 機器の名前 </td><td> 会社 </td></tr><tr><td>ジェミニTF PET / CTスキャナ</td><td>フィリップスヘルスケア</td></tr><tr><td>拡張されたブリリアンス·ワークステーション</td><td>フィリップスヘルスケア</td></tr></tbody></table>

quantification of atherosclerotic plaque activity and vascular inflammation using [18-f] fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct)

このような冠動脈カルシウム（CAC）1と頸動脈内膜中膜厚（C-IMT）2などのアテローム性動脈硬化症の従来の非侵襲的画像診断法は、疾患の負担に関する情報を提供します。しかし、CAC 3-5、およびC-IMT 2,6の複数の検証研究にもかかわらず、これらのモダリティは、正確にプラーク特性の7,8を評価していないと、プラークの組成および炎症状態は、その安定性、したがって、リスクを判断するの臨床的イベントは9月13日 。 [18 F]-2-フルオロ-2 -デオキシ-D-グルコース陽電子放射断層撮影（PET）/コンピュータ断層撮影（CT）を使用して（FDG）イメージングが広範囲に疡代謝14,15で検討されている。ヒトでの動物モデルおよび免疫組織化学を用いた研究はFDG-PET/CTはマクロファージ活性16、血管壁の細胞の炎症の重要なソースを検出するための絶妙に敏感であることを示します。モー最近再び、我々は17,18などはFDG-PET/CTは、大規模および中規模の動脈9,16,19,20におけるアテローム斑の活動の炎症活性の高精度、新たな測定を可能にすることが示されている。 FDG-PET/CTの研究では、他のイメージングモダリティに比べて多くの利点があります。マルチモーダルアテローム性動脈硬化プラークの定量化を可能にする2）プラーク容積の定量化と代謝活性、3）動的な、リアルタイムin vivoイメージング 1）高コントラスト分解能を。 4）最小限のオペレータ依存。最後に、FDG-PET/CTで検出された血管の炎症は、伝統的なリスク要因21,22の独立した心血管（CV）イベントを予測することが示されており、また非常にアテローム性動脈硬化症23の全体的な負担に関連付けられています。 FDG-PET/CTによるプラークの活動は、短期（12週）スタチン療法24と同様に長期的な治療ライフスタイルの変化などの既知の有益なCVの介入（16ヶ月）25によって変調される。 </P&gt; アテローム性動脈硬化プラークにおけるFDG集積の定量化のための現在の方法論は、割って計算され、バックグラウンド比（TBR）にターゲットを計算するために興味のあると静脈血プールの動脈の標準化取り込み値（SUV）の測定を含む静脈血プールSUVによって動脈のSUV。このメソッドは、時間の経過とともに安定した、再現可能な表現型を表すことが示さ血管の炎症の検出のための高感度を有しており、また、高間、イントラリーダーの信頼性26を有しています。ここでは、患者検体の調製、画像取得、およびアテローム性動脈硬化プラーク活動の定量化とSUV、TBR、代謝体積製品（MVP）と呼ばれるグローバルパラメータを使用して、血管の炎症のために私たちの方法論を提示します。我々はいくつかの先行出版物に示されているように、これらのアプローチは、一貫性のあるファッションに関心の様々な研究サンプルで血管の炎症を評価するために適用されるかもしれません。9,20,27,28は、&lt;/ SUP&gt;

Watch this Scientific Journal Video about Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography F

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

非侵襲的に動脈硬化を識別し、ここではFDG-PET/CTは、アテローム性動脈硬化プラーク活動と血管の炎症を検出し、定量化するために使用する方法を実証する大きな必要性がある。

アテローム性動脈硬化プラーク活動と血管の炎症の定量化を用いて[18 F]フルオロ陽電子放射断層撮影/コンピュータ断層撮影（FDG-PET/CT）

Conventional non-invasive imaging modalities of atherosclerosis such as coronary artery calcium (CAC)1 and carotid intimal medial thickness (C-IMT)2 ...

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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Basic Surgical Techniques in the G&ouml;ttingen Minipig: Intubation, Bladder Catheterization, Femoral Vessel Catheterization, and Transcardial Perfusion

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Cardiovascular disease is the leading cause of morbidity and mortality in the world.  Atherosclerotic plaques, consisting of lipid-laden macrophages and ...

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In endothermic animals, brown adipose tissue (BAT) is activated to produce heat for defending body temperature in response to cold. BAT&#39;s ability to ...

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